Echocardiographic determination of risk area size in a murine model of myocardial ischemia

1999 ◽  
Vol 277 (3) ◽  
pp. H986-H992 ◽  
Author(s):  
M. Scherrer-Crosbie ◽  
W. Steudel ◽  
R. Ullrich ◽  
P. R. Hunziker ◽  
N. Liel-Cohen ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Evans Blue ◽  
Perfusion Defect ◽  
Contrast Echocardiography ◽  
Anterior Wall ◽  
Left Ventricular ◽  
Experimental Myocardial Infarction ◽  
Blue Staining ◽  
Risk Area ◽  
Before And After

Genetically altered mice are useful to understand cardiac physiology. Myocardial contrast echocardiography (MCE) assesses myocardial perfusion in humans. We hypothesized it could evaluate murine myocardial perfusion before and after acute coronary ligation. MCE was performed before and after this experimental myocardial infarction (MI) in anesthetized mice by intravenous injection of contrast microbubbles and transthoracic echo imaging. Time-video intensity curves were obtained for the anterior, lateral, and septal myocardial walls. After MI, MCE defects were compared with the area of no perfusion measured by Evans blue staining. In healthy animals, intramyocardial contrast was visualized in all the cardiac walls. The anterior wall had a higher baseline video intensity (53 ± 17 arbitrary units) than the lateral (34 ± 13) and septal (27 ± 13) walls ( P < 0.001) and a lower increase in video intensity after contrast injection [50 ± 17 vs. 60 ± 24 (lateral) and 65 ± 29 (septum), P < 0.01]. After MI, left ventricular (LV) dimensions were enlarged, and the shortening fraction was decreased. A perfusion defect was imaged with MCE in every mouse, with a correlation between MCE perfusion defect size (35 ± 13%) and the nonperfused area by Evans blue (37 ± 16%, y = 0.77 x + 6.1, r = 0.93, P < 0.001). Transthoracic MCE is feasible in the mouse and can accurately detect coronary occlusions and quantitate nonperfused myocardium.

Abstract P35: Real-time Myocardial Contrast Echocardiography in Rat: Infusion vs. Bolus Administration

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Hai Li Su ◽  
Yun Qiu Qian ◽  
Zhang Rui Wei ◽  
Jian Guo He ◽  
Guo Quan Li ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Real Time ◽  
Evans Blue ◽  
Signal Intensity ◽  
Perfusion Defect ◽  
Ex Vivo ◽  
Contrast Echocardiography ◽  
Myocardial Contrast Echocardiography ◽  
Blue Staining ◽  
Bolus Administration

AIM: To compare the feasibility of real-time myocardial contrast echocardiography (RTMCE) in rats with infusion and bolus administration of BR1. Methods: RTMCE was performed in 12 Sprague-Dawley rats using B-mode RTMCE following the BR1 infusion or bolus injection. The myocardium signal intensity (SI) was plotted against time and was fitted to exponential functions. The plateau SI (A) and rate of SI increase (â) for the infusion study and peak signal intensity (PSI) for the bolus study were obtained. 99m Tc-Sestamibi and Evans blue were used to assess myocardial blood perfusion and to calculate the myocardium perfusion defect area ex vivo . Results: High-quality RTMCE images were successfully obtained using each method. At baseline, all LV segments showed even contrast distribution (Figure A ). Following left anterior descending (LAD) aorta ligation, significant perfusion defect was observed in LAD beds (Figure B , arrows) with a significantly decreased A*â and PSI values compared to LCx beds (Infusion: A* â LAD : 5.42 ± 1.57dB, A* â LCx : 46.52 ± 5.32dB, p± 0.05; Bolus: PSI LAD : 2.11 ± 0.67dB, PSI LCx : 20.68 ± 0.72 dB, p<0.05), which was consistent with 99m Tc-Sestamibi distribution findings. Myocardial perfusion defect areas assessed by both methods showed no differences and showed good correlation with Evans blue staining. ED frames were more favorable for imaging analysis. Conclusions: Both infusion and bolus administration of the contrast agent combined with RTMCE technique can provide a reliable and non-invasive approaches for myocardial perfusion assessment in rats, and the infusion method was more suitable for quantitative analysis of myocardial blood flow.

