scholarly journals Earlier onset and increased risk of Alzheimer's disease in Down's syndrome was associated with sex and apolipoprotein E genotype

1998 ◽  
Vol 1 (4) ◽  
pp. 125-125
Author(s):  
A Langa
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Increased Risk ◽  
Apolipoprotein E Genotype

Apolipoprotein E Genotype and its Effect on Duration and Severity of Early and Late Onset Alzheimer's Disease

1995 ◽  
Vol 167 (4) ◽  
pp. 533-536 ◽  
Author(s):  
Jennie Norrman ◽  
Anthony J. Brookes ◽  
Celia Yates ◽  
David St Clair
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Late Onset ◽  
Apoe Genotype ◽  
Increased Risk ◽  
Apolipoprotein E Genotype

BackgroundThe apolipoprotein E (ApoE) ∊4 allele is associated with an increased risk of senile and probably presenile Alzheimer's disease. It is not yet clear whether the ∊4 allele also influences the duration/rate of progress of illness and the severity of the dementia.MethodWe have retrospectively examined a series of ApoE genotyped presenile and senile autopsy cases of Alzheimer's disease (AD) for length of illness and severity of pathology.ResultsWe find no evidence that ApoE genotype affects the rate of progress of AD, but the degree of pathology at death may be increased.ConclusionIt appears that the rate of progress of AD as a whole is independent of the ApoE genotype.

Down's syndrome and dementia

2004 ◽  
Vol 10 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Lisa R. Stanton ◽  
Rikus H. Coetzee
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Disorder ◽  
Down's Syndrome ◽  
Acetylcholinesterase Inhibitors ◽  
Down’S Syndrome ◽  
Chromosome 21 ◽  
Unique Challenge ◽  
Increased Risk ◽  
New Treatments

Down's syndrome is the most common genetic disorder seen in clinical practice: about 94% occurs because of non-disjunction of chromosome 21 and 3–5% because of translocation. Individuals increasingly survive to middle and old age, probably because of advances in medical treatment and improved living conditions. People with Down's syndrome have an increased risk of developing Alzheimer's disease in middle age. Within ICD–10 and DSM–IV classifications there is no consensus on the diagnosis of dementia in people with learning disability. New treatments have been licensed for use in mild to moderate Alzheimer's disease (e.g. acetylcholinesterase inhibitors and memantine). The comorbid picture of Down's syndrome and Alzheimer's disease presents a unique challenge to the clinician in both diagnosis and management.

The influence of apolipoprotein E isotypes on alzheimer's disease pathology in 40 cases of down's syndrome

1995 ◽  
Vol 37 (1) ◽  
pp. 136-138 ◽  
Author(s):  
Thomas Wisniewski ◽  
Laura Morelli ◽  
J. Wegiel ◽  
Efrat Levy ◽  
H. M. Wisniewski ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Down's Syndrome ◽  
Down’S Syndrome

Increased risk of Alzheimer's disease in mothers of adults with Down's syndrome

The Lancet ◽  
1994 ◽  
Vol 344 (8929) ◽  
pp. 1092-1095 ◽  
Author(s):  
S-J Richards ◽  
A Holland ◽  
C.R Palmer ◽  
Nicole Schupf ◽  
Deborah Kapell ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Increased Risk
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