Comparison of the diagnostic value of serum pancreatic isoamylase and immunoreactive trypsin measurement in patients with cystic fibrosis.

A survey for submaxillary enlargement was carried out in 106 children with cystic fibrosis and 300 normal children. Submaxillary enlargement was found in 2% of the normal children and 92% of the children with cystic fibrosis. Chronic enlargement of the submaxillary glands is one of the clinical findings frequently present in children with cystic fibrosis, and it may also have diagnostic value. Cystic fibrosis must be considered as an important cause of chronic enlargement of the submaxillary glands in the pediatric age group.

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Cystic fibrosis--its biochemical detection.

Clinical Chemistry ◽

10.1093/clinchem/29.12.2011 ◽

1983 ◽

Vol 29 (12) ◽

pp. 2011-2018 ◽

Cited By ~ 8

Author(s):

A F Heeley ◽

D Watson

Keyword(s):

Cystic Fibrosis ◽

Filter Paper ◽

Neonatal Screening ◽

Duodenal Juice ◽

Heterozygous State ◽

Intestinal Malabsorption ◽

Pancreatic Lesion ◽

Pancreatic Dysfunction ◽

Pancreatic Isoamylase ◽

Biochemical Detection

Abstract We examine critically the biochemical methods capable of detecting and monitoring the end-organ disease processes in patients with cystic fibrosis. Although the diagnosis of cystic fibrosis is never justified on the basis of the sweat salt test alone, the original filter-paper technic (Gibson-Cooke, Pediatrics 23:545-549, 1959) for determining Na+ and Cl- concentrations in sweat remains the most discriminating method. We discuss the contributions for neonatal screening of the so-called cystic fibrosis protein, associated decreased enzymic activities in the homo- and heterozygous state, and immunoreactive trypsin. Because evidence of either intestinal malabsorption or a pancreatic lesion must be sought, we review the use and interpretation of some tests of pancreatic dysfunction (meconium albumin, duodenal juice components, serum pancreatic isoamylase, and trypsinogen), both in establishing and in confirming the diagnosis of cystic fibrosis.

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Levels and Molecular Forms of Immunoreactive Trypsin and Chymotrypsin in Amniotic Fluids from Normal and Cystic Fibrosis Fetus

Journal of Pediatric Gastroenterology and Nutrition ◽

10.1097/00005176-199202000-00014 ◽

1992 ◽

Vol 14 (2) ◽

pp. 198-203 ◽

Cited By ~ 7

Author(s):

J. Carrère ◽

F. Muller ◽

A. Boué ◽

O. Guy-Crotte ◽

C. Figarella

Keyword(s):

Cystic Fibrosis ◽

Molecular Forms ◽

Immunoreactive Trypsin

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SERUM-IMMUNOREACTIVE-TRYPSIN CONCENTRATIONS IN CYSTIC FIBROSIS

The Lancet ◽

10.1016/s0140-6736(79)92783-1 ◽

1979 ◽

Vol 313 (8124) ◽

pp. 1032 ◽

Cited By ~ 8

Author(s):

P. Dandona ◽

M. Hodson ◽

J. Bell ◽

L. Ramdial ◽

J.C. Batten

Keyword(s):

Cystic Fibrosis ◽

Immunoreactive Trypsin

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187 Diagnostic value of Pseudomonas aeruginosa antibodies in Cystic Fibrosis

Journal of Cystic Fibrosis ◽

10.1016/s1569-1993(06)80169-4 ◽

2006 ◽

Vol 5 ◽

pp. S43

Author(s):

E. Ratjen ◽

H. Walter ◽

M. Haug ◽

C. Meisner ◽

H. Grasemann ◽

...

Keyword(s):

Cystic Fibrosis ◽

Pseudomonas Aeruginosa ◽

Diagnostic Value

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Conclusions from a pilot immunoreactive trypsin newborn screen for cystic fibrosis.

Clinical Chemistry ◽

10.1093/clinchem/29.8.1559a ◽

1983 ◽

Vol 29 (8) ◽

pp. 1559-1560 ◽

Cited By ~ 1

Author(s):

L T Kirby ◽

A G Davidson ◽

D A Applegarth ◽

L T Wong ◽

D F Hardwick

Keyword(s):

Cystic Fibrosis ◽

Immunoreactive Trypsin ◽

Newborn Screen

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Diagnosis of cystic fibrosis-related glucose abnormalities: Can we shorten the standard oral glucose tolerance test?

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2013-0022 ◽

2013 ◽

Vol 38 (12) ◽

pp. 1254-1259 ◽

Cited By ~ 8

Author(s):

Adèle Coriati ◽

Belinda Elisha ◽

Sandrine Virassamynaik ◽

Maude Phaneuf ◽

Sophie Ziai ◽

...

Keyword(s):

Cystic Fibrosis ◽

Glucose Tolerance ◽

Oral Glucose Tolerance Test ◽

Glucose Tolerance Test ◽

Diagnostic Value ◽

Tolerance Test ◽

Oral Glucose ◽

Oral Glucose Tolerance ◽

Cross Sectional ◽

Diagnostic Values

Adult patients with cystic fibrosis (APCF) are at high risk of developing impaired glucose tolerance (IGT) and CF-related diabetes (CFRD) and thus an annual screening with a 2-h oral glucose tolerance test (OGTT) is recommended. This population would greatly benefit from a simplified and harmless alternative to the standard OGTT. Thus, we aimed to compare the diagnostic values of HbA1c and glycemias at interval time points during the 2-h OGTT for IGT and CFRD detection in APCF. To do so, we conducted a cross-sectional analysis of 194 APCF with normal fasting plasma glucose values (≤7.0 mmol·L−1) who underwent a 2-h OGTT. Receivers operating characteristic area under the curves (ROC-AUC) were analyzed to assess the diagnostic value of HbA1c and intermediate OGTT glycemias using 2-h OGTT glycemia as reference. For both IGT and CFRD diagnoses, ROC-AUC values obtained from glycemia at 90 min were significantly higher than HbA1c and remaining intermediate glycemias (p < 0.001). The best 90-min OGTT cut-off values for these diagnoses were >9.3 mmol·L−1 (IGT) and ≥11.5 mmol·L−1 (CFRD). A 90-min OGTT glycemia might be a simplified alternative to 2-h OGTT glycemia for earlier glucose tolerance abnormalities diagnosis in APCF. This finding should be confirmed in other APCF cohorts and its predictive value should be established prospectively.

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