Optical coherence tomography evaluation of tissue prolapse after carotid artery stenting using closed cell design stents for unstable plaque

2017 ◽  
Vol 10 (3) ◽  
pp. 229-234 ◽  
Author(s):  
Kei Harada ◽  
Shogo Oshikata ◽  
Masahito Kajihara
Keyword(s):  
Optical Coherence Tomography ◽  
Carotid Artery ◽  
Carotid Artery Stenting ◽  
Cell Design ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Closed Cell ◽  
Procedural Complications ◽  
Oct Imaging ◽  
Unstable Plaques

Background and purposeDuring carotid artery stenting (CAS) with the use of closed cell design stents for unstable plaques, tissue prolapse between stent struts was evaluated by optical coherence tomography (OCT).Methods14 carotid stenosis lesions diagnosed as unstable plaques by MRI were evaluated by OCT imaging during CAS using closed cell stents. Cross sectional OCT images within the stented segment were evaluated at 1 mm intervals. The slice rate for the presence of tissue prolapse between the struts was calculated.ResultsNo intra-procedural complications occurred. After single stent placement, plaque prolapse was observed in all cases. Slices with any and >500 µm tissue prolapse were seen in 30% and 7.8% of cases, respectively. In 5 of 7 lesions with tissue prolapse >500 µm, additional stents were overlapped. In cases with overlapping stents, slices with any tissue prolapse were significantly decreased from 26% to 16% (p=0.008); in particular, the occurrence of tissue prolapse >500 µm was significantly decreased from 15% to 2.3% (p<0.001). In one case of >500 µm tissue prolapse without an overlapping stent, delayed embolization due to an in-stent thrombus occurred 9 months after the procedure.ConclusionsOCT during CAS using closed cell stent for unstable plaques frequently revealed tissue prolapse between struts. Placement of overlapping stents significantly reduced tissue prolapse, particularly tissue prolapse >500 µm. However, closed cell stents used for unstable plaques may not solve the problem of tissue prolapse.

Ex Vivo assessment of competent strut coverage after coronary stenting by optical coherence tomography

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R Bhoite ◽  
H Jinnouchi ◽  
F Otsuka ◽  
Y Sato ◽  
A Sakamoto ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Predictive Value ◽  
Ex Vivo ◽  
High Sensitivity ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Neointimal Thickness ◽  
Stent Strut ◽  
Oct Imaging ◽  
Definition Of

Abstract Background In many studies, struts coverage is defined as &gt;0 mm of tissue overlying the stent struts by optical coherence tomography (OCT). However, this definition has never been validated using histology as the “gold standard”. The present study sought to assess the appropriate cut-off value of neointimal thickness of stent strut coverage by OCT using histology. Methods OCT imaging was performed on 39 human coronary arteries with stents from 25 patients at autopsy. A total of 165 cross-sectional images from 46 stents were co-registered with histology. The optimal cut-off value of strut coverage by OCT was determined. Strut coverage by histology was defined as endothelial cells with at least underlying two layers of smooth muscle cells. Considering the resolution of OCT is 10–20 μm, 3 different cut-off values (i.e. at ≥20, ≥40, and ≥60 μm) were assessed. Results A total of 2235 struts were evaluated by histology. Eventually, 1216 struts which were well-matched struts were analyzed in this study. By histology, uncovered struts were observed in 160 struts and covered struts were observed in 1056 struts. The broadly used definition of OCT-coverage which does not consider neointimal thickness yielded a poor specificity of 37.5% and high sensitivity 100%. Of 3 cut-off values, the cut-off value of &gt;40 μm was more accurate as compared to &gt;20 and &gt;60 mm [sensitivity (99.3%), specificity (91.0%), positive predictive value (98.6%), and negative predictive value (95.6%)] Conclusion The most accurate cut-off value was ≥40 μm neointimal thickness by OCT in order to identify stent strut coverage validated by histology. Funding Acknowledgement Type of funding source: None

scholarly journals Optical coherence tomography as an adjunct during carotid artery stenting for carotid web