Abstract 6116: Assessment of Global and Regional Left Ventricular Twist in Patients with Anterior Wall Myocardial Infarction Before and After Revascularization by 2-D Speckle Tracking Imaging

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Mingxing Xie ◽  
Wei Han ◽  
Xinfang Wang ◽  
Minjuan Zheng ◽  
Shuping Ge
Keyword(s):  
Myocardial Infarction ◽  
Speckle Tracking ◽  
Anterior Wall ◽  
Left Ventricular ◽  
Control Group ◽  
Speckle Tracking Imaging ◽  
Time To Peak ◽  
Left Ventricular Twist ◽  
Before And After ◽  
Ventricular Twist

Background: Torsion of the left ventricle is related to myocardial architecture and contractility and is being evaluated as a sensitive marker of cardiac performance. New 2-D speckle tracking imaging (STI) may provide a powerful means of assessing LV torsion noninvasively. This study sought to evaluate the global and regional left ventricular twist in patients with anterior wall myocardial infarction (AMI) before and after revascularization by STI. Methods: A total of 50 subjects, including study group (n = 20) who underwent revascularization for AMI as well as 1 month after revascularization, and control group (n = 30) of normal individuals were studied using STI. LV twist was defined as apical rotation relative to the base. The peak LV twist, standard deviation of time to peak twist (Tw-SD) and maximal temporal difference of time to peak twist (Tw-diff) of 6 myocardial regions were measured. Results: Before revascularization, peak LV twist was significantly reduced while Tw-SD and Tw-diff significantly increased in patients with AMI as compared with normal control group ( P <0.001). One month after revascularization, these changes improved compared with pre- revascularization but remained diminished compared with normal controls (Table 1 ). There were significant correlations between LV peak twist and LVEF ( r =0.78, P <0.05), and LVEDD ( r =−0.63, P <0.05) in all subjects. Conclusion: LV twist measures significantly diminished and dys-synchronized in AMI patients prior to revascularization and improved after revascularization. STI measures correlate with EF and have the potential to quantify left ventricular global and segmental dysfunction in patients with AMI. Left ventricular regional and global peak twist, torsion and synchrony measures

scholarly journals Myocardial contrast echocardiography in the diagnosis of a left ventricular hemangioma

2016 ◽  
Vol 10 (2) ◽  
pp. 151
Author(s):  
Kyriacos Papadopoulos ◽  
Constantinos Makrides
Keyword(s):  
Myocardial Perfusion ◽  
Transthoracic Echocardiography ◽  
Contrast Echocardiography ◽  
Left Ventricular ◽  
Cardiac Mass ◽  
Cardiac Tumors ◽  
Final Report ◽  
Imaging Tool ◽  
Hypervascular Tumor ◽  
Primary Cardiac Tumors

Myocardial perfusion contrast echocardiography is an imaging tool for the assessment of myocardial microcirculation. It can also be used for the evaluation of the relative perfusion of a cardiac mass. Cardiac hemangiomas are rare tumors, accounting for only 2.8% of all benign primary cardiac tumors. We report a case of a 17-year-old man with a left ventricular hemangioma detected with transthoracic echocardiography. Myocardial perfusion contrast echocardiography was used to evaluate the vascularity of the cardiac mass. Using this technique malignant and hypervascular (<em>e.g</em>., hemangioma) tumors display persistence of contrast enhancement compared to the surrounding myocardium. The mass was successfully removed and the final report from pathology showed that the left ventricular mass was a hemangioma, a hypervascular tumor

scholarly journals Assessment of no-reflow phenomenon by myocardial contrast echocardiography in patients with acute myocardial infarction with ST-segment elevation

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
D Krinochkin ◽  
I Bessonov ◽  
E Yaroslavskaya ◽  
V Kuznetsov
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Myocardial Perfusion ◽  
Contrast Echocardiography ◽  
Left Ventricular ◽  
Myocardial Contrast Echocardiography ◽  
St Segment Elevation ◽  
No Reflow ◽  
St Segment ◽  
No Reflow Phenomenon

