OP09 Prescribing of Nicotine Replacement Therapy in and Around Pregnancy in the UK – A Population Based Study using Primary Care Data

IntroductionNicotine replacement therapy (NRT) has proven effective for smoking cessation in clinical trials, however it was found less effective in population-based studies, potentially due to inconsistent or incorrect use of NRT. The aim of this paper is to describe a systematic review protocol to evaluate level of adherence to NRT; the discrepancy of adherence to NRT in clinical and population-based studies and degree of association between level of adherence and success of smoking cessation.Methods and analysisLiterature search will use five databases (Medline, Scopus, Embase, CINAHL and PsycINFO). Studies will be appraised for methodological quality using National Institutes of Health Quality Assessment Tool. To reduce heterogeneity, we will analyse clinical trials and population-based studies separately; pooled analyses will be done among studies that used similar measurements. Heterogeneity of studies will be assessed by Higgins’ I2 statistical test. When studies are adequately homogeneous, results will be pooled using random-effects model with proportion and ORs with 95% CIs and p values for each outcome. We will explain sources of heterogeneity by subgroup analysis or sensitivity analysis. Funnel plots and Egger’s regression asymmetry test with p<0.05 will be used as a cut-off point to affirm presence of statistically significant publication bias. Statistical analyses will be carried out using Stata V.16 software. Only studies reporting a valid strategy to control for reverse causality will be included.DiscussionThis review will provide evidence to support the importance of adherence on rate of smoking cessation and level of adherence to NRT. The findings will be used to inform smoking cessation interventions, researchers and policymakers.Ethics and disseminationAs a systematic literature review, this protocol does not require ethics approval. Research outcomes will be presented at relevant conferences and findings will be published in a relevant peer-reviewed journal.PROSPERO registration numberCRD42020176749.

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P2-367 Variations in perinatal depression, anxiety and severe mental illnesses by maternal age and socioeconomic group: a population-based study in UK primary care data

Journal of Epidemiology & Community Health ◽

10.1136/jech.2011.142976k.98 ◽

2011 ◽

Vol 65 (Suppl 1) ◽

pp. A324-A324

Author(s):

L. Ban ◽

J. E. Gibson ◽

J. West ◽

L. J. Tata

Keyword(s):

Primary Care ◽

Maternal Age ◽

Perinatal Depression ◽

Population Based ◽

Mental Illnesses ◽

Socioeconomic Group ◽

Population Based Study ◽

Primary Care Data ◽

Group A

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Does smoking reduction make smokers happier? Evidence from a cross-sectional survey

The Journal of Smoking Cessation ◽

10.1017/jsc.2013.14 ◽

2013 ◽

Vol 9 (1) ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Emma Beard ◽

Jamie Brown ◽

Robert West

Keyword(s):

Life Satisfaction ◽

Harm Reduction ◽

Replacement Therapy ◽

Nicotine Replacement Therapy ◽

Clinical Excellence ◽

Smoking Reduction ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Nicotine Replacement ◽

The Uk

Objectives: Stopping smoking leads to greater happiness and life satisfaction. This raises the question as to whether harm reduction, i.e. smoking reduction (SR) and the use of Nicotine Replacement Therapy (NRT) for SR, might lead to a similar benefit. This is of importance, given that the National Institute of Clinical Excellence in the UK is due to release guidance on harm reduction in 2013.Design: Data were collected from 1,532 smokers involved in the Smoking Toolkit Study.Method: Participants were asked if they were cutting down and if they were using Nicotine Replacement Therapy (NRT). Smokers also rated happiness and life satisfaction.Results: There was no evidence of an association between SR or use of NRT for SR and either reported ‘happiness’ or ‘life satisfaction’. Nor was there an association between measures of ‘happiness’ or ‘life satisfaction’ and cigarette consumption.Conclusion: It appears that SR is not associated with mental health benefits. This suggests that complete cessation may be necessary for benefits to be incurred. Prospective studies are necessary to confirm these findings.

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