OP IV – 5 Long-term air pollution and incidence of the metabolic syndrome in the population-based heinz nixdorf recall study

Objectives: Many reports demonstrate improvements in cardiovascular risk factors during GH replacement (rhGH) in adult GH deficiency (GHD). However, it remains to be determined to what extent these changes translate into a reduction of increased cardiovascular morbidity and mortality. The aim of this study was to evaluate the effects of long-term rhGH replacement on the prevalence of the metabolic syndrome (MS). Design, settings, main outcome measures: The MS was scored by the National Cholesterol Education Program-Adult Treatment Panel III definition in 50 consecutive GHD patients (45 ± 9 years of age), before and after 2 and 5 years of rhGH replacement, and the data of untreated patients were compared with the general population using data from a Dutch population-based study (n = 1062, 44 ± 8 years of age). Results: Hypertriglyceridaemia (46.0 vs 18.5%, P < 0.0001), hypertension (66.0 vs 35.5%, P < 0.0001) and abdominal obesity (38.0 vs 23.4%, P = 0.0178) were more prevalent in untreated patients when compared with controls, resulting in a higher prevalence of the MS in patients (38.0 vs 15.7%, P < 0.0001). During rhGH replacement at a mean dose of 0.5 ± 0.2 mg/day resulting in IGF-I concentrations in the normal age-adjusted reference range, mean high-density lipoprotein cholesterol level increased compared with baseline (P < 0.001). However, the prevalence of (components of) the MS did not change after 2 or 5 years of treatment with rhGH. Conclusion: In this study, the prevalence of the MS in patients with GHD is increased compared with healthy controls, irrespective of rhGH replacement.

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Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study

BMJ ◽

10.1136/bmj.38766.624097.1f ◽

2006 ◽

Vol 332 (7546) ◽

pp. 878-882 ◽

Cited By ~ 233

Author(s):

Johan Sundström ◽

Ulf Risérus ◽

Liisa Byberg ◽

Björn Zethelius ◽

Hans Lithell ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Cardiovascular Mortality ◽

Population Based ◽

Clinical Value ◽

The Metabolic Syndrome ◽

Term Prediction ◽

Long Term Prediction

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Effect of Bariatric Surgery on the Metabolic Syndrome: A Population-Based, Long-term Controlled Study

Mayo Clinic Proceedings ◽

10.4065/83.8.897 ◽

2008 ◽

Vol 83 (8) ◽

pp. 897-906 ◽

Cited By ~ 22

Author(s):

John A. Batsis ◽

Abel Romero-Corral ◽

Maria L. Collazo-Clavell ◽

Michael G. Sarr ◽

Virend K. Somers ◽

...

Keyword(s):

Bariatric Surgery ◽

Metabolic Syndrome ◽

Population Based ◽

Controlled Study ◽

The Metabolic Syndrome

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ENVINT-D-20-01309: Long-term exposure to air pollution, road traffic noise, residential greenness, and prevalent and incident metabolic syndrome: Results from the population-based KORA F4/FF4 cohort in Augsburg, Germany

Environment International ◽

10.1016/j.envint.2020.106364 ◽

2021 ◽

Vol 147 ◽

pp. 106364

Author(s):

Stephan Voss ◽

Alexandra Schneider ◽

Cornelia Huth ◽

Kathrin Wolf ◽

Iana Markevych ◽

...

Keyword(s):

Metabolic Syndrome ◽

Air Pollution ◽

Road Traffic ◽

Traffic Noise ◽

Population Based ◽

Road Traffic Noise ◽

D 20

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Long-Term Exposure to PM2.5 and Cognitive Decline: A Longitudinal Population-Based Study

Journal of Alzheimer s Disease ◽

10.3233/jad-200852 ◽

2021 ◽

pp. 1-9

Author(s):

Giulia Grande ◽

Jing Wu ◽

Petter L.S. Ljungman ◽

Massimo Stafoggia ◽

Tom Bellander ◽

...

Keyword(s):

