E-scooter incidents in Berlin: an evaluation of risk factors and injury patterns

BackgroundE-scooters have emerged as a frequently used vehicle in German cities due to their high availability and easy access. However, investigations about the causes and mechanisms of E-scooter incidents and their trauma-specific consequences are rare.MethodsWe analysed all patients involved in E-scooter incidents from June to December 2019 who presented to four inner-city EDs in Berlin. The prospective data included patient-related and incident-related data, information on injury patterns and therapy, responses in a voluntary questionnaire concerning E-scooter use and general traffic experience.Results248 patients (129 males; median age 29 years (5–81)) were included: 41% were tourists and 4% were children. Most incidents (71%) occurred between July and September 2019, the majority occurring at weekends (58%). The injury pattern was mostly multifocal, affecting the lower (42%) and upper limbs (37%) and the head (40%). Traumatic brain injury was associated with alcohol consumption. Inpatient admission was recorded in 25%, surgery in 23%.ConclusionThis study has defined the incidence of injury related to E-scooter use in a major European city. Stricter laws governing the use of E-scooters, the wearing of helmets and technical modifications to the E-scooter platforms might decrease E-scooter-associated incidents and resulting injuries in the future.Trial registration numberGerman Clinical Trials Registry (DRKS00018061).

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BRENDA, the ELIXIR core data resource in 2021: new developments and updates

Nucleic Acids Research ◽

10.1093/nar/gkaa1025 ◽

2020 ◽

Vol 49 (D1) ◽

pp. D498-D508

Author(s):

Antje Chang ◽

Lisa Jeske ◽

Sandra Ulbrich ◽

Julia Hofmann ◽

Julia Koblitz ◽

...

Keyword(s):

Intracellular Localization ◽

Easy Access ◽

New Developments ◽

Data Resource ◽

Core Data ◽

Related Data ◽

Primary Literature ◽

Ligand Interactions ◽

Genome Annotations ◽

Individual Enzyme

Abstract The BRENDA enzyme database (https://www.brenda-enzymes.org), established in 1987, has evolved into the main collection of functional enzyme and metabolism data. In 2018, BRENDA was selected as an ELIXIR Core Data Resource. BRENDA provides reliable data, continuous curation and updates of classified enzymes, and the integration of newly discovered enzymes. The main part contains >5 million data for ∼90 000 enzymes from ∼13 000 organisms, manually extracted from ∼157 000 primary literature references, combined with information of text and data mining, data integration, and prediction algorithms. Supplements comprise disease-related data, protein sequences, 3D structures, genome annotations, ligand information, taxonomic, bibliographic, and kinetic data. BRENDA offers an easy access to enzyme information from quick to advanced searches, text- and structured-based queries for enzyme-ligand interactions, word maps, and visualization of enzyme data. The BRENDA Pathway Maps are completely revised and updated for an enhanced interactive and intuitive usability. The new design of the Enzyme Summary Page provides an improved access to each individual enzyme. A new protein structure 3D viewer was integrated. The prediction of the intracellular localization of eukaryotic enzymes has been implemented. The new EnzymeDetector combines BRENDA enzyme annotations with protein and genome databases for the detection of eukaryotic and prokaryotic enzymes.

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Variability of outcome measures in trials of intravenous therapy in acute severe paediatric asthma: a systematic review

Emergency Medicine Journal ◽

10.1136/emermed-2018-207929 ◽

2018 ◽

Vol 36 (4) ◽

pp. 225-230 ◽

Cited By ~ 3

Author(s):

Charmaine S Gray ◽

Colin V E Powell ◽

Franz E Babl ◽

Stuart R Dalziel ◽

Simon Craig

Keyword(s):

