scholarly journals Coronary stenosis as a modifier of the effect of cold spells on the risk of sudden cardiac death: a case-crossover study in Finland

BMJ Open ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. e020865
Author(s):  
Niilo R I Ryti ◽  
M Juhani Junttila ◽  
Harri Antikainen ◽  
Marja-Leena Kortelainen ◽  
Heikki V Huikuri ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Coronary Stenosis ◽  
Conditional Logistic Regression ◽  
Temporal Trends ◽  
Cold Weather ◽  
Weather Data ◽  
Channel Blockers ◽  
Total Occlusion ◽  
Case Crossover

ObjectiveTo test the a priori hypothesis that the association between cold spells and ischaemic sudden cardiac death (SCD) is modified by the severity of coronary stenosis.MethodsThe home coordinates of 2572 autopsy-verified cases of ischaemic SCD aged ≥35 in the Province of Oulu, Finland, were linked to 51 years of weather data. Cold spell was statistically defined for each home address as unusually cold weather pertinent to the location and time of year. We estimated the occurrence of cold spells during the hazard period (7 days preceding death) and reference periods (the same calendar days over 51 years) in a case-crossover setting applying conditional logistic regression, controlling for temporal trends and stratifying by severity of coronary stenosis.ResultsThe association between cold spells and ischaemic SCD was stronger among patients with 75%–95% stenosis (OR 2.03; 95% CI 1.31 to 3.17), and weaker to non-existent among patients with <75% stenosis (OR 0.97; 95% CI 0.37 to 2.55) or coronary total occlusion (100% stenosis) (OR 1.01; 95% CI 0.52 to 1.96). Lack of calcium-channel blockers and statin therapy seemed to accentuate the role of stenosis during cold spells.ConclusionsWe provide evidence that the association between cold spells and ischaemic SCD is modified by the severity of coronary stenosis. The findings suggest that disturbances in coronary circulation play part in the pathogenesis of SCD during cold weather.

scholarly journals Risk of sudden cardiac death in relation to season-specific cold spells: a case–crossover study in Finland

BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e017398 ◽  
Author(s):  
Niilo R I Ryti ◽  
Elina M S Mäkikyrö ◽  
Harri Antikainen ◽  
Eeva Hookana ◽  
M Juhani Junttila ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Crossover Study ◽  
Cardiac Death ◽  
Weather Forecasting ◽  
Conditional Logistic Regression ◽  
A Priori ◽  
Temporal Trends ◽  
Cold Spell ◽  
Case Crossover ◽  
Medicolegal Autopsy

ObjectiveTo testa priorihypothesis of an association between season-specific cold spells and sudden cardiac death (SCD).MethodsWe conducted a case–crossover study of 3614 autopsy-verified cases of SCD in the Province of Oulu, Finland (1998–2011). Cold spell was statistically defined by applying an individual frequency distribution of daily temperatures at the home address during the hazard period (7 days preceding death) and 50 reference periods (same calendar days of other years) for each case using the home coordinates. Conditional logistic regression was applied to estimate ORs for the association between the occurrence of cold spells and the risk of SCD after controlling for temporal trends.ResultsThe risk of SCD was associated with a preceding cold spell (OR 1.33; 95% CI 1.00, 1.78). A greater number of cold days preceding death increased the risk of SCD approximately 19% per day (OR 1.19; 95% CI 1.07 to 1.32). The association was strongest during autumn (OR 2.51; 95% CI 1.27 to 4.96) and winter (OR 1.70; 95% CI 1.13 to 2.55) and lowest during summer (OR 0.42; 95% CI 0.15 to 1.18) and spring (OR 0.89; 95% CI 0.45 to 1.79). The association was stronger for ischaemic (OR 1.55; 95% CI 1.12 to 2.13) than for non-ischaemic SCD (OR 0.68; 95% CI 0.32 to 1.45) verified by medicolegal autopsy.ConclusionsOur results indicate that there is an association between cold spells and SCD, that this association is strongest during autumn, when the weather event is prolonged, and with cases suffering ischaemic SCD. These findings are subsumed with potential prevention via weather forecasting, medical advice and protective behaviour.

Age effect of antipsychotic medications on the risk of sudden cardiac death in patients with schizophrenia: A nationwide case–crossover study

2020 ◽  
Vol 74 (11) ◽  
pp. 594-601
Author(s):  
Pao‐Huan Chen ◽  
Shang‐Ying Tsai ◽  
Chun‐Hung Pan ◽  
Chi‐Kang Chang ◽  
Sheng‐Shiang Su ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Crossover Study ◽  
Cardiac Death ◽  
Age Effect ◽  
Antipsychotic Medications ◽  
Case Crossover