Air Pollution ◽

Cognitive Decline ◽

Population Based ◽

Cerebrovascular Diseases ◽

Air Pollutant ◽

National Study ◽

Piecewise Regression ◽

Risk Increase ◽

Restricted Cubic Splines

Background: A growing but contrasting evidence relates air pollution to cognitive decline. The role of cerebrovascular diseases in amplifying this risk is unclear. Objectives: 1) Investigate the association between long-term exposure to air pollution and cognitive decline; 2) Test whether cerebrovascular diseases amplify this association. Methods: We examined 2,253 participants of the Swedish National study on Aging and Care in Kungsholmen (SNAC-K). One major air pollutant (particulate matter ≤2.5μm, PM2.5) was assessed yearly from 1990, using dispersion models for outdoor levels at residential addresses. The speed of cognitive decline (Mini-Mental State Examination, MMSE) was estimated as the rate of MMSE decline (linear mixed models) and further dichotomized into the upper (25%fastest cognitive decline), versus the three lower quartiles. The cognitive scores were used to calculate the odds of fast cognitive decline per levels of PM2.5 using regression models and considering linear and restricted cubic splines of 10 years exposure before the baseline. The potential modifier effect of cerebrovascular diseases was tested by adding an interaction term in the model. Results: We observed an inverted U-shape relationship between PM2.5 and cognitive decline. The multi-adjusted piecewise regression model showed an increased OR of fast cognitive decline of 81%(95%CI = 1.2–3.2) per interquartile range difference up to mean PM2.5 level (8.6μg/m3) for individuals older than 80. Above such level we observed no further risk increase (OR = 0.89;95%CI = 0.74–1.06). The presence of cerebrovascular diseases further increased such risk by 6%. Conclusion: Low to mean PM2.5 levels were associated with higher risk of accelerated cognitive decline. Cerebrovascular diseases further amplified such risk.

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Impact of short- and long-term exposure to air pollution on blood pressure: A two-decade population-based study in Tehran

International Journal of Hygiene and Environmental Health ◽

10.1016/j.ijheh.2021.113719 ◽

2021 ◽

Vol 234 ◽

pp. 113719

Author(s):

Alireza Khajavi ◽

Seyed Saeed Tamehri Zadeh ◽

Fereidoun Azizi ◽

Robert D. Brook ◽

Hengameh Abdi ◽

...

Keyword(s):

Blood Pressure ◽

Air Pollution ◽

Population Based ◽

Population Based Study ◽

Short And Long Term

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Prevalence of the metabolic syndrome in women with a previous diagnosis of polycystic ovary syndrome: long-term follow-up

Fertility and Sterility ◽

10.1016/j.fertnstert.2011.08.006 ◽

2011 ◽

Vol 96 (5) ◽

pp. 1271-1274 ◽

Cited By ~ 26

Author(s):

Miriam Hudecova ◽

Jan Holte ◽

Matts Olovsson ◽

Anders Larsson ◽

Christian Berne ◽

...

Keyword(s):

Metabolic Syndrome ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

The Metabolic Syndrome ◽

Previous Diagnosis ◽

Long Term Follow Up

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Serum IGF1, metabolic syndrome, and incident cardiovascular disease in older people: a population-based study

Acta Endocrinologica ◽

10.1530/eje-12-0784 ◽

2013 ◽

Vol 168 (3) ◽

pp. 393-401 ◽

Cited By ~ 28

Author(s):

Christa C van Bunderen ◽

Mirjam M Oosterwerff ◽

Natasja M van Schoor ◽

Dorly J H Deeg ◽

Paul Lips ◽

...

Keyword(s):

Metabolic Syndrome ◽

Older People ◽

Population Based ◽

Mortality Data ◽

The Metabolic Syndrome ◽

Longitudinal Aging Study Amsterdam ◽

Aging Study ◽

Definition Of ◽

Relationship Of ◽

The Relationship

ObjectiveHigh as well as low levels of IGF1 have been associated with cardiovascular diseases (CVD). The relationship of IGF1 with (components of) the metabolic syndrome could help to clarify this controversy. The aims of this study were: i) to investigate the association of IGF1 concentration with prevalent (components of) the metabolic syndrome; and ii) to examine the role of (components of) the metabolic syndrome in the relationship between IGF1 and incident CVD during 11 years of follow-up.MethodsData were used from the Longitudinal Aging Study Amsterdam, a cohort study in a representative sample of the Dutch older population (≥65 years). Data were available in 1258 subjects. Metabolic syndrome was determined using the definition of the US National Cholesterol Education Program Adult Treatment Panel III. CVD were ascertained by self-reports and mortality data.ResultsLevels of IGF1 in the fourth quintile were associated with prevalent metabolic syndrome compared with the lowest quintile (odds ratio: 1.59, 95% confidence interval (CI) 1.09–2.33). The middle up to the highest quintile of IGF1 was positively associated with high triglycerides in women. Metabolic syndrome was not a mediator in the U-shaped relationship of IGF1 with CVD. Both subjects without the metabolic syndrome and low IGF1 levels (hazard ratio (HR) 1.75, 95% CI 1.12–2.71) and subjects with the metabolic syndrome and high IGF1 levels (HR 2.28, 95% CI 1.21–4.28) demonstrated increased risks of CVD.ConclusionsIn older people, high-normal IGF1 levels are associated with prevalent metabolic syndrome and high triglycerides. Furthermore, this study suggests the presence of different pathomechanisms for both low and high IGF1 levels and incident CVD.

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