scholarly journals BRENDA, the ELIXIR core data resource in 2021: new developments and updates

2020 ◽  
Vol 49 (D1) ◽  
pp. D498-D508
Author(s):  
Antje Chang ◽  
Lisa Jeske ◽  
Sandra Ulbrich ◽  
Julia Hofmann ◽  
Julia Koblitz ◽  
...  
Keyword(s):  
Intracellular Localization ◽  
Easy Access ◽  
New Developments ◽  
Data Resource ◽  
Core Data ◽  
Related Data ◽  
Primary Literature ◽  
Ligand Interactions ◽  
Genome Annotations ◽  
Individual Enzyme

Abstract The BRENDA enzyme database (https://www.brenda-enzymes.org), established in 1987, has evolved into the main collection of functional enzyme and metabolism data. In 2018, BRENDA was selected as an ELIXIR Core Data Resource. BRENDA provides reliable data, continuous curation and updates of classified enzymes, and the integration of newly discovered enzymes. The main part contains >5 million data for ∼90 000 enzymes from ∼13 000 organisms, manually extracted from ∼157 000 primary literature references, combined with information of text and data mining, data integration, and prediction algorithms. Supplements comprise disease-related data, protein sequences, 3D structures, genome annotations, ligand information, taxonomic, bibliographic, and kinetic data. BRENDA offers an easy access to enzyme information from quick to advanced searches, text- and structured-based queries for enzyme-ligand interactions, word maps, and visualization of enzyme data. The BRENDA Pathway Maps are completely revised and updated for an enhanced interactive and intuitive usability. The new design of the Enzyme Summary Page provides an improved access to each individual enzyme. A new protein structure 3D viewer was integrated. The prediction of the intracellular localization of eukaryotic enzymes has been implemented. The new EnzymeDetector combines BRENDA enzyme annotations with protein and genome databases for the detection of eukaryotic and prokaryotic enzymes.

scholarly journals BRENDA in 2019: a European ELIXIR core data resource

2018 ◽  
Vol 47 (D1) ◽  
pp. D542-D549 ◽  
Author(s):  
Lisa Jeske ◽  
Sandra Placzek ◽  
Ida Schomburg ◽  
Antje Chang ◽  
Dietmar Schomburg
Keyword(s):  
Data Resource ◽  
Core Data

Wharton Research Data Services (WRDS)

2021 ◽  
Vol 22 (3) ◽  
pp. 46-51
Author(s):  
Breezy Silver
Keyword(s):  
Graduate Students ◽  
Research Data ◽  
Complex Data ◽  
Limited Data ◽  
Data Resource ◽  
Data Services ◽  
Related Data ◽  
Subject Areas ◽  
Data Coverage ◽  
Using Data

Wharton Research Data Services (WRDS) is a unique, complex data resource popular with academia but also utilized in government agencies, nonprofits, and corporations. It contains financial and accounting related data and tools but also includes limited data from some other subject areas like healthcare and marketing. WRDS provides the interface to access datasets with limited datasets included and then individual datasets may also be purchased. WRDS makes accessing and using data easier for users, but it also depends on users having enough experience in the field to be familiar with the various vendors and data coverage. Within academia, faculty and graduate students may have an easier time even though undergraduates are permitted access. While it is complicated, it does ease some of the burdens of working with data. Because it is focused on data, it allows users to find and use data with less limitations that users may encounter with regular business databases.

scholarly journals LINKING 3D BUILDING MODELS, MAPS AND ENERGY-RELATED DATA IN A WEB-BASED VISUALIZATION SYSTEM

2018 ◽  
Vol IV-4/W7 ◽  
pp. 129-134
Author(s):  
R. Sihombing ◽  
V. Coors
Keyword(s):  
Measurement Data ◽  
Transformation Process ◽  
Environmental Data ◽  
Geospatial Data ◽  
Easy Access ◽  
Web Browser ◽  
Existing Building ◽  
Visualization System ◽  
Related Data ◽  
2D And 3D

