A reappraisal of digoxin usage

Serum Digoxin ◽

Treat Heart Failure

Digoxin is widely used to treat heart failure and atrial fibrillation. Toxicity from the drug is common1 2 and dangerous, and it is therefore important to consider whether it can be avoided by careful prescribing and a knowledge of the serum digoxin concentration.

Influence of physical exercise on serum digoxin concentration and heart rate in patients with atrial fibrillation.

Heart ◽

10.1136/hrt.65.6.337 ◽

1991 ◽

Vol 65 (6) ◽

pp. 337-341 ◽

Cited By ~ 14

Author(s):

H E Botker ◽

P Toft ◽

N A Klitgaard ◽

E E Simonsen

Keyword(s):

Atrial Fibrillation ◽

Heart Rate ◽

Physical Exercise ◽

Digoxin Concentration ◽

Predictive performance of serum digoxin concentration in patients with congestive heart failure by a hyperbolic model based on creatinine clearance

Journal of Clinical Pharmacy and Therapeutics ◽

10.1046/j.1365-2710.2002.00418.x ◽

2002 ◽

Vol 27 (4) ◽

pp. 257-265 ◽

Cited By ~ 10

Author(s):

H. Konishi ◽

S. Shimizu ◽

M. Chiba ◽

T. Minouchi ◽

M. Koida ◽

...

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Creatinine Clearance ◽

Digoxin Concentration ◽

Predictive Performance ◽

Hyperbolic Model ◽

Model Based ◽

Serum digoxin concentration and the efficacy of digoxin therapy in the treatment of heart failure

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(03)81808-9 ◽

2003 ◽

Vol 41 (6) ◽

pp. 164

Author(s):

Saif S. Rathore ◽

Jeptha P. Curtis ◽

Yongfei Wang ◽

Harlan M. Krumholz

Keyword(s):

Heart Failure ◽

Digoxin Concentration ◽

Serum Digoxin ◽

Digoxin Therapy

P318 Lower serum digoxin concentration and heart failure in Chinese: a prospective cohort study

International Journal of Cardiology ◽

10.1016/s0167-5273(08)70229-8 ◽

2008 ◽

Vol 125 ◽

pp. S56

Author(s):

X.J. Zhao ◽

Z. Peng ◽

L. Qu ◽

J.Q. Wang ◽

L.J. Li

Keyword(s):

Heart Failure ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Digoxin Concentration ◽

Lower Serum ◽

Serum digoxin concentration and outcomes in women with heart failure: A bi-directional effect and a possible effect modification by ejection fraction

European Journal of Heart Failure ◽

10.1016/j.ejheart.2005.10.002 ◽

2006 ◽

Vol 8 (4) ◽

pp. 409-419 ◽

Cited By ~ 22

Author(s):

Ali Ahmed ◽

Inmaculada B. Aban ◽

Michael T. Weaver ◽

Wilbert S. Aronow ◽

Jerome L. Fleg

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Digoxin Concentration ◽

Effect Modification ◽

Directional Effect ◽

The relation of quinidine-Induced elevation of serum digoxin concentration to the conversion of atrial fibrillation-flutter: A pilot study

Cardiovascular Drugs and Therapy ◽

10.1007/bf01869583 ◽

1989 ◽

Vol 3 (6) ◽

pp. 929-930

Author(s):

Sumatilal Shah ◽

Howard S. Friedman

Keyword(s):

Atrial Fibrillation ◽

Pilot Study ◽

Digoxin Concentration ◽

Relationship between serum digoxin concentration and outcome in chronic heart failure

Nature Clinical Practice Cardiovascular Medicine ◽

10.1038/ncpcardio0464 ◽

2006 ◽

Vol 3 (3) ◽

pp. 118-118

Author(s):

Rebecca Ireland

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Digoxin Concentration ◽

Digoxin–Itraconazole Interaction: Possible Mechanisms

Annals of Pharmacotherapy ◽

10.1177/106002809703100410 ◽

1997 ◽

Vol 31 (4) ◽

pp. 438-440 ◽

Cited By ~ 28

Author(s):

Christopher P Alderman ◽

Peter D Allcroft

Keyword(s):

Atrial Fibrillation ◽

Combination Therapy ◽

Digoxin Concentration ◽

Tubular Secretion ◽

Case Summary ◽

Serum Digoxin ◽

Apparent Decrease ◽

Digoxin Clearance ◽

Urinary Digoxin

Objective To document a case in which the administration of itraconazole was associated with an apparent decrease in digoxin clearance, resulting in an increase in the serum digoxin concentration. Case Summary A man receiving digoxin for atrial fibrillation was concurrently treated with itraconazole 200 mg/d for esophageal candidiasis. The estimated urinary digoxin clearance was decreased during this combination therapy. Discussion Digoxin is primarily cleared by the kidneys, and the mechanism of renal clearance involves both glomerular filtration and tubular secretion. We postulate that itraconazole or a metabolite of this compound may have resulted in decreased tubular secretion of digoxin, accounting for decreased urinary digoxin clearance. Conclusions Monitoring of serum digoxin concentrations should be performed if patients taking digoxin are treated with itraconazole. Further investigation is necessary to elucidate the nature of the interaction between digoxin and itraconazole.