Correction: xBritish Gynaecological Cancer Society/British Association of Gynaecological Pathology consensus for germline and tumor testing for BRCA1/2 variants in ovarian cancer in the United Kingdom

doi:10.1136/ijgc-2020-002112corr1

VI.—British Geological Photographs

Geological Magazine ◽

10.1017/s0016756800175041 ◽

1897 ◽

Vol 4 (1) ◽

pp. 31-37

Author(s):

W. W. Watts

Keyword(s):

United Kingdom ◽

British Association ◽

Large Collection ◽

The United Kingdom ◽

Private Control ◽

The Subject

A year ago, by the decision of the Council of the British Association, there was sent to the Museum of Practical Geology a large collection of photographs mainly taken with a view of illustrating, in the most permanent and unbiassed way at present possible, the features and phenomena of geological interest in the United Kingdom. The project of forming such a collectionoriginated with Mr. O. W. Jeffs in 1888, when he read a paperon the subject at the British Association at Bath, in which hepointed out the utility of such a collection and the necessity for forming it. When a committee was appointed in the followingyear he undertook the management of the work, and he has carriedit ou for seven years with indefatigable industry and scrupulou scare, only relinquishing it when the size of the collection beganto exceed the capabilities of private control, and when his own lackof leisure no longer permitted him to devote the requisite time andattention to its custody.

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2016 Laboratory guidelines for postvasectomy semen analysis: Association of Biomedical Andrologists, the British Andrology Society and the British Association of Urological Surgeons

Journal of Clinical Pathology ◽

10.1136/jclinpath-2016-203731 ◽

2016 ◽

Vol 69 (7) ◽

pp. 655-660 ◽

Cited By ~ 7

Author(s):

P Hancock ◽

B J Woodward ◽

A Muneer ◽

J C Kirkman-Brown

Keyword(s):

United Kingdom ◽

General Practitioner ◽

Semen Analysis ◽

Single Sample ◽

British Association ◽

Motile Sperm ◽

Iso 15189 ◽

The United Kingdom ◽

Two Samples ◽

The Uk

Post-vasectomy semen analysis (PVSA) is the procedure used to establish whether sperm are present in the semen following a vasectomy. PVSA is presently carried out by a wide variety of individuals, ranging from doctors and nurses in general practitioner (GP) surgeries to specialist scientists in andrology laboratories, with highly variable results.Key recommendations are that: (1) PVSA should take place a minimum of 12 weeks after surgery and after a minimum of 20 ejaculations. (2) Laboratories should routinely examine samples within 4 h of production if assessing for the presence of sperm. If non-motile sperm are observed, further samples must be examined within 1 h of production. (3) Assessment of a single sample is acceptable to confirm vasectomy success if all recommendations and laboratory methodology are met and no sperm are observed. Clearance can then be given. (4) The level for special clearance should be <100 000/mL non-motile sperm. Special clearance cannot be provided if any motile sperm are observed and should only be given after assessment of two samples in full accordance with the methods contained within these guidelines. Surgeons are responsible both preoperatively and postoperatively for the counselling of patients and their partners regarding complications and the possibility of late recanalisation after clearance. These 2016 guidelines replace the 2002 British Andrology Society (BAS) laboratory guidelines and should be regarded as definitive for the UK in the provision of a quality PVSA service, accredited to ISO 15189:2012, as overseen by the United Kingdom Accreditation Service (UKAS).

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Introduction

Paediatric Surgery ◽

10.1093/med/9780198798699.003.0001 ◽

2020 ◽

pp. 1-10

Keyword(s):

United Kingdom ◽

Surgical Care ◽

Second World War ◽

British Association ◽

Paediatric Surgery ◽

World War ◽

Surgical Specialty ◽

The United Kingdom ◽

Second World

Paediatric surgery is the surgical care of children from fetus to adolescent. It is a comparatively new surgical specialty, only formally recognized after the Second World War. This chapter provides a history and overview of the specialty, including the associations related to paediatric surgery, and biographies of famous surgeons who contributed to the field throughout their careers. The main organization in the United Kingdom is the British Association of Paediatric Surgeons (BAPS) founded in 1953 with Sir Denis Browne as the first president. Though based in London, it now has many international contacts and, through its conferences and symposia inside and outside the United Kingdom, is a leading educational provider in the specialty.

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Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening

Journal of Clinical Oncology ◽

10.1200/jco.2014.59.4945 ◽

2015 ◽

Vol 33 (18) ◽

pp. 2062-2071 ◽

Cited By ~ 116

Author(s):

Usha Menon ◽

Andy Ryan ◽

Jatinderpal Kalsi ◽

Aleksandra Gentry-Maharaj ◽

Anne Dawnay ◽

...