Length Of Stay ◽

Outcome Measures ◽

Treatment Modalities ◽

International Consensus ◽

Paediatric Asthma ◽

Study Protocols ◽

Registration Number ◽

Secondary Outcomes ◽

Clinical Trials Registry ◽

Bedside Tests

ObjectiveTo determine the variability of primary and secondary outcomes used in trials of intravenous bronchodilators in children with acute severe paediatric asthma.MethodsSystematic search of MEDLINE, EMBASE, Cochrane CENTRAL and the WHO International Clinical Trials Registry Platform for randomised trials in children (less than18 years) with acute severe paediatric asthma comparing intravenous bronchodilator therapy to another treatment. Initial search was performed on 7 January 2016 with an updated search performed on 6 September 2018. Primary and secondary outcomes were collated.ResultsWe identified 35 published papers and four registered study protocols. 56 primary outcomes were found, the most common being a clinical asthma score (23/56; 41%). Other identified primary outcomes included bedside tests of respiratory function (11/56; 20%) and measures of length of stay (9/56; 16%). There were a total of 60 different secondary outcomes, the most common were various length of stay measures (24/60; 40%) and adverse events (11/60; 18%).ConclusionStudies comparing intravenous treatment modalities for children with acute severe paediatric asthma exhibit great variation in the type, number and timing of outcome measures used. There are no patient or family-specific outcomes reported. There is a need to develop international consensus.Trial registration numberCRD42017055331.

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Attribution of non-ClinicalTrials.gov registries among WHO International Clinical Trials Registry Platform-registered trials from 2014 to 2018: A protocol for a meta-epidemiological study

10.7287/peerj.preprints.27298v1 ◽

2018 ◽

Author(s):

Masahiro Banno ◽

Yasushi Tsujimoto ◽

Yuki Kataoka

Keyword(s):

Clinical Trials ◽

Epidemiological Study ◽

Medical Information ◽

University Hospital ◽

World Health ◽

Study Phase ◽

Target Sample Size ◽

Registration Number ◽

Health Organization ◽

Clinical Trials Registry

Background. The attribution of non-ClinicalTrials.gov registries among registered trials of the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) had increased until 2013. However, the attribution after 2013 is unknown. Moreover, no study has investigated the usage of non-ClinicalTrials.gov registries after 2015 or compared the characteristics of trials under non-ClinicalTrials.gov and ClinicalTrials.gov registries. Methods. This will be a meta-epidemiological study. It will include all trials registered on the ICTRP from January 1, 2014, to December 31, 2018. First, we will describe the total attribution of non-ClinicalTrials.gov registries among the ICTRP-registered trials for each year and each registry worldwide. Second, we will compare the recruitment status, target sample size, study type, study design, countries, prospective registration, funding, and study phase of the trials on ClinicalTrials.gov and other registries from 2014 to 2018. Third, we will report on the distribution of primary registries of trials from the top five countries in order of the quantity of registered trials on the ICTRP. Ethics & Dissemination. Ethics approval is not required for this study. This protocol has been registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR). The findings will be published in a peer-reviewed journal and may be presented at conferences. Trial Registration Number. UMIN000034401

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Learning Communities in the City: Social Constructivism, Spaces and Connections in the New Urban Primary School

10.26686/wgtn.16985227 ◽

2021 ◽

Author(s):

◽

James Silverwood

Keyword(s):

Inner City ◽

Primary School ◽

Social Constructivism ◽

Educational Theory ◽

Easy Access ◽

School Design ◽

Living Room ◽

School Building ◽

Demographic Shift ◽

The City

The main intention of the research is to develop a model for an inner city primary school building which is responsive to the urban context and reflects the educational theory of Social Constructivism. The underlying demand for an inner city primary school was identified as a result of a recent demographic shift which involves more families living in the centres of New Zealand’s cities. Schools are an important part of a city’s infrastructure, where quality schools can help to develop quality cities. There should be a close fit between current educational theory and contemporary school design. Social Constructivism views learning as the construction of knowledge through social interaction with peers, adults and the environment. The design case study proposes a vertical school that is capable of supporting strong links with the community through developing a ‘public living room’ alongside retail outlets. While the vertical nature of the school limits some contact it is possible to develop a ‘learning street’ and other meeting places within the school. The plan also provides flexible classroom spaces and workrooms to meet curriculum objectives. A variety of indoor and outdoor spaces can be provided but it is proposed that the children also access the city’s public open spaces and amenities. The city can be viewed as an extended classroom, as suggested in Strickland’s ‘City of Learning’ model. The site for the proposed school was selected to ensure easy access to amenities and resources. Overall the research suggests an inner-city primary school building is possible and even desirable for those living and working in the city.

