scholarly journals Characterising activity and diet compositions for dementia prevention: protocol for the ACTIVate prospective longitudinal cohort study

BMJ Open ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. e047888
Author(s):  
Ashleigh E Smith ◽  
Alexandra T Wade ◽  
Timothy Olds ◽  
Dorothea Dumuid ◽  
Michael J Breakspear ◽  
...  
Keyword(s):  
Cohort Study ◽  
Time Use ◽  
Brain Function ◽  
Event Related Potential ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Time Frequency ◽  
Dementia Prevention ◽  
Prospective Longitudinal ◽  
Prospective Longitudinal Cohort

IntroductionApproximately 40% of late-life dementia may be prevented by addressing modifiable risk factors, including physical activity and diet. Yet, it is currently unknown how multiple lifestyle factors interact to influence cognition. The ACTIVate Study aims to (1) explore associations between 24-hour time-use and diet compositions with changes in cognition and brain function; and (2) identify duration of time-use behaviours and the dietary compositions to optimise cognition and brain function.Methods and analysisThis 3-year prospective longitudinal cohort study will recruit 448 adults aged 60–70 years across Adelaide and Newcastle, Australia. Time-use data will be collected through wrist-worn activity monitors and the Multimedia Activity Recall for Children and Adults. Dietary intake will be assessed using the Australian Eating Survey food frequency questionnaire. The primary outcome will be cognitive function, assessed using the Addenbrooke’s Cognitive Examination-III. Secondary outcomes include structural and functional brain measures using MRI, cerebral arterial pulse measured with diffuse optical tomography, neuroplasticity using simultaneous transcranial magnetic stimulation and electroencephalography, and electrophysiological markers of cognitive control using event-related potential and time frequency analyses. Compositional data analysis, testing for interactions between time point and compositions, will assess longitudinal associations between dependent (cognition, brain function) and independent (time-use and diet compositions) variables.ConclusionsThe ACTIVate Study will be the first to examine associations between time-use and diet compositions, cognition and brain function. Our findings will inform new avenues for multidomain interventions that may more effectively account for the co-dependence between activity and diet behaviours for dementia prevention.Ethics and disseminationEthics approval has been obtained from the University of South Australia’s Human Research Ethics committee (202639). Findings will be disseminated through peer-reviewed manuscripts, conference presentations, targeted media releases and community engagement events.Trial registration numberAustralia New Zealand Clinical Trials Registry (ACTRN12619001659190).

scholarly journals Optimising activity and diet compositions for dementia prevention: Protocol for the ACTIVate prospective longitudinal cohort study

2021 ◽  
Author(s):  
Ashleigh Elizabeth Smith ◽  
Alexandra T Wade ◽  
Timothy S Olds ◽  
Dorothea Dumuid ◽  
Michael Breakspear ◽  
...  
Keyword(s):  
Cohort Study ◽  
Time Use ◽  
Brain Function ◽  
Event Related Potential ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Time Frequency ◽  
Dementia Prevention ◽  
Prospective Longitudinal ◽  
Prospective Longitudinal Cohort

Introduction Approximately 40% of late-life dementia may be prevented by addressing modifiable risk factors, including physical activity and diet. Yet, it is currently unknown how multiple lifestyle factors interact to influence cognition. The ACTIVate Study aims to 1) Explore associations between 24-hour time-use and diet compositions with changes in cognition and brain function; and 2) Identify durations of time-use behaviours and the dietary compositions to optimise cognition and brain function. Methods and analysis This three-year prospective longitudinal cohort study will recruit 448 adults aged 60-70 years across Adelaide and Newcastle, Australia. Time-use data will be collected through wrist-worn activity monitors and the Multimedia Activity Recall for Children and Adults (MARCA). Dietary intake will be assessed using the Australian Eating Survey food frequency questionnaire. The primary outcome will be cognitive function, assessed using the Addenbrooke's Cognitive Examination-III (ACE-III). Secondary outcomes include structural and functional brain measures using Magnetic Resonance Imaging (MRI), cerebral arterial pulse measured with Diffuse Optical Tomography (Pulse-DOT), neuroplasticity using simultaneous Transcranial Magnetic Stimulation (TMS) and Electroencephalography (EEG), and electrophysiological markers of cognitive control using event-related potential (ERP) and time-frequency analyses. Compositional data analysis, testing for interactions between time-point and compositions, will assess longitudinal associations between dependent (cognition, brain function) and independent (time-use and diet compositions) variables. Conclusions The ACTIVate Study will be the first to examine associations between time-use and diet compositions, cognition and brain function. Our findings will inform new avenues for multidomain interventions that may more effectively account for the co-dependence between activity and diet behaviours for dementia prevention. Ethics and dissemination Ethics approval has been obtained from University of South Australia's Human Research Ethics committee (202639). Findings will be disseminated through peer reviewed manuscripts, conference presentations, targeted media releases and community engagement events. Registration Details: Australia New Zealand Clinical Trials Registry (ACTRN12619001659190).

scholarly journals Changes in rearfoot strike patterns over childhood

Kinesiology ◽  
2021 ◽  
Vol 53 (2) ◽  
pp. 336-342
Author(s):  
Pedro Ángel Latorre Román ◽  
Juan Antonio Párraga Montilla ◽  
Jeśús Salas Sánchez ◽  
Pedro José Consuegra González
Keyword(s):  
Cohort Study ◽  
Stress Wave ◽  
Age Groups ◽  
The Body ◽  
Longitudinal Cohort Study ◽  
Transient Stress ◽  
Longitudinal Cohort ◽  
Impact Forces ◽  
Prospective Longitudinal ◽  
Prospective Longitudinal Cohort

Rearfoot strike (RFS) in children running produces impact forces that give rise to a transient stress wave traveling through the body. It could contribute to the development of injuries. The purpose of this study was to determine RFS prevalence during childhood while running at a self-selected velocity in a prospective longitudinal cohort study. A total of 175 children (68 girls), aged 6 to 14 years, participated in this study. The sample was divided into three age groups (age in 2016): 6-8 years, 9-11 years, and 12-14 years which were analysed three years later (2019). 2D video-based was used to record the RFS Taking into account all samples, in the jogging trial the prevalence of RFS (an average of both feet) was 86.9% in 2016 and 94.7% three years later; in the running trial the prevalence was 82.6 and 94.4%, respectively. In all samples a significant increase of RFS prevalence was found in both the jogging and running trials for both feet over three years (jogging, left foot, p=.011, right foot, p=.023; running, left foot, p=.001, right foot, p<.001). In girls, there were no significant differences in any conditions. In boys, a significant increase of RFS prevalence was found after three years in both feet (p<.01) in the running trial. This study shows that RFS prevalence in children increases with age and the results may be used to characterize typical running development in children population.

Sign in / Sign up

Export Citation Format

Share Document