Childhood onset inflammatory bowel disease and risk of cancer: a Swedish nationwide cohort study 1964-2014

Abstract Background The association between inflammatory bowel disease and malignancy is still controversial despite many observational studies. The Faroese population exhibits the highest occurrence of inflammatory bowel disease (IBD) in the world. The aim of this study was to investigate the risk of cancer in Faroese IBD patients within the nationwide Faroese IBD cohort. Methods This was a nationwide cohort study of all IBD patients diagnosed in the Faroe Islands from 1960 to 2014. Clinical demographics and cancer diagnosis were retrieved from patient files and from the Faroese cancer registry. Patients were followed until the event of cancer, death or emigration. Patients diagnosed with cancer prior to the IBD diagnosis were excluded. Observed numbers of cancer were compared with expected numbers based on ASR(N) (Nordic age- and sex-specific incidence rates) from Nordcan, by multiplying ASR(N) with person-years and follow-up in the study cohort and presented as standardised incidence ratios (SIRs) with 95 % intervals (CIs). Results The cohort consisted of 664 incidence IBD patients. After excluding 12 patients with cancer prior to IBD diagnosis, 652 patients with a total follow-up length of 11 476 person-years were included (414 UC with 7.494 patient-years, 128 IBDU with 2.038 patient-years and 110 CD with 1.944 patient-years). A total of 56 patients developed cancer during the follow-up period compared with 39.2 expected cases in the background population. We observed no gender difference. In UC, 33 observed compared with 25.7 expected patients developed cancer (SIR 1.28; 95% CI, 0.88–1.80). In IBDU, 13 observed compared with 6.9 expected patients developed cancer (SIR 1.88; 95% CI 1.00–0.22). In CD, 10 cases were observed compared with 6.6 expected (SIR 1.51; 95% CI 0.73–2.79). The most common types of cancers observed are shown in Table 1. Conclusion In this nationwide cohort study, we found no overall risk of cancer in IBD patients in the geographic isolated Faroe Island. However, skin cancer occurred more than expected in IBDU patients. This finding needs to be investigated further including the influence of treatment on cancer risk.

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Faculty Opinions recommendation of The association between water supply and inflammatory bowel disease based on a 1990-1993 cohort study in southeastern Norway.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1158308.618449 ◽

2009 ◽

Author(s):

Henk Jan Verkade

Keyword(s):

Inflammatory Bowel Disease ◽

Cohort Study ◽

Water Supply ◽

Bowel Disease ◽

Inflammatory Bowel

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Increased risk of chronic fatigue syndrome in patients with inflammatory bowel disease: a population-based retrospective cohort study

Journal of Translational Medicine ◽

10.1186/s12967-019-1797-3 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 3

Author(s):

Shin-Yi Tsai ◽

Hsuan-Ju Chen ◽

Chon-Fu Lio ◽

Chien-Feng Kuo ◽

An-Chun Kao ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Cohort Study ◽

Chronic Fatigue Syndrome ◽

Bowel Disease ◽

Retrospective Cohort ◽

Chronic Fatigue ◽

Population Based ◽

Fatigue Syndrome ◽

Increased Risk ◽

Inflammatory Bowel

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The incidence and prevalence of inflammatory bowel disease in UK primary care: a retrospective cohort study of the IQVIA Medical Research Database

BMC Gastroenterology ◽

10.1186/s12876-021-01716-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Karoline Freeman ◽

Ronan Ryan ◽

Nicholas Parsons ◽

Sian Taylor-Phillips ◽

Brian H. Willis ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

General Practice ◽

Cohort Study ◽

Medical Research ◽

Bowel Disease ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Research Database ◽

Care Providers ◽

Inflammatory Bowel

Abstract Background Our knowledge of the incidence and prevalence of inflammatory bowel disease (IBD) is uncertain. Recent studies reported an increase in prevalence. However, they excluded a high proportion of ambiguous cases from general practice. Estimates are needed to inform health care providers who plan the provision of services for IBD patients. We aimed to estimate the IBD incidence and prevalence in UK general practice. Methods We undertook a retrospective cohort study of routine electronic health records from the IQVIA Medical Research Database covering 14 million patients. Adult patients from 2006 to 2016 were included. IBD was defined as an IBD related Read code or record of IBD specific medication. Annual incidence and 12-month period prevalence were calculated. Results The prevalence of IBD increased between 2006 and 2016 from 106.2 (95% CI 105.2–107.3) to 142.1 (95% CI 140.7–143.5) IBD cases per 10,000 patients which is a 33.8% increase. Incidence varied across the years. The incidence across the full study period was 69.5 (95% CI 68.6–70.4) per 100,000 person years. Conclusions In this large study we found higher estimates of IBD incidence and prevalence than previously reported. Estimates are highly dependent on definitions of disease and previously may have been underestimated.

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