<p><strong>Abstract.</strong> In a transformation process to become a climate-neutral city campus, universities have to deal with the sustainable concept. Since “human factor” plays a significant role in the transformation process, providing easy access to environmental data to influence building occupants’ behavior is essential. By utilizing energy-related data without spatial attribute and existing building geospatial data, data visualization in a web browser can be established for both 2D and 3D platforms. Our implementation presents a visualization of indoor sensor measurement data, where the same geospatial data can be used for both 2D and 3D visualizations even though the 3D platform needs an adjustment. Our approach results in a monitoring tool prototype based on visualization of indoor sensors measurement data, which can be accessed easily in a web browser by all building occupants.</p>

scholarly journals Development of a WebGIS-Based Analysis Tool for Human Health Protection from the Impacts of Prescribed Fire Smoke in Southeastern USA

2019 ◽  
Vol 16 (11) ◽  
pp. 1981 ◽  
Author(s):  
Yongtao Hu ◽  
Ha Hang Ai ◽  
Mehmet Talat Odman ◽  
Ambarish Vaidyanathan ◽  
Armistead G. Russell
Keyword(s):  
Air Quality ◽  
Human Health ◽  
Prescribed Fire ◽  
Prescribed Burning ◽  
Visual Analysis ◽  
Easy Access ◽  
Analysis Tool ◽  
Southeastern Usa ◽  
Related Data ◽  
Fire Information

We have developed the Southern Integrated Prescribed Fire Information System (SIPFIS) to disseminate prescribed fire information, including daily forecasts of potential air quality impacts for southeastern USA. SIPFIS is a Web-based Geographic Information Systems (WebGIS) assisted online analysis tool that provides easy access to air quality and fire-related data products, and it facilitates visual analysis of exposure to smoke from prescribed fires. We have demonstrated that the information that SIPFIS provides can help users to accomplish several fire management activities, especially those related to assessing environmental and health impacts associated with prescribed burning. SIPFIS can easily and conveniently assist tasks such as checking residential community-level smoke exposures for personal use, pre-screening for fire-related exceptional events that could lead to air quality exceedances, supporting analysis for air quality forecasts, and the evaluation of prescribed burning operations, among others. The SIPFIS database is currently expanding to include social vulnerability and human health information, and this will evolve to bring more enhanced interactive functions in the future.

scholarly journals The ELIXIR Core Data Resources: fundamental infrastructure for the life sciences

2019 ◽  
Author(s):  
Rachel Drysdale ◽  
Charles E. Cook ◽  
Robert Petryszak ◽  
Vivienne Baillie-Gerritsen ◽  
Mary Barlow ◽  
...  
Keyword(s):  
Life Science ◽  
Life Sciences ◽  
Health Sector ◽  
Biological Data ◽  
Supplementary Information ◽  
Science Data ◽  
Data Infrastructure ◽  
Data Resource ◽  
Core Data ◽  
The Core

AbstractMotivationLife science research in academia, industry, agriculture, and the health sector depends critically on free and open data resources. ELIXIR (www.elixir-europe.org), the European Research Infrastructure for life sciences data, has identified a set of Core Data Resources within Europe that are of most fundamental importance for the long-term preservation of biological data. We explore characteristics of their usage, impact and assured funding horizon to assess their value and importance as an infrastructure, to understand sustainability of the infrastructure, and to demonstrate a model for assessing Core Data Resources worldwide.ResultsThe nineteen resources currently designated ELIXIR Core Data Resources form a data infrastructure in Europe which is a subset of the worldwide open life science data infrastructure. We show that, from 2014 to 2018, data managed by the Core Data Resources more than tripled while staff numbers increased by less than a tenth. Additionally, support for the Core Data Resources is precarious: together they have assured funding for less than a third of current staff after four years.Our findings demonstrate the importance of the ELIXIR Core Data Resources as repositories for research data and knowledge, while also demonstrating the uncertain nature of the funding environment for this infrastructure. ELIXIR is working towards longer-term support for the Core Data Resources and, through the Global Biodata Coalition, aims to ensure support for the worldwide life science data resource infrastructure of which the ELIXIR Core Data Resources are a [email protected] informationSupplementary data are available at Bioinformatics online.