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Reurbanisation in Postsocialist Europe – A Comparative View of Eastern Germany, Poland, and the Czech Republic

Comparative Population Studies ◽

10.12765/cpos-2018-02 ◽

1970 ◽

Vol 42 ◽

Author(s):

Annegret Haase ◽

Manuel Wolff ◽

Petra Špačková ◽

Adam Radzimski

Keyword(s):

Czech Republic ◽

Inner City ◽

National Scale ◽

The Czech Republic ◽

Large Cities ◽

Eastern Germany ◽

East German ◽

Lively Debate ◽

The Uk ◽

German Cities

Since the 1990s, reurbanisation has become an increasingly frequent trajectory for urban development. Many formerly shrinking cities have been able to stabilise their population or even see new growth. Especially prominent in regions like Germany and the UK, but also observed across the whole continent, a lively debate on reurbanisation has developed as a reality of today’s, and a potential trajectory for tomorrow’s, cities in Europe.Postsocialist Europe has not so far been central in the reurbanisation debate, either empirically or theoretically. Subsequently, the postsocialist experience is missing in the discourse and the existing body of evidence. There is, however, some evidence that Czech and Polish cities are also seeing signs of new inner-city growth and a trend towards core city stabilisation.Against this background, the paper scrutinises the issues of reurbanisation and new growth after the shrinking of postsocialist cities. The paper uses the approach of a contrastive comparison between cities in eastern Germany, where reurbanisation has developed as the predominant trajectory for many large cities, and for cities in Poland and the Czech Republic, where this trend is considerably less prominent. It analyses the development of reurbanisation in these cities and their urban regions over the last few decades, its characteristics and the determinants triggering or impeding it. The paper includes data on a national scale as well as from relevant case studies of cities and their urban regions.It argues, among other things, that there is no “postsocialist model” with regard to influencing factors for reurbanisation. Eastern Germany, due to its specific postsocialist situation and transformation trajectory, can be viewed as an “outlier” or “hybrid” which exhibits characteristics typical of postsocialist and western welfare contexts and which is seeing especially dynamic reurbanisation after a phase of extreme shrinkage. Although there are clear signs of inner-city reurbanisation in Polish and Czech cities as well, it seems relatively unlikely that this process will reach the same high levels as in East German cities within the coming years. * This article belongs to a special issue on reurbanisation.

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Statistical analysis plan (SAP) for the Very Early Rehabilitation in Speech (VERSE) after stroke trial: an international 3-arm clinical trial to determine the effectiveness of early, intensive, prescribed, direct aphasia therapy

International Journal of Stroke ◽

10.1177/1747493018790055 ◽

2018 ◽

Vol 13 (8) ◽

pp. 863-880 ◽

Cited By ~ 1

Author(s):

Erin Godecke ◽

Tapan Rai ◽

Dominique A Cadilhac ◽

Elizabeth Armstrong ◽

Sandy Middleton ◽

...

