scholarly journals Quality and outcomes in global cancer surgery: protocol for a multicentre, international, prospective cohort study (GlobalSurg 3)

BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e026646 ◽  
Author(s):  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Observational Data ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Cancer Surgery ◽  
Risk Of Death ◽  
Low Middle Income Countries ◽  
Increased Risk ◽  
Quality And Outcomes

IntroductionEmpirical, observational data relating to the diagnosis, management and outcome of three common worldwide cancers requiring surgery is lacking. However, it has been demonstrated that patients in low/middle-income countries undergoing surgery for cancer are at increased risk of death and major complications postoperatively. This study aims to determine quality and outcomes in breast, gastric and colorectal cancer surgery across worldwide hospital settings.Methods and analysisThis multicentre, international prospective cohort study will be undertaken by any hospital providing emergency or elective surgical services for breast, gastric or colorectal cancer. Centres will collect observational data on consecutive patients undergoing primary emergency or elective surgery for breast, gastric or colorectal cancer during a 6-month period. The primary outcome is the incidence of mortality and major complication rate at 30 days after cancer surgery. Infrastructure and care processes in the treatment of these cancers worldwide will also be characterised.Ethics and disseminationThis project will not affect clinical practice and has been classified as clinical audit following research ethics review. The protocol will be disseminated through the international GlobalSurg network.Trial registration numberNCT03471494; Pre-results.

scholarly journals Early Inflammatory Biomarkers as Predictive Factors for Freedom from Infection after Colorectal Cancer Surgery: A Prospective Cohort Study

2018 ◽  
Vol 19 (4) ◽  
pp. 446-450 ◽  
Author(s):  
André Goulart ◽  
Carla Ferreira ◽  
Alexandra Estrada ◽  
Fernanda Nogueira ◽  
Sandra Martins ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Predictive Factors ◽  
Prospective Cohort ◽  
Cancer Surgery ◽  
Inflammatory Biomarkers ◽  
Colorectal Cancer Surgery

scholarly journals 30-day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: a prospective cohort study

2020 ◽  
Author(s):  
Andrea Giacomelli ◽  
Anna Lisa Ridolfo ◽  
Laura Milazzo ◽  
Letizia Oreni ◽  
Dario Bernacchia ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Case Fatality ◽  
Time Dependent ◽  
Advanced Illness ◽  
Risk Of Death ◽  
Increased Risk ◽  
Probability Of Death ◽  
Dependent Probability

AbstractBackgroundItaly was the first European country hit by the COVID-19 pandemic and has the highest number of recorded COVID-19 deaths in Europe.MethodsThis prospective cohort study of the correlates of the risk of death in COVID-19 patients was conducted at the Infectious Diseases and Intensive Care units of Luigi Sacco Hospital, Milan, Italy. The clinical characteristics of all the COVID-19 patients hospitalised in the early days of the epidemic (21 February -19 March 2020) were recorded upon admission, and the time-dependent probability of death was evaluated using the Kaplan-Meier method (censored as of 20 April 2020). Cox proportional hazard models were used to assess the factors independently associated with the risk of death.ResultsForty-eight (20.6%) of the 233 patients followed up for a median of 40 days (interquartile range 33-47) died during the follow-up. Most were males (69.1%) and their median age was 61 years (IQR 50-72). The time-dependent probability of death was 19.7% (95% CI 14.6-24.9%) 30 days after hospital admission. Age (adjusted hazard ratio [aHR] 2.08, 95% CI 1.48-2.92 per ten years more) and obesity (aHR 3.04, 95% CI 1.42-6.49) were independently associated with an increased risk of death, which was also associated with critical disease (aHR 8.26, 95% CI 1.41-48.29), C-reactive protein levels (aHR 1.17, 95% CI 1.02-1.35 per 50 mg/L more) and creatinine kinase levels above 185 U/L (aHR 2.58, 95% CI 1.37-4.87) upon admission.ConclusionsCase-fatality rate of patients hospitalized with COVID-19 in the early days of the Italian epidemic was about 20%. Our study adds evidence to the notion that older age, obesity and more advanced illness are factors associated to an increased risk of death among patients hospitalized with COVID-19.

scholarly journals An increase in physical activity after colorectal cancer surgery is associated with improved recovery of physical functioning: a prospective cohort study

BMC Cancer ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Moniek van Zutphen ◽  
Renate M. Winkels ◽  
Fränzel J. B. van Duijnhoven ◽  
Suzanne A. van Harten-Gerritsen ◽  
Dieuwertje E. G. Kok ◽  
...  
Keyword(s):  
Physical Activity ◽  
Colorectal Cancer ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Physical Functioning ◽  
Prospective Cohort ◽  
Cancer Surgery ◽  
Colorectal Cancer Surgery

scholarly journals The Effect of Diabetes and Prediabetes on Anti-tuberculosis Treatment Outcomes: A Multicentric Prospective Cohort Study

2021 ◽  
Author(s):  
María B. Arriaga ◽  
Mariana Araújo-Pereira ◽  
Beatriz Barreto-Duarte ◽  
Betânia Nogueira ◽  
Maria Vitória C.N.S. Freire ◽  
...  
Keyword(s):  
Cohort Study ◽  
Treatment Outcomes ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Univariate Analysis ◽  
Tuberculosis Treatment ◽  
Observational Research ◽  
Glycemic Status ◽  
Risk Of Death ◽  
Increased Risk

ABSTRACTBackgroundIt is unclear whether diabetes or prediabetes drives adverse treatment outcomes and death in people with tuberculosis (PWTB).MethodsCulture-confirmed PWTB, enrolled in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort between 2015 and 2019 (n=756) were stratified based on glycemic status by baseline glycated hemoglobin levels. Unfavorable TB outcome was defined as treatment failure or modification, recurrence or death, whereas favorable outcome was cure or treatment completion. We validated the findings using data from PWTB reported to the Brazilian National System of Diseases Notification (SINAN) during 2015-2019 (n=20,989). Stepwise binary multivariable regression analysis models evaluated associations between glycemic status and unfavorable outcomes.ResultsIn both cohorts, in univariate analysis, unfavorable outcomes were more frequently associated with drug resistance and HIV infection. Diabetes was associated with unfavorable outcomes in the RePORT (aOR: 2.85, p=0.001) and in SINAN (aOR: 1.56, p=0.040) cohorts. Furthermore, diabetes was associated with higher risk of death in both, RePORT-Brazil (aOR:3.23, p=0.006) and in the SINAN (aOR:2.75, p= 0.047) cohorts.ConclusionDiabetes was associated with an increased risk of unfavorable outcomes and mortality in Brazilian PWTB. Interventions to improve tuberculosis treatment outcomes in persons with diabetes are needed.40-word summary of the article’s main pointIn a multicenter prospective cohort study from Brazil, diabetes was associated with an increased risk of unfavorable treatment outcomes, including mortality, in pulmonary tuberculosis patients. These observations were validated in the Brazilian National Disease Notification System during the same period.

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