scholarly journals Contrast echocardiography: from left ventricular opacification to myocardial perfusion. Are the promises to be realised?

Heart ◽  
2003 ◽  
Vol 89 (12) ◽  
pp. 1389-1390 ◽  
Author(s):  
M J Monaghan
Keyword(s):  
Myocardial Perfusion ◽  
Contrast Echocardiography ◽  
Left Ventricular

scholarly journals Myocardial contrast echocardiography in the diagnosis of a left ventricular hemangioma

2016 ◽  
Vol 10 (2) ◽  
pp. 151
Author(s):  
Kyriacos Papadopoulos ◽  
Constantinos Makrides
Keyword(s):  
Myocardial Perfusion ◽  
Transthoracic Echocardiography ◽  
Contrast Echocardiography ◽  
Left Ventricular ◽  
Cardiac Mass ◽  
Cardiac Tumors ◽  
Final Report ◽  
Imaging Tool ◽  
Hypervascular Tumor ◽  
Primary Cardiac Tumors

Myocardial perfusion contrast echocardiography is an imaging tool for the assessment of myocardial microcirculation. It can also be used for the evaluation of the relative perfusion of a cardiac mass. Cardiac hemangiomas are rare tumors, accounting for only 2.8% of all benign primary cardiac tumors. We report a case of a 17-year-old man with a left ventricular hemangioma detected with transthoracic echocardiography. Myocardial perfusion contrast echocardiography was used to evaluate the vascularity of the cardiac mass. Using this technique malignant and hypervascular (<em>e.g</em>., hemangioma) tumors display persistence of contrast enhancement compared to the surrounding myocardium. The mass was successfully removed and the final report from pathology showed that the left ventricular mass was a hemangioma, a hypervascular tumor

scholarly journals Assessment of no-reflow phenomenon by myocardial contrast echocardiography in patients with acute myocardial infarction with ST-segment elevation

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
D Krinochkin ◽  
I Bessonov ◽  
E Yaroslavskaya ◽  
V Kuznetsov
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Myocardial Perfusion ◽  
Contrast Echocardiography ◽  
Left Ventricular ◽  
Myocardial Contrast Echocardiography ◽  
St Segment Elevation ◽  
No Reflow ◽  
St Segment ◽  
No Reflow Phenomenon

Abstract Funding Acknowledgements Type of funding sources: None. Background The noninvasive assessment of myocardial perfusion by echo contrast agents in patients with acute myocardial infarction with ST-segment elevation (STEMI) after successful revascularization is becoming a relevant clinical reality. Perfusion imaging techniques with myocardial contrast echocardiography (MCE) remains the least studied and most promising ultrasound technology for the diagnosis of no-reflow phenomenon. Purpose To study the echocardiographic and angiographic characteristics of the no-reflow phenomenon detected by MCE in patients with STEMI. Methods The study included 43 patients aged from 40 to 82 years in acute stage of myocardial infarction. Patients were divided into two groups: 32 patients characterized by sufficient myocardial reperfusion after revascularization according to MCE results and 11 patients were with the impaired perfusion. Results The patients with impaired perfusion demonstrated a greater size of the left ventricular (LV) asynergy (40.1 ± 2.2% vs 27.4 ± 8.5%, p &lt; 0.001). LV dilatation (LV end-systolic volume 67.3 ± 20.3 ml vs 51.8 ± 17.2 ml, p = 0.015), impaired LV ejection fraction (39.5 ± 3.4% vs 47.2 ± 4.9%, p &lt; 0.001), and significant mitral regurgitation (45.5% vs 3.1%, p = 0.011) with a decrease in DP/DT (979.9 ± 363.4 mmHg/s vs 1565.7 ± 502.8 mmHg/s, p &lt; 0.001) was more often detected in this group. In more than a quarter of these patients, coronary angiography showed no perfusion disorders after revascularization. In the group with impaired perfusion by MCE, the single-vascular lesions (46.9% vs 9.1%, p = 0.033), the lesions of the anterior interventricular artery (90.9% vs 40.6%, p = 0.004), and acute occlusion (100% vs 68.8%, p = 0.043) were more often determined. Conclusion According to the results of MCE, the echo signs of LV dysfunction were more pronounced after successful revascularization in patients with STEMI and myocardial perfusion disorders. The SYNTAX score was twice higher in these patients compared to the patients with recovered perfusion. In addition, no-reflow phenomenon by MCE was observed in the most patients with anterior interventricular artery lesion.

Echocardiographic determination of risk area size in a murine model of myocardial ischemia

1999 ◽  
Vol 277 (3) ◽  
pp. H986-H992 ◽  
Author(s):  
M. Scherrer-Crosbie ◽  
W. Steudel ◽  
R. Ullrich ◽  
P. R. Hunziker ◽  
N. Liel-Cohen ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Evans Blue ◽  
Perfusion Defect ◽  
Contrast Echocardiography ◽  
Anterior Wall ◽  
Left Ventricular ◽  
Experimental Myocardial Infarction ◽  
Blue Staining ◽  
Risk Area ◽  
Before And After

