Iron deficiency in patients with cancer: a prospective cross-sectional study

BackgroundDespite the deleterious consequences of iron deficiency (ID) in patients with cancer, underdiagnosis is frequent. The CARENFER study aimed to assess the prevalence of ID using both serum ferritin concentration and transferrin coefficient saturation (iron-saturation of transferrin, TSAT) index, as well as ID anaemia in patients with cancer.MethodsThis prospective cross-sectional study was conducted in 15 oncology units in France in 2019. All patients present in the medical unit during the 2-week study period, regardless of the type of tumour (solid or haematological) and treatment, were eligible. Serum ferritin concentration, TSAT index and haemoglobin level were determined. ID and ID-associated anaemia were defined according to European Society of Medical Oncology 2018 Guidelines: ID was defined either as ferritin <100 µg/L (absolute ID) or as ferritin ≥100 µg/L and TSAT <20% (functional ID).ResultsA total of 1221 patients with different types of solid malignant tumours were analysed: median age 64 years; 89.4% under treatment for their cancer, mainly by chemotherapy (75.4%). Overall, ID was found in 57.9% (55.1–60.6) of patients. Among them, functional ID accounted for 64% of cases. ID anaemia was reported in 21.8% (19.6–24.2) of all patients with cancer. ID was highly prevalent in untreated (75/130, 57.4%) and non-anaemic (419/775, 54.1%) patients.ConclusionThis study highlights the high prevalence of ID in patients with cancer, whether or not associated with anaemia or treatment. These results emphasise the need to a better detection and management of ID in cancer, thereby optimising overall patient care.Trial registration numberClinicalTrials.gov Identifier: NCT03924271.

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Iron deficiency among pregnant women attending an antenatal clinic in Northern Uganda: a cross-sectional study

10.21203/rs.2.14386/v1 ◽

2019 ◽

Author(s):

Samson Udho ◽

Joyce Nankumbi ◽

Mariam Namutebi ◽

Grace Ndeezi ◽

Joshua Epuitai ◽

...

Keyword(s):

Iron Deficiency ◽

Pregnant Women ◽

Serum Ferritin ◽

Antenatal Clinic ◽

Cross Sectional Study ◽

Sectional Study ◽

Third Trimester ◽

Cross Sectional ◽

Iron Supplements ◽

The Third

Abstract Background Iron deficiency is a leading cause of anemia among pregnant women in Uganda. However, due to the high cost of biochemical tests required to determine iron deficiency, the prevalence and factors associated with iron deficiency remain largely unstudied in our setting. Therefore, this study aimed at determining the prevalence of iron deficiency and its associated factors among pregnant women attending an antenatal clinic, Lira District-Uganda.Methods A cross-sectional study was conducted among 320 pregnant women attending an antenatal clinic at Lira Regional Referral Hospital. Maternal serum ferritin was used as a measure of iron deficiency and was determined using a Cobas 6000 Automated Analyzer. Iron deficiency was based on serum ferritin of <30 μg/L. A semi-structured questionnaire was used to obtain the characteristics of the study participants. Binary and multivariate logistic regression were performed to identify the associated factors.Results The prevalence of iron deficiency was 45%. Non-adherence to iron supplements (AOR: 2.05 95% CI: 1.02-4.12) & third trimester pregnancy (AOR: 1.88 95% CI: 1.20-2.94) were significantly associated with iron deficiency during pregnancy.Conclusion Nearly 5 in 10 of the participants had iron deficiency. Iron deficiency during pregnancy was associated with non-adherence to iron supplements and being in the third trimester of pregnancy. Midwives should encourage pregnant women to adhere to iron supplements during pregnancy especially pregnant women who are in the third trimester.

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Iron deficiency anemia among hospitalized children in a rural teaching hospital: a cross sectional study

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20182579 ◽

2018 ◽

Vol 5 (4) ◽

pp. 1631

Author(s):

Inderpreet Santokh ◽

Bablu Kumar Gaur ◽

Raghvendra Narayan ◽

Baljeet Maini ◽

A. K. Bharadwaj

Keyword(s):

Socioeconomic Status ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Serum Ferritin ◽

Cross Sectional Study ◽

Hemoglobin Level ◽

Deficiency Anemia ◽

Sectional Study ◽

Cross Sectional ◽

Low Socioeconomic

Background: Iron deficiency anemia is the most common nutritional deficiency disorder in the world. The present study was conducted to know the prevalence and severity of iron deficiency anemia among of 6 months to 60 months old children. A large proportion of iron deficiency is preventable with appropriate and timely intervention.Methods: This cross-sectional study was done on 100 children clinically suggestive of anemia with hemoglobin level less than 11gm/dl admitted in pediatrics ward of tertiary care hospital. 5 ml of blood sample was taken and complete hemogram, peripheral blood film and serum ferritin estimation was done. Case were studied in reference to history, age, clinical examination, hemoglobin level and confirmation of iron deficiency anemia was done by serum ferritin levels.Results: The prevalence of iron deficiency anemia in present study was 56%. It was most prevalent in the age group of 6 to 24 months. Exclusively breastfed children showed higher prevalence of iron deficiency anemia in present study, however no statistical correlation was found. Low Serum ferritin levels have statistically significant result with socioeconomic status, with as many as 69.4% suffering from iron deficiency anemia belonging to low socioeconomic status.Conclusions: Prevalence of iron deficiency anemia remains alarmingly high and major health problem in our country. All anemia are not iron deficiency anemia. Low socioeconomic status is a huge hurdle in child health and greatly influences prevalence of iron deficiency anemia. Serum ferritin is a most sensitive marker of iron deficiency anemia, helps diagnose it early in its course, which can be missed on clinical or routine blood investigations.

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