scholarly journals P4631Chronic total occlusion represents an independent predictor for mortality in malignant arrhythmias and sudden cardiac death

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
M Behnes ◽  
I A Akin ◽  
E S B Brilakis ◽  
P K Kuche ◽  
T B Schupp ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Independent Predictor ◽  
Total Occlusion ◽  
Malignant Arrhythmias

scholarly journals Calcium Channel Autoantibodies Predicted Sudden Cardiac Death and All-Cause Mortality in Patients with Ischemic and Nonischemic Chronic Heart Failure

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Haiyun Yu ◽  
Juanhui Pei ◽  
Xiaoyan Liu ◽  
Jingzhou Chen ◽  
Xian Li ◽  
...  
Keyword(s):  
Heart Failure ◽  
Multivariate Analysis ◽  
Sudden Cardiac Death ◽  
Chronic Heart Failure ◽  
Cardiac Death ◽  
Independent Predictor ◽  
All Cause Mortality ◽  
Patient Prognosis ◽  
The Relationship

The purpose of this study was to evaluate whether CC-AAbs levels could predict prognosis in CHF patients. A total of 2096 patients with CHF (841 DCM patients and 1255 ICM patients) and 834 control subjects were recruited. CC-AAbs were detected and the relationship between CC-AAbs and patient prognosis was analyzed. During a median follow-up time of 52 months, there were 578 deaths. Of these, sudden cardiac death (SCD) occurred in 102 cases of DCM and 121 cases of ICM. The presence of CC-AAbs in patients was significantly higher than that of controls (bothP<0.001). Multivariate analysis revealed that positive CC-AAbs could predict SCD (HR 3.191, 95% CI 1.598–6.369 for DCM; HR 2.805, 95% CI 1.488–5.288 for ICM) and all-cause mortality (HR 1.733, 95% CI 1.042–2.883 for DCM; HR 2.219, 95% CI 1.461–3.371 for ICM) in CHF patients. A significant association between CC-AAbs and non-SCD (NSCD) was found in ICM patients (HR = 1.887, 95% CI 1.081–3.293). Our results demonstrated that the presence of CC-AAbs was higher in CHF patients versus controls and corresponds to a higher incidence of all-cause death and SCD. Positive CC-AAbs may serve as an independent predictor for SCD and all-cause death in these patients.

scholarly journals Coronary stenosis as a modifier of the effect of cold spells on the risk of sudden cardiac death: a case-crossover study in Finland

BMJ Open ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. e020865
Author(s):  
Niilo R I Ryti ◽  
M Juhani Junttila ◽  
Harri Antikainen ◽  
Marja-Leena Kortelainen ◽  
Heikki V Huikuri ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Coronary Stenosis ◽  
Conditional Logistic Regression ◽  
Temporal Trends ◽  
Cold Weather ◽  
Weather Data ◽  
Channel Blockers ◽  
Total Occlusion ◽  
Case Crossover

ObjectiveTo test the a priori hypothesis that the association between cold spells and ischaemic sudden cardiac death (SCD) is modified by the severity of coronary stenosis.MethodsThe home coordinates of 2572 autopsy-verified cases of ischaemic SCD aged ≥35 in the Province of Oulu, Finland, were linked to 51 years of weather data. Cold spell was statistically defined for each home address as unusually cold weather pertinent to the location and time of year. We estimated the occurrence of cold spells during the hazard period (7 days preceding death) and reference periods (the same calendar days over 51 years) in a case-crossover setting applying conditional logistic regression, controlling for temporal trends and stratifying by severity of coronary stenosis.ResultsThe association between cold spells and ischaemic SCD was stronger among patients with 75%–95% stenosis (OR 2.03; 95% CI 1.31 to 3.17), and weaker to non-existent among patients with <75% stenosis (OR 0.97; 95% CI 0.37 to 2.55) or coronary total occlusion (100% stenosis) (OR 1.01; 95% CI 0.52 to 1.96). Lack of calcium-channel blockers and statin therapy seemed to accentuate the role of stenosis during cold spells.ConclusionsWe provide evidence that the association between cold spells and ischaemic SCD is modified by the severity of coronary stenosis. The findings suggest that disturbances in coronary circulation play part in the pathogenesis of SCD during cold weather.

Commotio cordis: A review

2017 ◽  
Vol 57 (3) ◽  
pp. 146-151 ◽  
Author(s):  
Ritesh G Menezes ◽  
Huda Fatima ◽  
Syed Ather Hussain ◽  
Saba Ahmed ◽  
Pankaj Kumar Singh ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Survival Rates ◽  
Post Mortem ◽  
High Velocity Impact ◽  
Young Athletes ◽  
Common Cause ◽  
Velocity Impact ◽  
Commotio Cordis ◽  
Malignant Arrhythmias

Commotio cordis is an increasingly reported fatal mechano-electric syndrome and is the second most common cause of sudden cardiac death in young athletes. It is most commonly associated with a sports-related injury, wherein, there is a high-velocity impact between a projectile and the precordium. By virtue of this impact, malignant arrhythmias consequently develop leading to the individual’s immediate demise, accompanied by a relatively normal post-mortem analysis. The importance of an autopsy remains paramount to exclude other causes of sudden death. With increasing awareness and reporting, survival rates are beginning to improve; however, prevention of the development of this condition remains the best approach for survival.

Aborted Sudden Cardiac Death Due to Radiofrequency Ablation Within the Coronary Sinus and Subsequent Total Occlusion of the Circumflex Artery

2013 ◽  
Vol 24 (8) ◽  
pp. 929-932 ◽  
Author(s):  
HISAKI MAKIMOTO ◽  
QINGYONG ZHANG ◽  
ROLAND RICHARD TILZ ◽  
ERIK WISSNER ◽  
ALESSANDRO CUNEO ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Sudden Cardiac Death ◽  
Coronary Sinus ◽  
Cardiac Death ◽  
Circumflex Artery ◽  
Total Occlusion

Molecular and genetic background of sudden cardiac death

2012 ◽  
Vol 153 (50) ◽  
pp. 1967-1983
Author(s):  
József Simkó ◽  
Zoltán Szabó ◽  
Kitti Barta ◽  
Dóra Újvárosi ◽  
Péter Nánási ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Current Literature ◽  
Myocardial Ischaemia ◽  
Genetic Background ◽  
Cardiac Death ◽  
Entire Population ◽  
Intracellular Ca ◽  
Cardiac Autonomic Innervation ◽  
Malignant Arrhythmias

Despite recent findings on the functional, structural and genetic background of sudden cardiac death, the incidence is still relatively high in the entire population. A thorough knowledge on susceptibility, as well as pathophysiology behind the development of malignant arrhythmias will help us to identify individuals at risk and prevent sudden cardiac death. This article presents a review of the current literature on the role of altered intracellular Ca2+ handling, acute myocardial ischaemia, cardiac autonomic innervation, renin-angiotensin-aldosterone system, monogenic and complex heritability in the pathogenesis of sudden cardiac death. Orv. Hetil., 2012, 153, 1967–1983.

Sign in / Sign up

Export Citation Format

Share Document