Genetically altered mice are useful to understand cardiac physiology. Myocardial contrast echocardiography (MCE) assesses myocardial perfusion in humans. We hypothesized it could evaluate murine myocardial perfusion before and after acute coronary ligation. MCE was performed before and after this experimental myocardial infarction (MI) in anesthetized mice by intravenous injection of contrast microbubbles and transthoracic echo imaging. Time-video intensity curves were obtained for the anterior, lateral, and septal myocardial walls. After MI, MCE defects were compared with the area of no perfusion measured by Evans blue staining. In healthy animals, intramyocardial contrast was visualized in all the cardiac walls. The anterior wall had a higher baseline video intensity (53 ± 17 arbitrary units) than the lateral (34 ± 13) and septal (27 ± 13) walls ( P < 0.001) and a lower increase in video intensity after contrast injection [50 ± 17 vs. 60 ± 24 (lateral) and 65 ± 29 (septum), P < 0.01]. After MI, left ventricular (LV) dimensions were enlarged, and the shortening fraction was decreased. A perfusion defect was imaged with MCE in every mouse, with a correlation between MCE perfusion defect size (35 ± 13%) and the nonperfused area by Evans blue (37 ± 16%, y = 0.77 x + 6.1, r = 0.93, P < 0.001). Transthoracic MCE is feasible in the mouse and can accurately detect coronary occlusions and quantitate nonperfused myocardium.

scholarly journals Contrast Echocardiography with a Quantitative Assessment of Myocardial Perfusion in Patients with Previous Q-Wave Myocardial Infarction

Kardiologiia ◽  
2020 ◽  
Vol 60 (2) ◽  
pp. 17-23
Author(s):  
I. N. Umnov ◽  
A. L. Bobrov ◽  
M. N. Alekhin
Keyword(s):  
Myocardial Infarction ◽  
Myocardial Perfusion ◽  
Cardiac Cycle ◽  
High Efficiency ◽  
Contrast Echocardiography ◽  
Ultrasound Contrast Agent ◽  
Left Ventricular ◽  
Myocardial Segment ◽  
Ultrasound Signal ◽  
Q Wave

Objective. To assess possibilities of contrast echocardiography with quantitative evaluation of myocardial perfusion in patients with previous Q-wave myocardial infarction.Materials and Methods. We examined 15 men (42-72 years) with coronary artery disease and previous myocardial infarction, and pathological Q-wave in 2 or more ECG leads. Quantification of left ventricular (LV) myocardial perfusion was performed by calculating of the ultrasound signal tissue intensity from the LV myocardial segments during intravenous administration of the ultrasound contrast agent (SonoVue). The Tissue intensive curve (TIC) analysis was done in the end-diastolic period before and on the fourth cardiac cycle after applying the "flash". Changes in the intensity of myocardial perfusion (A4, dB) was estimated as the difference between the intensity values of the ultrasound signal in the myocardial segment during the period of filling the contrast bubbles on 4-th cardiac cycle and before applying the «flash». Measurements were performed in 16 segments of the LV. A contrast cardiac magnetic resonance imaging (contrast MRI) was performed in order to verify the LV scar. Fibrotic changes of 50% of myocardial wall or more were considered as signs of post-infarction scar.Results. The dynamics of perfusion and scar presence in 240 myocardial segments were evaluated. The median A4 was 1 dB (range, -20 to 10 dB). MRI revealed 82 of 240 segments with the large-focal scar. The effectiveness of the diagnostic test (quantitative contrast perfusion echocardiography with A4 assessment) to detect myocardial scar was investigated. ROC curve analysis showed good model quality, AUC=0,787 (0,730-0,837); sensitivity 82.9%; specificity 75.3%; p<0.01. The cut-off point for A4 was -1.Conclusion. A new approach to quantitative contrast assessment of perfusion allows to identify perfusion disorders with high efficiency in patients with previous Q-wave myocardial infarction.

Contrast echocardiography

2011 ◽  
Author(s):  
L. Galiuto ◽  
R. Senior ◽  
H. Becher
Keyword(s):  
Myocardial Perfusion ◽  
Ejection Fraction ◽  
Imaging Modality ◽  
Contrast Echocardiography ◽  
Ultrasound Contrast Agent ◽  
Poor Quality ◽  
Left Ventricular ◽  
Left Ventricular Aneurysm ◽  
Endocardial Border ◽  
Echocardiographic Images

Contrast echocardiography is a non-invasive, well tolerated echocardiographic technique which employs ultrasound contrast agent in order to improve the quality of echocardiographic images, by enhancing blood flow signal.Clinical usefulness of this echocardiographic imaging modality resides in the possibility of providing better acoustic signal in cases of poor quality images, with additional important information related to assessment of myocardial perfusion. Indeed, about one-third of echocardiographic images are affected by poor quality due to high acoustic impedance of the chest wall of the patients secondary to obesity or pulmonary diseases, not allowing detection of left ventricular endocardial border. Moreover, in patients with low ejection fraction and apical left ventricular aneurysm, intraventricular thrombus could be undetectable with standard echocardiography. Furthermore, coronary microcirculation cannot be assessed by standard echocardiography. Contrast echocardiography can be performed in all such conditions to improve diagnostic power of echocardiography.The adjunctive role of contrast echocardiography is well defined in both rest and stress echocardiography in order to detect the endocardial border and intraventricular thrombi, to accurately measure ejection fraction, wall motion, and to assess myocardial perfusion.The purpose of this chapter is to explain basic principles, feasibility, safety, major clinical applications, current indications, and further developments of contrast echocardiography.

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