Live birth after in vitro maturation versus standard in vitro fertilisation for women with polycystic ovary syndrome: protocol for a non-inferiority randomised clinical trial

IntroductionPolycystic ovary syndrome (PCOS) is the first common cause of anovulatory infertility. Currently, in vitro fertilisation (IVF) is recommended when conventional attempts have failed. In vitro maturation (IVM) of human oocytes is an emerging treatment option in infertile women with PCOS. It is a patient-friendly intervention, avoiding the risk of ovarian hyperstimulation syndrome, which is a serious complication of controlled ovarian stimulation in the standard IVF procedure. We plan a randomised controlled trial (RCT) to evaluate whether IVM is non-inferior to the standard IVF for live birth in women with PCOS.Methods and analysisThis is a single-centre, open-label, non-inferiority RCT performed in a large reproductive medicine centre in China. Infertile women with PCOS will be randomised to receive either IVM or standard IVF in a 1:1 treatment ratio after informed consent. IVF procedures used in our study are all standard treatments and other standard-assisted reproductive technologies will be similar between the two groups. The primary outcome is ongoing pregnancy leading to live birth within 6 months of the first oocyte retrieval cycle after randomisation. Pregnancy outcome, maternal safety and obstetric and perinatal complications will be secondary outcomes. The planned sample size is 350 (175 per group).Ethics and disseminationEthical permission was acquired from the Ethics Committee of Peking University Third Hospital. The results will be issued to publications through scientific journals and conference reports.Trial registration numberNCT03463772.

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Effects of Oral Contraceptives and Metformin on the Outcome of In Vitro Maturation in Infertile Women with Polycystic Ovary Syndrome

Journal of Women s Health ◽

10.1089/jwh.2009.1491 ◽

2010 ◽

Vol 19 (2) ◽

pp. 261-265 ◽

Cited By ~ 5

Author(s):

Jun-Zhao Zhao ◽

Jin-Ju Lin ◽

Hai-Yan Yang ◽

Wei Zhang ◽

Xue-Feng Huang ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Oral Contraceptives ◽

In Vitro Maturation ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Infertile Women

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Concomitant ovarian drilling and oocyte retrieval by laparoendoscopic single-site surgery led to live birth using in vitro maturation of oocyte and transfer of frozen-thawed blastocyst in woman with polycystic ovary syndrome

Journal of Obstetrics and Gynaecology Research ◽

10.1111/jog.12365 ◽

2014 ◽

Vol 40 (5) ◽

pp. 1431-1435 ◽

Cited By ~ 1

Author(s):

Tetsuya Hirata ◽

Akihisa Fujimoto ◽

Kaori Koga ◽

Osamu Wada-Hiraike ◽

Tomoyuki Fujii ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Live Birth ◽

In Vitro Maturation ◽

Polycystic Ovary ◽

Oocyte Retrieval ◽

Ovary Syndrome ◽

Ovarian Drilling ◽

Laparoendoscopic Single Site Surgery ◽

Single Site Surgery

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IVF efficiency in different phenotypes of polycystic ovary syndrome

Journal of obstetrics and women s diseases ◽

10.17816/jowd61933 ◽

2021 ◽

Vol 70 (4) ◽

pp. 81-90

Author(s):

Igor P. Nikolayenkov ◽

Olga E. Kazymova ◽

Dmitry S. Sudakov ◽

Yulia R. Dymarskaya

Keyword(s):

In Vitro Fertilization ◽

Polycystic Ovary Syndrome ◽

Metabolic Disorders ◽

Assisted Reproductive Technologies ◽

Polycystic Ovary ◽

Reproductive Technologies ◽

Ovary Syndrome ◽

Vitro Fertilization ◽

Hormonal Profile

Polycystic ovary syndrome occupies a leading place in the structure of endocrine infertility. This article presents the endocrine and metabolic features of the polycystic ovary syndrome phenotypes, as well as modern concepts of efficiency and complications of the use of assisted reproductive technologies, depending on the specific phenotype. The issues of polycystic ovary syndrome influence on selecting the method of assisted reproductive technologies, as well as possible complications that occur during in vitro fertilization and the features of the pregnancy course remain unresolved. The individualization of the approach seems to be promising when taking into account the differences in the hormonal profile and the features of metabolic disorders in each polycystic ovary syndrome phenotype. That may allow us to take one more step towards improving the effectiveness of in vitro fertilization and reducing the frequency of complications in patients with polycystic ovary syndrome.

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Cumulative live birth rates (CLBR) after in vitro maturation (IVM) of oocytes in patients with polycystic ovary syndrome (PCOS): does PCOS phenotype have an impact?

10.26226/morressier.5af300b3738ab10027aa99c1 ◽

2018 ◽

Author(s):

Tine Deckers ◽

Michel De Vos

Keyword(s):

Polycystic Ovary Syndrome ◽

Live Birth ◽

In Vitro Maturation ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Birth Rates ◽

Live Birth Rates ◽

Cumulative Live Birth

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Predictive factors for live birth after in vitro maturation of oocytes in women with polycystic ovary syndrome

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-017-4561-z ◽

2017 ◽

Vol 297 (1) ◽

pp. 199-204 ◽

Cited By ~ 9

Author(s):

Samer Tannus ◽

Safak Hatirnaz ◽

Justin Tan ◽

Baris Ata ◽

Seang-Lin Tan ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Live Birth ◽

Predictive Factors ◽

In Vitro Maturation ◽

Polycystic Ovary ◽

Ovary Syndrome

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Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome

Journal of Ovarian Research ◽

10.1186/s13048-018-0445-5 ◽

2018 ◽

Vol 11 (1) ◽

Cited By ~ 11

Author(s):

V. N. A. Ho ◽

T. D. Pham ◽

A. H. Le ◽

T. M. Ho ◽

L. N. Vuong

Keyword(s):

Polycystic Ovary Syndrome ◽

Live Birth ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

In Vitro Maturation ◽

Birth Rate ◽

Polycystic Ovary ◽

Live Birth Rate ◽

Ovary Syndrome

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Association between baseline LH/FSH and live-birth rate after fresh-embryo transfer in polycystic ovary syndrome women

Scientific Reports ◽

10.1038/s41598-021-99850-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Nian-jun Su ◽

Cui-yu Huang ◽

Jie Liu ◽

De-ying Kang ◽

Song-lu Wang ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Embryo Transfer ◽

Live Birth ◽

Birth Rate ◽

Polycystic Ovary ◽

Live Birth Rate ◽

In Vitro Fertilisation ◽

Fresh Embryo Transfer ◽

Ovary Syndrome

AbstractThis study aimed to retrospectively analyse the effect of the baseline luteinising hormone/follicle-stimulating hormone ratio (bLH/FSH) on the live-birth rate per fresh-embryo transfer cycle (LBR/ET) in infertile women with polycystic ovary syndrome (PCOS) who received a fresh-embryo transfer. A total of 424 patients with PCOS who underwent the first cycle of in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) fresh-embryo transfer at our hospital was enrolled. Univariate and multivariate logistic regression analyses, along with curve fitting and a threshold effect analysis, were performed. Baseline LH/FSH levels were a significant (P < 0.05) independent risk factor affecting live birth. In the first IVF/ICSI antagonist treatment cycles, LBR/ET after fresh-embryo transfer was relatively flat, until bLH/FSH was 1.0; thereafter, it started to decrease by 17% for every 0.1-unit bLH/FSH increase. Considering the decline in LBR/ET, it is recommended that PCOS women with bLH/FSH > 1.0 carefully consider fresh-embryo transfer during their first IVF/ICSI.

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