scholarly journals Plasma Steroid and Luteinizing Hormone Levels during Prostaglandin F2  Administration in Luteal Phase of Menstrual Cycle

BMJ ◽  
1972 ◽  
Vol 4 (5836) ◽  
pp. 333-336 ◽  
Author(s):  
K. Hillier ◽  
A. Dutton ◽  
C. S. Corker ◽  
A. Singer ◽  
M. P. Embrey
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Luteal Phase ◽  
Hormone Levels

scholarly journals Menstrual Cycle and Surgical Treatment of Breast Cancer: Findings From the NCCTG N9431 Study

2009 ◽  
Vol 27 (22) ◽  
pp. 3620-3626 ◽  
Author(s):  
Clive S. Grant ◽  
James N. Ingle ◽  
Vera J. Suman ◽  
Daniel A. Dumesic ◽  
D. Lawrence Wickerham ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Cycle Phase ◽  
Adjuvant Radiation ◽  
Menstrual Phase ◽  
Menstrual Cycle Phase ◽  
Hormone Levels ◽  
Menstrual History

Purpose For nearly two decades, multiple retrospective reports, small prospective studies, and meta-analyses have arrived at conflicting results regarding the value of timing surgical intervention for breast cancer on the basis of menstrual cycle phase. We present the results of a multi–cooperative group, prospective, observational trial of menstrual cycle phase and outcome after breast cancer surgery, led by the North Central Cancer Treatment Group (NCCTG) in collaboration with the National Surgical Adjuvant Breast and Bowel Project (NSABP) and the International Breast Cancer Study Group (IBCSG). Patients and Methods Premenopausal women age 18 to 55 years, who were interviewed for menstrual history and who were surgically treated for stages I to II breast cancer, had serum drawn within 1 day of surgery for estradiol, progesterone, and luteinizing hormone levels. Menstrual history and hormone levels were used to determine menstrual phase: luteal, follicular, and other. Disease-free survival (DFS) and overall survival (OS) rates were determined by Kaplan-Meier method and were compared by using the log-rank test and Cox proportional hazard modeling. Results Of 1,118 women initially enrolled, 834 women comprised the study cohort: 230 (28%) in luteal phase; 363 (44%) in follicular phase; and 241 grouped as other. During a median follow-up of 6.6 years, and in analysis that accounted for nodal disease, estrogen receptor status, adjuvant radiation therapy or chemotherapy, neither DFS nor OS differed with respect to menstrual phase. The 5-year DFS rates were 82.7%, 82.1%, and 79.2% for follicular, luteal, or other phases, respectively. Corresponding OS survival rates were 91.9%, 92.2%, and 91.8%, respectively. Conclusion When menstrual cycle phases were strictly defined, neither DFS nor OS differed between women who underwent surgery during the follicular phase versus the luteal phase. Nearly 30% of the patients did not meet criteria for either follicular- or luteal-phase categories.

The differential susceptibility of gonococcal opacity variants to sex hormones

1982 ◽  
Vol 28 (3) ◽  
pp. 301-306 ◽  
Author(s):  
Irving E. Salit
Keyword(s):  
Menstrual Cycle ◽  
Neisseria Gonorrhoeae ◽  
Growth Inhibition ◽  
Sex Hormones ◽  
Luteal Phase ◽  
Differential Susceptibility ◽  
Hormonal Influence ◽  
Hormone Levels

Neisseria gonorrhoeae exist in transparent (Tr) and opaque (Op) colony forms. Op forms are recovered from patients early in the menstrual cycle; Tr colonies predominate late in the cycle. The mechanism for this colonial variation was examined by determining the influence of gonodal hormones on growth inhibition of Op and Tr isogenic variants of gonococci. The estrogens, estrone and estradiol, enhanced growth whereas 19-nortestosterone, testosterone, and progesterone significantly inhibited gonococcal growth. Testosterone and progesterone inhibited growth of the Op variants to a greater degree than the Tr variants. Mixtures of Tr and Op colonies grown in the presence of progesterone became predominantly Tr, as occurs in the luteal phase of the menstrual cycle. This study supports the hypothesis of hormonal influence on colonial variation but employed artificial in vitro conditions and high hormone levels.

Normal Menstrual Cycle

2018 ◽  
Author(s):  
Rebecca Pierson ◽  
Kelly Pagidas
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Luteal Phase ◽  
Follicle Stimulating Hormone ◽  
Follicular Phase ◽  
Gonadotropin Releasing Hormone ◽  
Hormonal Control ◽  
Releasing Hormone ◽  
Normal Menstrual Cycle ◽  
Stimulating Hormone

A normal menstrual cycle is the end result of a sequence of purposeful and coordinated events that occur from intact hypothalamic-pituitary-ovarian and uterine axes. The menstrual cycle is under hormonal control in the reproductively active female and is functionally divided into two phases: the proliferative or follicular phase and the secretory or luteal phase. This tight hormonal control is orchestrated by a series of negative and positive endocrine feedback loops that alter the frequency of the pulsatile secretion of gonadotropin-releasing hormone (GnRH), the pituitary response to GnRH, and the relative secretion of luteinizing hormone and follicle-stimulating hormone from the pituitary gonadotrope with subsequent direct effects on the ovary to produce a series of sex steroids and peptides that aid in the generation of a single mature oocyte and the preparation of a receptive endometrium for implantation to ensue. Any derailment along this programmed pathway can lead to an abnormal menstrual cycle with subsequent impact on the ability to conceive and maintain a pregnancy. This review contains 7 figures and 26 references Key words: follicle-stimulating hormone, follicular phase, gonadotropin-releasing hormone, luteal phase, luteinizing hormone, menstrual cycle, ovulation, progesterone, proliferative phase, secretory phase

