The effect of different doses of aerobic exercise training on endothelial function in postmenopausal women with elevated blood pressure: results from the DREW study

Regular exercise enhances endothelial function in older men, but not consistently in estrogen-deficient postmenopausal women. Estradiol treatment improves basal endothelial function and restores improvements in endothelial function (flow-mediated dilation, FMD) to aerobic exercise training in postmenopausal women; however, estradiol treatment is controversial. Resveratrol, an estrogen receptor ligand, enhances exercise training effects on cardiovascular function and nitric oxide (NO) release in animal models, but impairs exercise training effects in men. We conducted a randomized cross-over, double-blinded, placebo-controlled pilot study to determine whether acute (single dose) resveratrol (250-mg tablet) or estradiol (0.05 mg/day transdermal patch) treatment enhances FMD at rest and after a single bout of moderate-intensity aerobic exercise in healthy estrogen-deficient postmenopausal women ( n = 15, 58.1 ± 3.2 yr). FMD was measured before and after (30, 60, and 120 min) a 40-min bout of moderate-intensity treadmill exercise (60–75% peak heart rate) under the respective conditions (separated by 1-2 wk). FMD was higher ( P < 0.05) before exercise and at all post-exercise time points in the resveratrol and estradiol conditions compared to placebo. FMD was increased from baseline by 120 min postexercise in the estradiol condition ( P < 0.001), but not resveratrol or PL conditions. Consistent with our previous findings, estradiol also enhances endothelial function in response to acute endurance exercise. Although resveratrol improved basal FMD, there was no apparent enhancement of FMD to acute exercise and, therefore, may not act as an estradiol mimetic. NEW & NOTEWORTHY The benefits of endurance exercise training on endothelial function are diminished in estrogen-deficient postmenopausal women, but estradiol treatment appears to restore improvements in endothelial function in this group. We show that basal endothelial function is enhanced with both acute estradiol and resveratrol treatments in estrogen-deficient postmenopausal women, but endothelial function is only enhanced following acute endurance exercise with estradiol treatment.

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Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure. A randomized controlled trial

Journal of Family Planning and Reproductive Health Care ◽

10.1783/147118907782102066 ◽

2007 ◽

Vol 33 (4) ◽

pp. 258-258 ◽

Cited By ~ 2

Author(s):

Fiona Denison

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Randomized Controlled Trial ◽

Postmenopausal Women ◽

Cardiorespiratory Fitness ◽

Controlled Trial ◽

Elevated Blood Pressure ◽

Elevated Blood ◽

Randomized Controlled ◽

Different Doses

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Effects of Different Doses of Physical Activity on Cardiorespiratory Fitness Among Sedentary, Overweight or Obese Postmenopausal Women With Elevated Blood Pressure: A Randomized Controlled Trial

Yearbook of Sports Medicine ◽

10.1016/s0162-0908(08)79161-x ◽

2008 ◽

Vol 2008 ◽

pp. 182-183

Author(s):

R.J. Shephard

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Randomized Controlled Trial ◽

Postmenopausal Women ◽

Cardiorespiratory Fitness ◽

Controlled Trial ◽

Elevated Blood Pressure ◽

Elevated Blood ◽

Randomized Controlled ◽

Different Doses

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A Single Dose of Beetroot Juice Does Not Change Blood Pressure Response Mediated by Acute Aerobic Exercise in Hypertensive Postmenopausal Women

Nutrients ◽

10.3390/nu11061327 ◽

2019 ◽

Vol 11 (6) ◽

pp. 1327 ◽

Cited By ~ 5

Author(s):

Ana Luiza Amaral ◽

Igor M. Mariano ◽

Victor Hugo V. Carrijo ◽

Tállita Cristina F. de Souza ◽

Jaqueline P. Batista ◽

...

Keyword(s):

Blood Pressure ◽

Exercise Training ◽

Aerobic Exercise ◽

Postmenopausal Women ◽

Blood Pressure Response ◽

Aerobic Exercise Training ◽

Exercise Session ◽

Beetroot Juice ◽

Post Exercise ◽

Before And After

Objective: To verify if acute intake of beetroot juice potentiates post-exercise hypotension (PEH) in hypertensive postmenopausal women. Methods: Thirteen hypertensive postmenopausal women (58.1 ± 4.62 years and 27.4 ± 4.25 kg/m²) were recruited to participate in three experimental sessions, taking three different beverages: Beetroot juice (BJ), placebo nitrate-depleted BJ (PLA), and orange flavored non-caloric drink (OFD). The participants performed moderate aerobic exercise training on a treadmill, at 65–70% of heart rate reserve (HRR), for 40 min. After an overnight fast, the protocol started at 07h when the first resting blood pressure (BP) was measured. The beverage was ingested at 07h30 and BP was monitored until the exercise training started, at 09h30. After the end of the exercise session, BP was measured every 15 min over a 90-min period. Saliva samples were collected at rest, immediately before and after exercise, and 90 min after exercise for nitrite (NO2−) analysis. Results: There was an increase in salivary NO2− with BJ intake when compared to OFD and PLA. A slight increase in salivary NO2− was observed with PLA when compared to OFD (p < 0.05), however, PLA resulted in lower salivary NO2− when compared to BJ (p < 0.001). There were no changes in salivary NO2− with the OFD. Systolic and diastolic BP decreased (p < 0.001) on all post exercise time points after all interventions, with no difference between the three beverages. Conclusion: Acute BJ intake does not change PEH responses in hypertensive postmenopausal women, even though there is an increase in salivary NO2−.

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