Predicting postoperative fatigue in surgically treated lung cancer patients in Norway: a longitudinal 5-month follow-up study

ObjectivesDespite the negative influence of fatigue on quality of life in patients who undergo lung cancer surgery, little is known about the possible predictors of postoperative fatigue. The aim of this study was to examine demographic and clinical characteristics that might predict postoperative fatigue 5 months after lung cancer surgery.DesignA prospective longitudinal follow-up study comprising preoperative and postoperative questionnaires, including Lee Fatigue Scale, and sociodemographic and clinical data.SettingThree university hospitals in Norway (eg, Oslo University Hospital, St. Olav University Hospital and Haukeland University Hospital).ParticipantsIn total, 196 surgically treated patients who answered the questionnaires both preoperatively and at 5-month follow-up with valid fatigue scores.ResultsBivariate analyses showed that preoperative fatigue was associated with comorbidities and the symptoms of shortness of breath, cough, depression, anxiety, sleep disturbance and pain. Only cough was directly associated with preoperative fatigue in a regression model. Comorbidities and the symptoms of shortness of breath, cough, depression and sleep disturbance were associated with postoperative fatigue in the bivariate analyses, but only shortness of breath was associated with postoperative fatigue in the regression model. We did not find any significant correlations between fatigue and any treatment variable.ConclusionClinicians should pay special attention to lung symptoms and be aware that these may lead to long-term postoperative fatigue. Further research should examine whether interventions reducing lung symptoms, such as shortness of breath and coughing, may prevent development of fatigue in patients undergoing lung cancer surgery.

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Incidence and Risk Factors of Chronic Pulmonary Aspergillosis Development during Long-Term Follow-Up after Lung Cancer Surgery

Journal of Fungi ◽

10.3390/jof6040271 ◽

2020 ◽

Vol 6 (4) ◽

pp. 271

Author(s):

Sun Shin ◽

Bo-Guen Kim ◽

Jiyeon Kang ◽

Sang-Won Um ◽

Hojoong Kim ◽

...

Keyword(s):

Lung Cancer ◽

Cumulative Incidence ◽

Lung Cancer Surgery ◽

Cancer Surgery ◽

Pulmonary Aspergillosis ◽

Factors Associated ◽

Long Term Follow Up ◽

Chronic Pulmonary Aspergillosis

Lung resection surgery for non-small-cell lung cancer (NSCLC) is reportedly a risk factor for developing chronic pulmonary aspergillosis (CPA). However, limited data are available regarding the development of CPA during long-term follow-up after lung cancer surgery. This study aimed to investigate the cumulative incidence and clinical factors associated with CPA development after lung cancer surgery. We retrospectively analyzed 3423 patients with NSCLC who (1) underwent surgical resection and (2) did not have CPA at the time of surgery between January 2010 and December 2013. The diagnosis of CPA was based on clinical symptoms, serological or microbiological evidences, compatible radiological findings, and exclusion of alternative diagnoses. The cumulative incidence of CPA and overall survival (OS) were estimated using the Kaplan–Meier method, and a multivariable Cox proportional hazard analysis was performed to identify factors associated with CPA development. Patients were followed-up for a median of 5.83 years with a 72.3% 5-year OS rate. Fifty-six patients developed CPA at a median of 2.68 years after surgery, with cumulative incidences of 0.4%, 1.1%, 1.6%, and 3.5% at 1, 3, 5, and 10 years, respectively. Lower body mass index (BMI), smoking, underlying interstitial lung disease, thoracotomy, development of postoperative pulmonary complications 30 days after surgery, and treatment with both chemotherapy and radiotherapy were independently associated with CPA development. The cumulative incidence of CPA after surgery was 3.5% at 10 years and showed a steadily increasing trend during long-term follow-up. Therefore, increased awareness regarding CPA development is needed especially in patients with risk factors.

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Importance of follow-up inspection after pulmonary angioplastic procedures for lung cancer surgery

General Thoracic and Cardiovascular Surgery ◽

10.1007/s11748-009-0508-z ◽

2010 ◽

Vol 58 (1) ◽

pp. 1-2 ◽

Cited By ~ 2

Author(s):

Takeshi Nagayasu

Keyword(s):

Lung Cancer ◽

Lung Cancer Surgery ◽

Cancer Surgery

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Early and Late Outcome, Mortality and Major Morbidity After Lung Cancer Surgery for Primary Carcinoma

Albanian Journal of Trauma and Emergency Surgery ◽

10.32391/ajtes.v2i2.12 ◽

2018 ◽

Vol 2 (2) ◽

Author(s):

Fadil Gradica ◽

L. Lisha ◽

Dh. Argjiri ◽

A. Cani ◽

F. Kokici ◽

...

Keyword(s):

Lung Cancer ◽

Lung Cancer Surgery ◽

Cardiovascular Complications ◽

Cancer Surgery ◽

University Hospital ◽

Mortality And Morbidity ◽

Preoperative Ct ◽

Laboratory Examinations ◽

Surgical Modality ◽

Upper Abdomen

Background: Radical surgical resection of lung cancer with or without adjuvant treatment is still a prerequisitefor cure. Advances in operative and postoperative care led to a decline in complications and mortality rates during the last decades. In spite of different additional modes of treatment, survival is still poor.The aim of study: To examine the operative mortality and morbidity after lung cancer surgery and to identify factors associated with an adverse outcome.Material and methods: The study comprised 968 consecutive patients referred to University Hospital of Lung Disease, “Shefqet Ndroqi” Tirana, Albania, for lung carcinoma, during a 13-years period (January 2004-December 2017). All patients underwent routine laboratory examinations spirometry and preoperative CT- scan of the thorax and upper abdomen. PET-CT, EBUS–EUS, Mediastinotomy or Mediastinoscopy wasn’t performed as routine.Results: Of 968 patients, 690 (70.5%) were male and 278 (28.7%) female. Mean age 65.5±9.4 years (range 15 - 87 years). Lobectomy was the most used surgical modality in 566 (58.5%) patients, meanwhile pneumonectomy was performed in 112 (11.6%) of patients. Minor complications during surgery occurred in 45 (11.7%) ofpatients. Continuous air leakage was the most complication after surgery in 25.3%, followed by lung atelectasis in 21.3% and cardiovascular complications in 17%.Conclusion: our results show low mortality and morbidity after lung cancer surgery. However, patients with reduced lung capacity, older age and those undergoing pneumonectomy should be treated with great care.

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