Abstract Funding Acknowledgements Type of funding sources: None. Background The noninvasive assessment of myocardial perfusion by echo contrast agents in patients with acute myocardial infarction with ST-segment elevation (STEMI) after successful revascularization is becoming a relevant clinical reality. Perfusion imaging techniques with myocardial contrast echocardiography (MCE) remains the least studied and most promising ultrasound technology for the diagnosis of no-reflow phenomenon. Purpose To study the echocardiographic and angiographic characteristics of the no-reflow phenomenon detected by MCE in patients with STEMI. Methods The study included 43 patients aged from 40 to 82 years in acute stage of myocardial infarction. Patients were divided into two groups: 32 patients characterized by sufficient myocardial reperfusion after revascularization according to MCE results and 11 patients were with the impaired perfusion. Results The patients with impaired perfusion demonstrated a greater size of the left ventricular (LV) asynergy (40.1 ± 2.2% vs 27.4 ± 8.5%, p &lt; 0.001). LV dilatation (LV end-systolic volume 67.3 ± 20.3 ml vs 51.8 ± 17.2 ml, p = 0.015), impaired LV ejection fraction (39.5 ± 3.4% vs 47.2 ± 4.9%, p &lt; 0.001), and significant mitral regurgitation (45.5% vs 3.1%, p = 0.011) with a decrease in DP/DT (979.9 ± 363.4 mmHg/s vs 1565.7 ± 502.8 mmHg/s, p &lt; 0.001) was more often detected in this group. In more than a quarter of these patients, coronary angiography showed no perfusion disorders after revascularization. In the group with impaired perfusion by MCE, the single-vascular lesions (46.9% vs 9.1%, p = 0.033), the lesions of the anterior interventricular artery (90.9% vs 40.6%, p = 0.004), and acute occlusion (100% vs 68.8%, p = 0.043) were more often determined. Conclusion According to the results of MCE, the echo signs of LV dysfunction were more pronounced after successful revascularization in patients with STEMI and myocardial perfusion disorders. The SYNTAX score was twice higher in these patients compared to the patients with recovered perfusion. In addition, no-reflow phenomenon by MCE was observed in the most patients with anterior interventricular artery lesion.

scholarly journals Experimental Myocardial Infarction Elicits Time-Dependent Patterns of Vascular Hypoxia in Peripheral Organs and in the Brain

2021 ◽  
Vol 7 ◽  
Author(s):  
Hélène David ◽  
Aurore Ughetto ◽  
Philippe Gaudard ◽  
Maëlle Plawecki ◽  
Nitchawat Paiyabhroma ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Tissue ◽  
Myocardial Strain ◽  
Anterior Wall ◽  
Left Ventricular ◽  
Experimental Myocardial Infarction ◽  
Diagnostic Modality ◽  
Peripheral Organs ◽  
The Brain

Aims: Microvascular alterations occurring after myocardial infarction (MI) may represent a risk factor for multi-organ failure. Here we used in vivo photoacoustic (PA) imaging to track and define the changes in vascular oxygen saturation (sO2) occurring over time after experimental MI in multiple peripheral organs and in the brain.Methods and Results: Experimental MI was obtained in BALB/c mice by permanent ligation of the left anterior descending artery. PA imaging (Vevo LAZR-X) allowed tracking mouse-specific sO2 kinetics in the cardiac left ventricular (LV) anterior wall, brain, kidney, and liver at 4 h, 1 day, and 7 days post-MI. Here we reported a correlation between LV sO2 and longitudinal anterior myocardial strain after MI (r = −0.44, p &lt; 0.0001, n = 96). Acute LV dysfunction was associated with global hypoxia, specifically a decrease in sO2 level in the brain (−5.9%), kidney (−6.4%), and liver (−7.3%) at 4 and 24 h post-MI. Concomitantly, a preliminary examination of capillary NG2DsRed pericytes indicated cell rarefication in the heart and kidney. While the cardiac tissue was persistently impacted, sO2 levels returned to pre-MI levels in the brain and in peripheral organs 7 days after MI.Conclusions: Collectively, our data indicate that experimental MI elicits precise trajectories of vascular hypoxia in peripheral organs and in the brain. PA imaging enabled the synchronous tracking of oxygenation in multiple organs and occurring post-MI, potentially enabling a translational diagnostic modality for the identification of vascular modifications in this disease setting.

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