Temporal Trends in Sudden Cardiac Death From 1997 to 2010: A Data Linkage Study

2017 ◽  
Vol 26 (8) ◽  
pp. 808-816 ◽  
Author(s):  
Jia-Li Feng ◽  
Lee Nedkoff ◽  
Matthew Knuiman ◽  
Christopher Semsarian ◽  
Jodie Ingles ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Data Linkage ◽  
Temporal Trends ◽  
Linkage Study

scholarly journals Temporal Trends in Coronary Heart Disease Mortality and Sudden Cardiac Death From 1950 to 1999

Circulation ◽  
2004 ◽  
Vol 110 (5) ◽  
pp. 522-527 ◽  
Author(s):  
Caroline S. Fox ◽  
Jane C. Evans ◽  
Martin G. Larson ◽  
William B. Kannel ◽  
Daniel Levy
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Temporal Trends ◽  
Coronary Heart Disease Mortality ◽  
Disease Mortality

Aborted Sudden Cardiac Death Due to Radiofrequency Ablation Within the Coronary Sinus and Subsequent Total Occlusion of the Circumflex Artery

2013 ◽  
Vol 24 (8) ◽  
pp. 929-932 ◽  
Author(s):  
HISAKI MAKIMOTO ◽  
QINGYONG ZHANG ◽  
ROLAND RICHARD TILZ ◽  
ERIK WISSNER ◽  
ALESSANDRO CUNEO ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Sudden Cardiac Death ◽  
Coronary Sinus ◽  
Cardiac Death ◽  
Circumflex Artery ◽  
Total Occlusion

scholarly journals Cold weather and risk of sudden cardiac death in schizophrenia: finding a new Achilles' heel?

2008 ◽  
Vol 30 (2) ◽  
pp. 169-170 ◽  
Author(s):  
Fulvio A Scorza ◽  
Roberta M Cysneiros ◽  
Esper A Cavalheiro ◽  
Ricardo M Arida ◽  
Wagner F Gattaz
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Cold Weather

Abstract 15959: N-6 Polyunsaturated Fatty Acids in RBC Membranes and Estimated Desaturase Activities and Risk of Sudden Cardiac Death

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Stephanie E Chiuve ◽  
Nancy R Cook ◽  
M V Moorthy ◽  
J M Gaziano ◽  
Hannia Campos ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Sudden Cardiac Death ◽  
Polyunsaturated Fatty Acids ◽  
Cardiac Death ◽  
Lower Risk ◽  
Cell Membranes ◽  
Conditional Logistic Regression ◽  
Experimental Studies ◽  
Control Analysis

Introduction: Fatty acids in cell membranes modify the propensity for ventricular arrhythmias. In experimental studies, linoleic acid (LA;18:2n-6) has anti-arrhythmic effects, but its association with sudden cardiac death (SCD) risk has been inconsistent. Further, little is known about circulating levels of other n-6 polyunsaturated fatty acids(PUFA) and SCD risk. Methods: In a case-control analysis nested within 6 prospective cohort studies, we measured RBC levels of LA, γ-linolenic acid (GLA;18:3n-6), dihomo- γ-linoleic acid (DGLA;20:3n-6) and arachiodonic acid (AA; 20:4n-6) in 442 cases of SCD and 852 controls matched on age, sex, race, antecedent CVD, smoking status and fasting status using risk-set sampling. We estimated the activity of 2 key enzymes in n-6 PUFA metabolism, Δ-6desaurase (D6D), which converts LA to GLA, and Δ-5desaturase (D5D), which converts DGLA to AA, using their product to precursor ratios. The multivariable relative risks (RR) were estimated by conditional logistic regression adjusted for other CVD risk factors and n-3 PUFAs in each cohort separately and then combined with random effects meta-analyses. Results: DGLA was positivity linearly associated with risk of SCD while higher levels of AA were associated with lower risk of SCD. Additionally, higher D5D activity (DGLA/AA), representing greater metabolism of DGLA to AA, was inversely associated with risk (Table). Although LA demonstrated a U-shaped relation, with a nadir in SCD risk in quintile 3, the quadratic relation was not significant (p, quadratic trend = 0.95). Neither GLA nor D6D activity (GLA/LA) were associated with risk of SCD (Table). Conclusions: Higher RBC DGLA and lower RBC AA were associated with greater risk of SCD and greater estimated activity of the D5D was associated with lower risk. These n-6 PUFAs are not determined by n-6 PUFA intake and thus research on the regulation of DGLA and AA in cell membranes is warranted and may identify novel targets for SCD prevention.

scholarly journals B-PO04-156 TEMPORAL TRENDS IN THE INCIDENCE AND CHARACTERISTICS OF SUDDEN CARDIAC DEATH AMONG YOUNG IN NORTHERN FINLAND DURING 1998-2017

Heart Rhythm ◽  
2021 ◽  
Vol 18 (8) ◽  
pp. S342
Author(s):  
Lauri Holmström ◽  
Mira Anette Haukilahti ◽  
Juha Vähätalo ◽  
Lasse Pakanen, Janna Pauliina Kauppila ◽  
Henrik Appel ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Temporal Trends
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