Keyword(s):

Clinical Trials ◽

Statistical Analysis ◽

Statistical Analysis Plan ◽

Steering Committee ◽

Aphasia Therapy ◽

Detailed Statistical Analysis ◽

Registration Number ◽

Clinical Trials Registry ◽

Potential Trial ◽

Stroke Trial

Background Limited evidence exists to support very early intensive aphasia rehabilitation after stroke. VERSE is a PROBE trial designed to determine whether two types of intensive aphasia therapy, beginning within 14 days of acute stroke, provide greater therapeutic and cost-effectiveness than usual care. Objective To publish the detailed statistical analysis plan for the VERSE trial prior to unblinding. This statistical analysis plan was based on the published and registered VERSE trial protocol and was developed by the blinded steering committee and management team, led by the trial statistician. This plan was developed using outcome measures and trial data collection forms. Results The VERSE statistical analysis plan is consistent with reporting standards for clinical trials and provides for clear and open reporting. Conclusions Publication of a statistical analysis plan serves to reduce potential trial reporting bias and outlines transparent pre-specified analyses. Australian New Zealand Clinical Trials Registry (ANZCTR) Registration number: ACTRN12613000776707; Universal Trial Number (UTN) is U1111-1145-4130.

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Acupuncture for poststroke hemiplegia focusing on cerebral bilateral connections: study protocol for a randomised controlled neuroimaging trial

BMJ Open ◽

10.1136/bmjopen-2019-034548 ◽

2020 ◽

Vol 10 (4) ◽

pp. e034548 ◽

Cited By ~ 1

Author(s):

Lan Jiang ◽

Hualei Geng ◽

Mengxin Lu ◽

Zhongming Du ◽

Pei Chen ◽

...

Keyword(s):

Motor Function ◽

Gray Matter Volume ◽

Underlying Mechanism ◽

Motor Dysfunction ◽

Brain Response ◽

Before And After ◽

Neuroimaging Data ◽

Registration Number ◽

Randomised Controlled ◽

Clinical Trials Registry

IntroductionAcupuncture is safe and effective for improving the motor function of poststroke hemiplegic patients, but there still exists a certain gap between clinical practice and understanding its neural mechanisms. The cerebral functional reconstruction after unilateral motor pathway injury exhibits a bilateral tendency, however current studies seldom pay attention to it. Hence, based on cerebral bilateral connections, the underlying mechanism of acupuncture in stroke rehabilitation remains an area for further research. The results of this study will increase our understanding of acupuncture-induced motor recovery in patients who had suffered a stroke and demonstrate the differences in brain response and clinical assessments.Methods and analysisThis is a single-centre, randomised controlled, paralleled neuroimaging trial, with patients and outcome assessors blinded. Thirty patients who had a stroke with motor dysfunction meeting the inclusion criteria will be randomly assigned (2:1) to receive either 10 sessions true or sham acupoints treatments (five sessions per week for 2 weeks). All the participants will receive conventional standard medical care and rehabilitation. Motor function assessments and neuroimaging scanning will be conducted before and after the entire acupuncture treatment. The clinical and neuroimaging data will be analysed, respectively. The voxel-mirrored homotopic connectivity will be the primary outcome and the primary effect indicator. The secondary outcomes comprise clinical evaluations and neuroimaging assessments, which include Fugl-Meyer Assessment, the National Institutes of Health Stroke Scale, fractional anisotropy and gray matter volume. The Needle Sensation Assessment Scale is an additional outcome. The correlation analysis will be explored between the neuroimaging indicators, clinical motor assessments and needle sensation.Ethics and disseminationThe protocol has been approved by the ethics committee of Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine (DZMEC-KY-2018-04). The results of the neuroimaging trial will be disseminated through peer-reviewed publications and conferences.Trial registration numberChinese Clinical Trials Registry (ChiCTR 1800016263).

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Pharmacokinetics and Ex Vivo Antimalarial Activity of Artesunate-Amodiaquine plus Methylene Blue in Healthy Volunteers

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.01441-19 ◽

2020 ◽

Vol 64 (3) ◽

Cited By ~ 1

Author(s):

Chu Xuan Anh ◽

Marina Chavchich ◽

Geoffrey W. Birrell ◽

Karin Van Breda ◽

Thomas Travers ◽

...