2019 ◽  
Vol 9 (6) ◽  
pp. 484-486 ◽  
Author(s):  
Christopher R. Pasarikovski ◽  
Joel Ramjist ◽  
Leodante da Costa ◽  
Victor X.D. Yang
Keyword(s):  
Optical Coherence Tomography ◽  
Carotid Artery ◽  
Carotid Artery Stenting ◽  
Optical Coherence

Optical Coherence Tomography as an Adjunct During Carotid Artery Stenting for Carotid Atherosclerotic Disease

2019 ◽  
Vol 30 (3) ◽  
pp. 503-509 ◽  
Author(s):  
Christopher R. Pasarikovski ◽  
Joel Ramjist ◽  
Leodante da Costa ◽  
Sandra E. Black ◽  
Jillian Cardinell ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Carotid Artery ◽  
Carotid Artery Stenting ◽  
Atherosclerotic Disease ◽  
Optical Coherence

scholarly journals Cooperative Three-View Imaging Optical Coherence Tomography for Intraoperative Vascular Evaluation

2018 ◽  
Vol 8 (9) ◽  
pp. 1551
Author(s):  
Shizhao Peng ◽  
Yuanzhen Jiang ◽  
Kailin Zhang ◽  
Chuanchao Wu ◽  
Danni Ai ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Mechanical Design ◽  
Optical Design ◽  
Flow Speed ◽  
Imaging Method ◽  
Outer Diameter ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Imaging Optical Coherence Tomography ◽  
Oct Imaging

Real-time intraoperative optical coherence tomography (OCT) imaging of blood vessels after anastomosis operation can provide important information the vessel, such as patency, flow speed, and thrombosis morphology. Due to the strong scattering and absorption effect of blood, normal OCT imaging suffers from the problem of incomplete cross-sectional view of the vessel under investigation when the diameter is large. In this work, we present a novel cooperative three-view imaging spectral domain optical coherence tomography system for intraoperative exposed vascular imaging. Two more side views (left view and right view) were realized through a customized sample arm optical design and corresponding mechanical design and fabrication, which could generate cross-sectional images from three circumferential view directions to achieve a larger synthetic field of view (FOV). For each view, the imaging depth was 6.7 mm (in air) and the lateral scanning range was designed to be 3 mm. Therefore, a shared synthetic rectangle FOV of 3 mm × 3 mm was achieved through cooperative three view scanning. This multi-view imaging method can meet the circumferential imaging demands of vessels with an outer diameter less than 3 mm. Both phantom tube and rat vessel imaging confirmed the increased system FOV performance. We believe the intraoperative application of this cooperative three-imaging optical coherence tomography for objective vascular anastomosis evaluation can benefit patient outcomes in the future.

scholarly journals Development of optical coherence tomography technique for clinical diagnostics and monitoring

2021 ◽  
Author(s):  
Marjan Razani
Keyword(s):  
Optical Coherence Tomography ◽  
Carotid Artery ◽  
Shear Wave ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Optical Coherence ◽  
Swept Source ◽  
Tissue Equivalent ◽  
Oct Imaging

