Levels of Plasma 8-Hydroxy-2'-Deoxyguanosine—A Marker of Oxidative DNA Damage—Are Not Associated with Primary Angle-closure Glaucoma

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i1631009 ◽

2021 ◽

pp. 132-138

Author(s):

Altaf A. Kondkar

Keyword(s):

Dna Damage ◽

Oxidative Dna Damage ◽

Statistical Significance ◽

Characteristic Curve ◽

Angle Closure Glaucoma ◽

University Hospital ◽

Angle Closure ◽

Clinical Markers ◽

Primary Angle Closure ◽

Primary Angle Closure Glaucoma

Aim: The study aimed to estimate plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels, a marker of oxidative deoxyribonucleic acid (DNA) damage, and evaluate their potential association with primary angle-closure glaucoma (PACG) and related clinical markers. Study Design: This is retrospective case-control study. Place and Duration: The study was performed on samples recruited from King Abdulaziz University Hospital, Riyadh, Saudi Arabia between August 2018 through September 2019 in the participants of Saudi origin. Methodology: Plasma 8-OHdG levels were measured in duplicates using automated ELISA analyzer in 43 PACG patients and 45 non-glaucomatous controls. Results: The mean levels of 8-OHdG were 13.59 ng/mL [±4.50] in PACG patients compared to 16.95 ng/mL [±10.66] in controls. The differences did not achieve statistical significance (P = 0.06). Similarly, no significant differences (P = 0.42) were observed in the median levels of 8-OHdG between PACG and controls. Furthermore, except for sex, where males exhibited a significant negative correlation (R = -0.35, P = 0.02), there was no significant correlation between 8-OHdG levels and age (P = 0.85), intraocular pressure (P = 0.58), cup/disc ratio (P = 0.39) and number of antiglaucoma medications (P = 0.41) in the PACG group. Regression analysis showed no significant influence of age, sex, and 8-OHdG levels on PACG outcome. Besides, the area under the receiver operating characteristic curve was 0.55 and non-significant (P = 0.42). Conclusion: There is no association between plasma levels of 8-OHdG and PACG or its specific clinical markers. Further studies in a much larger cohort are needed to validate these findings.

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Associations Between the Choroidal Vascularity Index and Malignant Glaucoma After Trabeculectomy for Primary Angle Closure Glaucoma

Frontiers in Medicine ◽

10.3389/fmed.2021.747720 ◽

2021 ◽

Vol 8 ◽

Author(s):

Chengguo Zuo ◽

Dingqiao Wang ◽

Xinxing Guo ◽

Hui Xiao ◽

Shaoyang Zheng ◽

...

Keyword(s):

Characteristic Curve ◽

Angle Closure Glaucoma ◽

Angle Closure ◽

Primary Angle Closure ◽

Primary Angle Closure Glaucoma ◽

Malignant Glaucoma ◽

Choroidal Vasculature ◽

Control Study ◽

Fellow Eyes ◽

Sd Oct

Purpose: To compare the choroidal vasculature characteristics by using the choroidal vascularity index (CVI) in eyes with malignant glaucoma (MG), fellow eyes with non-MG, and eyes with uncomplicated primary angle-closure glaucoma (PACG) after trabeculectomy by spectral-domain optical coherence tomography (SD-OCT).Methods: This case–control study included 53 patients diagnosed with MG after trabeculectomy. Eyes with MG (n = 53) and the fellow eyes with non-MG (n = 50) were included. Eyes with PACG without MG after trabeculectomy (n = 60) were also enrolled as controls. The choroidal parameters, including CVI and the subfoveal choroidal thickness (SFCT), were measured by using SD-OCT images.Results: Eyes with MG and the fellow eyes showed a significantly lower CVI than eyes with PACG controls (p < 0.001). After adjusting for age, sex, axial length (AL), and intraocular pressure (IOP), eyes with the greater CVI [odds ratio (OR), 0.44] were significantly related to MG. The area under the receiver operating characteristic curve of the CVI was greater than that of the SFCT in the diagnosis of MG (0.911 vs. 0.840, p = 0.034).Conclusion: Eyes with MG showed a significantly lower macular CVI than eyes with PACG controls. A higher macular CVI was an associated factor of eyes with MG. The CVI serves as a more stable and sensitive indicator for MG than the SFCT in this group of patients with PACG.

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Serum complement component 3, complement component 4 and complement component 1q levels predict progressive visual field loss in older women with primary angle closure glaucoma

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2021-320541 ◽

2022 ◽

pp. bjophthalmol-2021-320541

Author(s):

Shengjie Li ◽

Yichao Qiu ◽

Jian Yu ◽

Mingxi Shao ◽

Yingzhu Li ◽

...

Keyword(s):

Visual Field ◽

Older Women ◽

Statistical Significance ◽

Serum Levels ◽

Complement Component ◽

Angle Closure Glaucoma ◽

Angle Closure ◽

Generalised Additive Model ◽

Primary Angle Closure ◽

Primary Angle Closure Glaucoma

AimTo evaluate the association between serum levels of complement component (C) 3, C4 and C1q and visual field (VF) loss in patients with primary angle closure glaucoma (PACG).MethodsIn this prospective cohort study, a total of 308 patients with PACG were included. The patients were followed up every 6 months (at least 2 years), with clinical examination and VF testing. Based on their sex and age, the subjects were stratified into male and female subgroups, and by age at <60 and ≥60 years per subgroup.ResultsOne hundred twenty-three (39.94%) patients showed glaucoma VF progression. The serum levels of C3, C4 and C1q were significantly lower (p<0.05) in the progression group compared with the non-progression group in the ≥60 years female subgroup. In female patients with age ≥60 years, (1) lower levels of baseline C3 (HR=0.98, p<0.001), C4 (HR=0.96, p=0.01) and C1q levels (HR=0.99, p=0.003) were associated with a greater risk of VF progression; (2) patients with lower C3 levels had significantly (p<0.05) higher rates of VF loss progression, similar to those with lower C4 and lower C1q levels; and (3) the generalised additive model revealed a negative correlation between baseline C3 (p<0.001), C4 (p<0.001) and C1q (p<0.001) levels with the risk of VF progression. No statistical significance was observed in the male (<60 and ≥60 years) and female (<60 years) subgroups.ConclusionDecreased C3, C4 and C1q levels at baseline were significantly associated with a greater risk of VF loss progression only in older women with PACG.

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