CHANGES IN THE BINDING OF HUMAN CHORIONIC GONADOTROPHIN/LUTEINIZING HORMONE, FOLLICLE-STIMULATING HORMONE AND PROLACTIN TO HUMAN CORPORA LUTEA DURING THE MENSTRUAL CYCLE AND PREGNANCY

1980 ◽  
Vol 87 (3) ◽  
pp. 315-325 ◽  
Author(s):  
A. S. McNEILLY ◽  
J. KERIN ◽  
I. A. SWANSTON ◽  
T. A. BRAMLEY ◽  
D. T. BAIRD
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Luteal Phase ◽  
Follicle Stimulating Hormone ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Corpora Lutea ◽  
Maximum Serum ◽  
Human Menstrual Cycle ◽  
Stimulating Hormone

The changes in the binding of human chorionic gonadotrophin/luteinizing hormone (HCG/LH), follicle-stimulating hormone (FSH) and prolactin to 44 corpora lutea have been assessed during the luteal phase of the human menstrual cycle and early pregnancy. All corpora lutea bound HCG but out of 32 only ten bound FSH and only seven bound prolactin specifically. While binding of HCG increased to maximal levels in the mid-luteal phase, binding of FSH and prolactin was most often found in the early luteal phase. Maximum binding of HCG was associated with maximum serum levels of progesterone. Luteal regression was associated with a decrease in the binding of HCG but a causal relationship could not be established. Very low binding of HCG was found to corpora lutea of pregnancy. These results show that (1) the changes in binding of HCG during the luteal phase of the human menstrual cycle are similar to those in other species and (2) there are specific binding sites for prolactin and FSH in the human corpus luteum.

LUTEINIZING HORMONE LEVELS DURING THE MENSTRUAL CYCLE OF THE BABOON (PAPIO HAMADRYAS)

1979 ◽  
Vol 91 (1) ◽  
pp. 49-58 ◽  
Author(s):  
N. Goncharov ◽  
A. V. Antonichev ◽  
V. M. Gorluschkin ◽  
L. Chachundocova ◽  
D. M. Robertson ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Plasma Levels ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Papio Hamadryas ◽  
Biologically Active ◽  
Plasma Progesterone ◽  
Lh Surge

ABSTRACT The peripheral plasma levels of luteinizing hormone (LH) as measured by an in vitro bioassay method were determined in daily plasma samples collected throughout one menstrual cycle in 8 normally menstruating baboons (Papio hamadryas). In addition LH was measured in plasma at three hourly intervals throughout the day in the follicular, peri-ovulatory and luteal phases of the cycle in 7, 3 and 6 animals respectively. The plasma levels of progesterone and oestradiol were also determined in the same samples throughout the menstrual cycle and during the period of the midcycle LH surge. The circulating LH profile measured throughout the cycle was characterized by a sharp mid-cycle surge (completed within one day) which was followed by a series of LH surges of varying intensity during the luteal phase of the cycle. The initial surge was considered to be pre-ovulatory as indicated by its relationship to the peak of plasma oestradiol and to the first significant increase in the levels of plasma progesterone above values found earlier in the follicular phase. A circadian rhythm of LH was observed during the luteal phase of the cycle; a 3 fold rise in LH was noted during the hours 15.00 to 24.00. No differences were observed throughout the day in the follicular phase of the cycle. The LH profile in three animals studied during the mid-cycle LH surge showed pronounced circadian changes with a major peak at 24.00 h. Plasma progesterone levels during this period rose sharply to values normally found in the mid-luteal phase of the cycle. A comparison of plasma levels of biologically active LH during the menstrual cycle of the baboon with those found in normally menstruating women reveals that in the baboon the LH peak is of much shorter duration and the levels in the follicular and peri-menstrual phases are significantly lower than in the human.

The effect of smoking on serum progesterone, estradiol, and luteinizing hormone levels over a menstrual cycle in normal women

Steroids ◽  
1990 ◽  
Vol 55 (11) ◽  
pp. 507-511 ◽  
Author(s):  
Barnett Zumoff ◽  
Lorraine Miller ◽  
Charles D. Levit ◽  
Ellen H. Miller ◽  
Ursula Heinz ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Serum Progesterone ◽  
Hormone Levels ◽  
Normal Women

Normal Menstrual Cycle

2018 ◽  
Author(s):  
Rebecca Pierson ◽  
Kelly Pagidas
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Luteal Phase ◽  
Follicle Stimulating Hormone ◽  
Follicular Phase ◽  
Gonadotropin Releasing Hormone ◽  
Hormonal Control ◽  
Releasing Hormone ◽  
Normal Menstrual Cycle ◽  
Stimulating Hormone

A normal menstrual cycle is the end result of a sequence of purposeful and coordinated events that occur from intact hypothalamic-pituitary-ovarian and uterine axes. The menstrual cycle is under hormonal control in the reproductively active female and is functionally divided into two phases: the proliferative or follicular phase and the secretory or luteal phase. This tight hormonal control is orchestrated by a series of negative and positive endocrine feedback loops that alter the frequency of the pulsatile secretion of gonadotropin-releasing hormone (GnRH), the pituitary response to GnRH, and the relative secretion of luteinizing hormone and follicle-stimulating hormone from the pituitary gonadotrope with subsequent direct effects on the ovary to produce a series of sex steroids and peptides that aid in the generation of a single mature oocyte and the preparation of a receptive endometrium for implantation to ensue. Any derailment along this programmed pathway can lead to an abnormal menstrual cycle with subsequent impact on the ability to conceive and maintain a pregnancy. This review contains 7 figures and 26 references Key words: follicle-stimulating hormone, follicular phase, gonadotropin-releasing hormone, luteal phase, luteinizing hormone, menstrual cycle, ovulation, progesterone, proliferative phase, secretory phase

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