IGM-Mechanism Encyclopaedia and the Digital Mechanism Library as a Knowledge Base in Mechanism Theory

2006 ◽  
Author(s):  
Burkhard Corves ◽  
Ju¨rgen Niemeyer ◽  
Johannes Kloppenburg
Keyword(s):  
Easy Access ◽  
The Internet ◽  
Success Factor ◽  
New Developments ◽  
Knowledge Presentation ◽  
Acrylic Glass ◽  
Synthesis Of Mechanisms ◽  
Analysis And Synthesis ◽  
New Ideas ◽  
Mechanism Theory

The Institute of Mechanism Theory and Machine Dynamics of RWTH Aachen University houses a large collection of more than 200 mechanisms and models. Partly they are used to illustrate and visualize kinematic basics and methods taught to students. Furthermore these models are also used as a basis for mechanical designers looking for a solution to their motion tasks in different machinery such as packaging or processing machines. These models span a wide arch from historic models showing e.g. sewing machines from the late 19th century, typewriters from the early 20th century and acrylic glass models still used today in university lectures where they are placed on the overhead projector. With the swift development of the internet as the major base for information retrieval, new ideas about knowledge presentation have come up. Today it is obvious that fast and easy access to information is a major success factor in most areas both economics and science and is therefore of eminent importance. New developments in information technology and related software have created new possibilities for the presentation of scientific knowledge also in mechanism theory [1]. In this paper the IGM-Mechanism Encyclopaedia and the Digital Mechanism Library will be presented. Both use the possibilities of the internet to make basic and specific knowledge for the analysis and synthesis of mechanisms available to a broad public.

scholarly journals Public Health Systems and Services Research: Dataset Development, Dissemination, and Use

2009 ◽  
Vol 124 (3) ◽  
pp. 372-377 ◽  
Author(s):  
F. Douglas Scutchfield ◽  
Nikki Lawhorn ◽  
Rick Ingram ◽  
Debra Joy Pérez ◽  
Rick Brewer ◽  
...  
Keyword(s):  
Public Health ◽  
Health Services ◽  
Health Systems ◽  
Easy Access ◽  
Public Health Services ◽  
Services Research ◽  
Data Resource ◽  
Public Health Systems ◽  
The Impact ◽  
Research Resources

Public health systems and services research (PHSSR) is defined as “a field of study that examines the organization, financing, and delivery of public health services within communities and the impact of those services.” PHSSR is a relatively young field and suffers from a paucity of research resources. In this article, we describe the development and utility of a data resource, housed on the Health Services and Sciences Research Resources website maintained by the National Library of Medicine, which provides easy access to instruments, indices, and datasets that are relevant to PHSSR researchers. We also investigate efforts to promote the use and dissemination of these data resources, including the awarding of research grants and the organization of a PHSSR conference.

Biomarkers: Molecular Fossils

1988 ◽  
Vol 1 ◽  
pp. 98-113 ◽  
Author(s):  
Roger E. Summons
Keyword(s):  
Organic Matter ◽  
Organic Compounds ◽  
Recent Progress ◽  
Organic Geochemistry ◽  
New Developments ◽  
Molecular Fossils ◽  
Primary Literature ◽  
History Of ◽  
Biomarker Research ◽  
Made In

Curiosity about the history of life on our planet is a major motivational force for earth scientists. Fossil organic compounds, the components of petroleum and sedimentary organic matter, record aspects of the evolution of the biosphere from as far back as 1.8 billion years and perhaps longer. Elucidation of this record is continually advancing as a result of the concerted interests and efforts of geologists, biologists and chemists. It is also aided by advances in technique and instrumentation. Fascinating new developments and insights abound. In this paper I review some early landmarks and discuss the recent progress made in organic geochemistry, particularly as it applies to biomarker research. The examples of recent work are heavily biased toward my own interests and are not intended to be comprehensive. Because the literature citations are also selective and rely heavily on reviews, readers are advised to seek out the primary literature for accurate detail of specific subjects.