This dissertation describes techniques that use Optical Coherence Tomography techniques developed for the detection of shear wave propagation in different phantoms, and the use of such waves to enhance the transport of nanoparticles in tissue equivalent phantoms. In the first study, we explored the potential of measuring shear wave propagation using optical co-herence elastography (OCE) in an inhomogeneous phantom and carotid artery samples based on a swept source optical coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs duration, applying acoustic radiation force (ARF) to inhomogeneous phantoms and carotid artery samples, syn-chronized with a swept-source OCT (SS-OCT) imaging system. The phantoms were com-posed of gelatin and titanium dioxide whereas the carotid artery samples were embedded in propagating shear waves in inhomogeneous tissue equivalent phantoms and carotid artery samples using the ARF of an ultrasound transducer, and measuring the shear wave speed and its associated properties in the different layers with OCT phase maps. In the second study, we present a technique to image the enhanced particle displacement generated using an acoustic radiation force (ARF) excitation source. A MEMS-VCSEL swept source Optical Coherence Tomography (SS-OCT) system with a center wavelength of 1310 nm, a bandwidth of 100nm, and an A-scan rate of 100 kHz was used to detect gold nanoparticle displacement. ARF was applied after the nanoparticles diffused into a collagen matrix (of different collagen concen-trations and for a tissue engineered MCF-7 breast cancer cell construct). Differential OCT speckle variance images with and without the ARF were used to estimate the particle dis-placement. The images were used to detect the microscopic enhancement of nanoparticle displacement generated by the ARF. Using this OCT imaging technique, the enhanced transport of particles though a collagen gel after using an ARF excitation was imaged and analysed.

scholarly journals Carotid artery stenting with optical coherence tomography

Neurology ◽  
2018 ◽  
Vol 90 (8) ◽  
pp. 384-385
Author(s):  
Naif M. Alotaibi ◽  
Francesca Sarzetto ◽  
Joel Ramjist ◽  
Victor X.D. Yang
Keyword(s):  
Optical Coherence Tomography ◽  
Carotid Artery ◽  
Carotid Artery Stenting ◽  
Optical Coherence

Optical coherence tomography guided cystoscopy in diagnosis and management of clinical bladder tumors

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 15518-15518
Author(s):  
C. S. Lee ◽  
M. Mishail ◽  
W. C. Waltzer ◽  
J. Liu ◽  
Z. Wang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Optical Coherence Tomography ◽  
High Resolution ◽  
Optical Coherence ◽  
Bladder Tumors ◽  
Cross Sectional ◽  
Bladder Urothelium ◽  
Cross Sectional Imaging ◽  
Sectional Imaging ◽  
Oct Imaging

15518 Background: Optical coherence tomography (OCT) is a novel tool that permits high-resolution cross-sectional imaging of bladder urothelium during cystoscopy. OCT delineates morphological features of the bladder urothelium, the lamina propria, and the muscularis layer based on their backscattering patterns. We hypothesize that application of microelectromechanical systems (MEMS) mirrors for OCT can improve cross-sectional image resolution of bladder lesions. We report preliminary results from our prospective non-randomized study using MEMS mirror OCT imaging during cystoscopy. Methods: Following our institutional IRB approval, a prospective correlative study was performed evaluating the role of cross-sectional OCT in diagnosis and treatment of bladder cancers. OCT cystoscopy was performed in thirty patients undergoing cystoscopy or transurethral resection for suspected bladder tumors. Any suspicious lesions or tumors seen on cystoscopy were either biopsied or resected as per standard of care. The primary endpoints were patient safety and the correlation between OCT images and histology. Results: Bladder cancer was identified in twenty five patients by pathological evaluation. Twenty four out of twenty five patients were correctly diagnosed with cross-sectional OCT imaging. Four out of five patients with benign lesions were correctly identified. There was one false positive and one false negative in our series. Overall sensitivity and specificity of cross-sectional OCT in diagnosing bladder cancer was 96 and 80%, respectively. There were no complications related to OCT cystoscopy. Axial and lateral resolutions were 10 and 12 microns, respectively. The field of view was measured at 4.5 mm with the depth of penetration measured to be 2 mm. Conclusions: OCT cystoscopy is a promising new tool in diagnosis of bladder cancer. Our preliminary data suggests OCT with MEMS mirrors resulted in high resolution images that may aid in the diagnosis of bladder cancer during cystoscopy. Application of OCT cross sectional imaging may have additional benefits: improved diagnosis, identification of surgical margins, and more complete resection of bladder tumors. No significant financial relationships to disclose.

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