scholarly journals A high degree of chromosomal instability at 13q14 in cutaneous squamous cell carcinomas: indication for a role of a tumour suppressor gene other than Rb

2001 ◽  
Vol 54 (3) ◽  
pp. 165-169 ◽  
Author(s):  
D P O'Connor
Keyword(s):  
Squamous Cell ◽  
Chromosomal Instability ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Squamous Cell Carcinomas ◽  
Tumour Suppressor ◽  
High Degree

scholarly journals ROLE OF TUMOUR SUPPRESSOR GENE P53 IN TRIPLE NEGATIVE BREAST CANCER

2017 ◽  
Vol 5 (4.2) ◽  
pp. 4585-4589
Author(s):  
Priya S Patil ◽  
◽  
Jaydeep N Pol ◽  
Ashalata D Patil ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor

The role of the Wilms' tumour-suppressor protein WT1 in apoptosis

2008 ◽  
Vol 36 (4) ◽  
pp. 629-631 ◽  
Author(s):  
Jörg Hartkamp ◽  
Stefan G.E. Roberts
Keyword(s):  
Transcription Factor ◽  
Zinc Finger ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Wilms Tumour ◽  
Zinc Finger Transcription Factor ◽  
Tumour Suppressor Protein ◽  
Proliferation And Apoptosis

The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult cancer.

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