Keyword(s):

Methylene Blue ◽

Antimalarial Activity ◽

Ex Vivo ◽

Area Under The Curve ◽

Plasma Samples ◽

Open Label ◽

Content Type ◽

Registration Number ◽

Clinical Trials Registry

ABSTRACT High rates of artemisinin-based combination therapy (ACT) failures in the treatment of Plasmodium falciparum malaria in Southeast Asia have led to triple-drug strategies to extend the useful life of ACTs. In this study, we determined whether methylene blue [MB; 3,7-bis(dimethylamino)phenothiazin-5-ium chloride hydrate] alters the pharmacokinetics of artesunate-amodiaquine (ASAQ) and enhances the ex vivo antimalarial activity of ASAQ. In an open-label, randomized crossover design, a single oral dose of ASAQ (200 mg AS/540 mg AQ) alone or with MB (325 mg) was administered to 15 healthy Vietnamese volunteers. Serial blood samples were collected up to 28 days after dosing. Pharmacokinetic properties of the drugs were determined by noncompartmental analysis. After drug administration, plasma samples from seven participants were assessed for ex vivo antimalarial activity against the artemisinin-sensitive MRA1239 and the artemisinin-resistant MRA1240 P. falciparum lines, in vitro. MB significantly increased the mean area under the curve of the active metabolite of AS, dihydroartemisinin (1,246 ± 473 versus 917 ± 405 ng·h/ml, P = 0.009) but did not alter the pharmacokinetics of AQ, AS, or desethylamodiaquine. Comparing the antimalarial activities of the plasma samples from the participants collected up to 48 h after ASAQ plus MB (ASAQ+MB) and ASAQ dosing against the MRA1239 and MRA1240 lines, MB significantly enhanced the blood schizontocidal activity of ASAQ by 2.0-fold and 1.9-fold, respectively. The ring-stage survival assay also confirmed that MB enhanced the ex vivo antimalarial activity of ASAQ against MRA1240 by 2.9-fold to 3.8-fold, suggesting that the triple-drug combination has the potential to treat artemisinin-resistant malaria and for malaria elimination. (This study has been registered in the Australian New Zealand Clinical Trials Registry [https://anzctr.org.au/] under registration number ACTRN12612001298808.)

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Learning Communities in the City: Social Constructivism, Spaces and Connections in the New Urban Primary School

10.26686/wgtn.16985227.v1 ◽

2021 ◽

Author(s):

◽

James Silverwood

Keyword(s):

Inner City ◽

Primary School ◽

Social Constructivism ◽

Educational Theory ◽

Easy Access ◽

School Design ◽

Living Room ◽

School Building ◽

Demographic Shift ◽

The City

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LINKING 3D BUILDING MODELS, MAPS AND ENERGY-RELATED DATA IN A WEB-BASED VISUALIZATION SYSTEM

ISPRS Annals of Photogrammetry Remote Sensing and Spatial Information Sciences ◽

10.5194/isprs-annals-iv-4-w7-129-2018 ◽

2018 ◽

Vol IV-4/W7 ◽

pp. 129-134

Author(s):

R. Sihombing ◽

V. Coors

Keyword(s):

Measurement Data ◽

Transformation Process ◽

Environmental Data ◽

Geospatial Data ◽

Easy Access ◽

Web Browser ◽

Existing Building ◽

Visualization System ◽

Related Data ◽

2D And 3D

Abstract. In a transformation process to become a climate-neutral city campus, universities have to deal with the sustainable concept. Since “human factor” plays a significant role in the transformation process, providing easy access to environmental data to influence building occupants’ behavior is essential. By utilizing energy-related data without spatial attribute and existing building geospatial data, data visualization in a web browser can be established for both 2D and 3D platforms. Our implementation presents a visualization of indoor sensor measurement data, where the same geospatial data can be used for both 2D and 3D visualizations even though the 3D platform needs an adjustment. Our approach results in a monitoring tool prototype based on visualization of indoor sensors measurement data, which can be accessed easily in a web browser by all building occupants.

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