E-scooter incidents in Berlin: an evaluation of risk factors and injury patterns

2021 ◽  
pp. emermed-2020-210268
Author(s):  
Deniz Uluk ◽  
Tobias Lindner ◽  
Michael Dahne ◽  
Jens Werner Bickelmayer ◽  
Kassandra Beyer ◽  
...  
Keyword(s):  
Inner City ◽  
Easy Access ◽  
Injury Patterns ◽  
Prospective Data ◽  
Related Data ◽  
Included Patient ◽  
Registration Number ◽  
Technical Modifications ◽  
Clinical Trials Registry ◽  
German Cities

BackgroundE-scooters have emerged as a frequently used vehicle in German cities due to their high availability and easy access. However, investigations about the causes and mechanisms of E-scooter incidents and their trauma-specific consequences are rare.MethodsWe analysed all patients involved in E-scooter incidents from June to December 2019 who presented to four inner-city EDs in Berlin. The prospective data included patient-related and incident-related data, information on injury patterns and therapy, responses in a voluntary questionnaire concerning E-scooter use and general traffic experience.Results248 patients (129 males; median age 29 years (5–81)) were included: 41% were tourists and 4% were children. Most incidents (71%) occurred between July and September 2019, the majority occurring at weekends (58%). The injury pattern was mostly multifocal, affecting the lower (42%) and upper limbs (37%) and the head (40%). Traumatic brain injury was associated with alcohol consumption. Inpatient admission was recorded in 25%, surgery in 23%.ConclusionThis study has defined the incidence of injury related to E-scooter use in a major European city. Stricter laws governing the use of E-scooters, the wearing of helmets and technical modifications to the E-scooter platforms might decrease E-scooter-associated incidents and resulting injuries in the future.Trial registration numberGerman Clinical Trials Registry (DRKS00018061).

scholarly journals The EU Child Cohort Network’s core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables

2021 ◽  
Author(s):  
Angela Pinot de Moira ◽  
◽  
Sido Haakma ◽  
Katrine Strandberg-Larsen ◽  
Esther van Enckevort ◽  
...  
Keyword(s):  
Statistical Power ◽  
Major Product ◽  
Multiple Birth ◽  
Birth Cohorts ◽  
Data Resource ◽  
Core Data ◽  
Number Of Children ◽  
Analysis Platform ◽  
Early Life Exposures ◽  
The Eu

AbstractThe Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts from across Europe and Australia to facilitate studies on the influence of early-life exposures on later health outcomes. A major product of this collaboration has been the establishment of a FAIR (findable, accessible, interoperable and reusable) data resource known as the EU Child Cohort Network. Here we focus on the EU Child Cohort Network’s core variables. These are a set of basic variables, derivable by the majority of participating cohorts and frequently used as covariates or exposures in lifecourse research. First, we describe the process by which the list of core variables was established. Second, we explain the protocol according to which these variables were harmonised in order to make them interoperable. Third, we describe the catalogue developed to ensure that the network’s data are findable and reusable. Finally, we describe the core data, including the proportion of variables harmonised by each cohort and the number of children for whom harmonised core data are available. EU Child Cohort Network data will be analysed using a federated analysis platform, removing the need to physically transfer data and thus making the data more accessible to researchers. The network will add value to participating cohorts by increasing statistical power and exposure heterogeneity, as well as facilitating cross-cohort comparisons, cross-validation and replication. Our aim is to motivate other cohorts to join the network and encourage the use of the EU Child Cohort Network by the wider research community.

Sign in / Sign up

Export Citation Format

Share Document