Keyword(s):

Ovarian Cancer ◽

United Kingdom ◽

Cancer Screening ◽

Ca 125 ◽

Ovarian Cancer Screening ◽

Collaborative Trial ◽

The United Kingdom ◽

Risk Algorithm ◽

The Impact ◽

Threshold Rule

Purpose Cancer screening strategies have commonly adopted single-biomarker thresholds to identify abnormality. We investigated the impact of serial biomarker change interpreted through a risk algorithm on cancer detection rates. Patients and Methods In the United Kingdom Collaborative Trial of Ovarian Cancer Screening, 46,237 women, age 50 years or older underwent incidence screening by using the multimodal strategy (MMS) in which annual serum cancer antigen 125 (CA-125) was interpreted with the risk of ovarian cancer algorithm (ROCA). Women were triaged by the ROCA: normal risk, returned to annual screening; intermediate risk, repeat CA-125; and elevated risk, repeat CA-125 and transvaginal ultrasound. Women with persistently increased risk were clinically evaluated. All participants were followed through national cancer and/or death registries. Performance characteristics of a single-threshold rule and the ROCA were compared by using receiver operating characteristic curves. Results After 296,911 women-years of annual incidence screening, 640 women underwent surgery. Of those, 133 had primary invasive epithelial ovarian or tubal cancers (iEOCs). In all, 22 interval iEOCs occurred within 1 year of screening, of which one was detected by ROCA but was managed conservatively after clinical assessment. The sensitivity and specificity of MMS for detection of iEOCs were 85.8% (95% CI, 79.3% to 90.9%) and 99.8% (95% CI, 99.8% to 99.8%), respectively, with 4.8 surgeries per iEOC. ROCA alone detected 87.1% (135 of 155) of the iEOCs. Using fixed CA-125 cutoffs at the last annual screen of more than 35, more than 30, and more than 22 U/mL would have identified 41.3% (64 of 155), 48.4% (75 of 155), and 66.5% (103 of 155), respectively. The area under the curve for ROCA (0.915) was significantly (P = .0027) higher than that for a single-threshold rule (0.869). Conclusion Screening by using ROCA doubled the number of screen-detected iEOCs compared with a fixed cutoff. In the context of cancer screening, reliance on predefined single-threshold rules may result in biomarkers of value being discarded.

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How to Improve Training in Bowel Surgery for Gynecological Oncologists—Experience From a Single Center in the United Kingdom

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e318220fcec ◽

2011 ◽

Vol 21 (9) ◽

pp. 1692-1694 ◽

Cited By ~ 2

Author(s):

Nikolaos Burbos ◽

Mazen Abu-Freij ◽

Sandeep Kapur ◽

Simon G. Crocker ◽

Timothy J. Duncan ◽

...

Keyword(s):

Ovarian Cancer ◽

United Kingdom ◽

Gastrointestinal Surgery ◽

Stage Iii ◽

Gynecological Oncology ◽

Bowel Surgery ◽

The United Kingdom ◽

Entire Duration ◽

Fellowship Programs ◽

Oncology Center

IntroductionThere is now a growing realization of the lack of experience of gynecological oncology trainees in gastrointestinal surgery. Advanced fellowship programs in gastrointestinal surgery have been suggested as a potential solution to this problem.Patients and MethodsWe present data relating to gastrointestinal procedures performed by the gynecological oncology trainee during a fellowship program over a 3-year period in a single gynecological oncology center in the United Kingdom.ResultsOver a 36-month period, 369 cases of invasive ovarian cancer were diagnosed in our institute, of which 278 (75.3%) were stage III/IV disease. Bowel surgery was performed in 86 patients (30.9%) with stage III/IV ovarian cancer. A total of 121 gastrointestinal procedures were performed during the study period, as some patients had more than one procedure. We present the procedures the gynecological oncology fellow performed and assisted during this period.DiscussionTo improve competencies in performing bowel surgery among gynecological oncology trainees, we suggest sustained exposure in bowel surgery over the entire duration of the training program.

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Audit of transvaginal sonography of normal postmenopausal ovaries by sonographers from the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

F1000Research ◽

10.12688/f1000research.15663.1 ◽

2018 ◽

Vol 7 ◽

pp. 1241

Author(s):

Will Stott ◽

Aleksandra Gentry-Maharaj ◽

Andy Ryan ◽

Nazar Amso ◽

Mourad Seif ◽

...

Keyword(s):

Ovarian Cancer ◽

United Kingdom ◽

Cancer Screening ◽

Transvaginal Ultrasound ◽

Probit Model ◽

Transvaginal Sonography ◽

Ovarian Cancer Screening ◽

Subsequent Increase ◽

Collaborative Trial ◽

The United Kingdom

Background: We report on a unique audit of seven sonographers self-reporting high visualization rates of normal postmenopausal ovaries in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). This audit was ordered by the trial’s Ultrasound Management Subcommittee after an initiative taken in 2008 to improve the quality of scanning and the subsequent increase in the number of sonographers claiming very high ovary visualisation rates. Methods: Seven sonographers reporting high rates (>89%) of visualizing normal postmenopausal ovaries in examinations performed between 1st January and 31st December 2008 were identified. Eight experts in gynaecological scanning reviewed a random selection of exams performed by these sonographers and assessed whether visualization of both ovaries could be confirmed (cVR-Both) in the examinations. A random effects bivariate probit model was fitted to analyse the results. Results: The eight experts reviewed images from 357 examinations performed on 349 postmenopausal women (mean age 60.0 years, range 50.2-73.3) by the seven sonographers. The mean cVR-Both obtained from the model for these sonographers was 67.2% with a range of 47.6-86.5% (95%CI 63.9-70.5%). The range of cVR-Both between the experts was 47.3-88.3% and the intra-class correlation coefficient (ICC) for left and right ovary confirmation was 0.39. Conclusions: The audit suggests that self-reported visualization of postmenopausal ovaries is unreliable, as visualisation of both ovaries could not be confirmed in almost a third of examinations. The agreement for visualization of both ovaries based on review of a static image between experts and sonographers and between expert reviewers alone was only moderate. Further research is needed to develop reliable Quality Control metrics for transvaginal ultrasound.

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