PWE-61 An early evaluation of participant recruitment and compliance following the virtualisation of RELIEVE IBS-D trial

As participant recruitment and data collection over the Internet have become more common, numerous observers have expressed concern regarding the validity of research conducted in this fashion. One growing method of conducting research over the Internet involves recruiting participants and administering questionnaires over Facebook, the world’s largest social networking service. If Facebook is to be considered a viable platform for social research, it is necessary to demonstrate that Facebook users are sufficiently heterogeneous and that research conducted through Facebook is likely to produce results that can be generalized to a larger population. The present study examines these questions by comparing demographic and personality data collected over Facebook with data collected through a standalone website, and data collected from college undergraduates at two universities. Results indicate that statistically significant differences exist between Facebook data and the comparison data-sets, but since 80% of analyses exhibited partial η2 < .05, such differences are small or practically nonsignificant in magnitude. We conclude that Facebook is a viable research platform, and that recruiting Facebook users for research purposes is a promising avenue that offers numerous advantages over traditional samples.

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Early Evaluation of the MAMAACT Trial

Case Medical Research ◽

10.31525/ct1-nct04261400 ◽

2020 ◽

Author(s):

Keyword(s):

Early Evaluation

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NHLBI Research Participant Recruitment Registry

Case Medical Research ◽

10.31525/ct1-nct04253769 ◽

2020 ◽

Author(s):

Keyword(s):

Research Participant ◽

Participant Recruitment

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PREP — The Preoperative Risk Education Package: an online educational resource for primary care clinicians to encourage community based prehabilitation prior to major surgery

British Journal of General Practice ◽

10.3399/bjgp18x697277 ◽

2018 ◽

Vol 68 (suppl 1) ◽

pp. bjgp18X697277

Author(s):

James Durrand ◽

F McHardy ◽

E Land ◽

Z Llewellyn ◽

C Norman ◽

...

Keyword(s):

Risk Factors ◽

Primary Care ◽

Perioperative Risk ◽

Perioperative Outcomes ◽

Major Surgery ◽

Educational Resource ◽

Major Step ◽

Early Evaluation ◽

Risk Education ◽

Primary Care Clinicians

BackgroundPrehabilitation prior to major surgery mandates cross-sector working. Utilising the preoperative window from referral requires clinician engagement. Awareness of perioperative risk factors is crucial. A national survey uncovered gaps in knowledge and understanding.AimCreate an open-access, online educational resource for primary care clinicians.MethodOur multidisciplinary team developed a focused CPD resource targeting lifestyle factors and chronic health conditions influencing perioperative risk (www.prepwell.co.uk).ResultsPREP highlights seven risk factors influencing perioperative risk: Smoking, alcohol, inactivity, anaemia, cognitive impairment, frailty and low BMI. A case study frames each factor alongside perioperative impact and prehabilitation strategies.ConclusionPREP is the first educational resource of its type. Early evaluation through local clinicians, the RCGP and RCOA has resulted in very positive feedback. We are working with Royal College representatives to gain formal endorsement and facilitate wider scale rollout, a major step towards raised clinician awareness and enhanced collaboration for improved perioperative outcomes.

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Active versus passive parental consent for improving participant recruitment and outcomes in studies targeting children

Cochrane Database of Systematic Reviews ◽

10.1002/14651858.mr000037 ◽

2012 ◽

Cited By ~ 2

Author(s):

Naomi Priest ◽

Rony Duncan ◽

Marie B H Yap ◽

Gerry Redmond ◽

Andrew Anderson ◽

...

Keyword(s):

Parental Consent ◽

Participant Recruitment

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Cardiotoxic effects and myocardial injury: the search for a more precise definition of drug cardiotoxicity

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2020-0566 ◽

2021 ◽

Vol 59 (1) ◽

pp. 51-57

Author(s):

Daniela Maria Cardinale ◽

Martina Zaninotto ◽

Carlo Maria Cipolla ◽

Claudio Passino ◽

Mario Plebani ◽

...

Keyword(s):

Early Detection ◽

Myocardial Injury ◽

Randomized Clinical Trials ◽

Imaging Techniques ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Cardiac Imaging Techniques ◽

Ventricular Ejection Fraction ◽

Early Evaluation ◽

Definition Of

AbstractDrug-induced cardiotoxicity is a major clinical problem; cardiotoxic drugs may induce both cardiac dysfunction and myocardial injury. Several recent studies reported that cardiac troponins measured with high-sensitivity methods (hs-cTn) can enable the early detection of myocardial injury related to chemotherapy or abuse of drugs that are potentially cardiotoxic. Several authors have some concerns about the standard definition of cardiotoxicity, in particular, regarding the early evaluation of chemotherapy cardiotoxicity in cancer patients. Several recent studies using the hs-cTn assay indicate that myocardial injury may precede by some months or years the diagnosis of heart failure (HF) based on the evaluation of left ventricular ejection fraction (LVEF). Accordingly, hs-cTn assay should considered to be a reliable laboratory test for the early detection of asymptomatic or subclinical cardiotoxic damage in patients undergoing cancer chemotherapy. In accordance with the Fourth Universal Definition of Myocardial Infarction and also taking into account the recent experimental and clinical evidences, the definition of drug-cardiotoxicity should be updated considering the early evaluation of myocardial injury by means of hs-cTn assay. It is conceivable that the combined use of hs-cTn assay and cardiac imaging techniques for the evaluation of cardiotoxicity will significantly increase both diagnostic sensitivity and specificity, and also better prevent chemotherapy-related left ventricular (LV) dysfunction and other adverse cardiac events. However, large randomized clinical trials are needed to evaluate the cost/benefit ratio of standardized protocols for the early detection of cardiotoxicity using hs-cTn assay in patients receiving chemotherapy for malignant diseases.

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