scholarly journals The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH

2007 ◽  
Vol 156 (4) ◽  
pp. 455-462 ◽  
Author(s):  
Agatha A van der Klaauw ◽  
Nienke R Biermasz ◽  
Edith J M Feskens ◽  
Marieke B Bos ◽  
Johannes W A Smit ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gh Deficiency ◽  
Density Lipoprotein ◽  
Population Based ◽  
The Metabolic Syndrome ◽  
Adult Gh Deficiency ◽  
Cardiovascular Morbidity And Mortality ◽  
Before And After ◽  
Using Data

Objectives: Many reports demonstrate improvements in cardiovascular risk factors during GH replacement (rhGH) in adult GH deficiency (GHD). However, it remains to be determined to what extent these changes translate into a reduction of increased cardiovascular morbidity and mortality. The aim of this study was to evaluate the effects of long-term rhGH replacement on the prevalence of the metabolic syndrome (MS). Design, settings, main outcome measures: The MS was scored by the National Cholesterol Education Program-Adult Treatment Panel III definition in 50 consecutive GHD patients (45 ± 9 years of age), before and after 2 and 5 years of rhGH replacement, and the data of untreated patients were compared with the general population using data from a Dutch population-based study (n = 1062, 44 ± 8 years of age). Results: Hypertriglyceridaemia (46.0 vs 18.5%, P < 0.0001), hypertension (66.0 vs 35.5%, P < 0.0001) and abdominal obesity (38.0 vs 23.4%, P = 0.0178) were more prevalent in untreated patients when compared with controls, resulting in a higher prevalence of the MS in patients (38.0 vs 15.7%, P < 0.0001). During rhGH replacement at a mean dose of 0.5 ± 0.2 mg/day resulting in IGF-I concentrations in the normal age-adjusted reference range, mean high-density lipoprotein cholesterol level increased compared with baseline (P < 0.001). However, the prevalence of (components of) the MS did not change after 2 or 5 years of treatment with rhGH. Conclusion: In this study, the prevalence of the MS in patients with GHD is increased compared with healthy controls, irrespective of rhGH replacement.

scholarly journals Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism

2017 ◽  
Vol 18 (2) ◽  
pp. 147032031770345 ◽  
Author(s):  
Sandro S Almeida ◽  
Flavia C Corgosinho ◽  
Carlos EN Amorim ◽  
Marcos F Gregnani ◽  
Raquel MS Campos ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Low Density Lipoprotein ◽  
Insulin Response ◽  
Density Lipoprotein ◽  
Fat Free Mass ◽  
Interdisciplinary Therapy ◽  
Obese Adolescents ◽  
Cholesterol Levels ◽  
The Metabolic Syndrome

Introduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents. Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes. Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response. Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy.

scholarly journals Plasma resistin levels correlate with determinants of the metabolic syndrome

2007 ◽  
Vol 156 (2) ◽  
pp. 279-284 ◽  
Author(s):  
G D Norata ◽  
M Ongari ◽  
K Garlaschelli ◽  
S Raselli ◽  
L Grigore ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Large Population ◽  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
Population Based ◽  
Atherosclerotic Lesions ◽  
The Metabolic Syndrome ◽  
Obese Subjects ◽  
Relationship Of

Objective: The role of resistin in insulin sensitivity and obesity is controversial. Some authors suggest that increased serum resistin levels are associated with obesity, visceral fat, insulin resistance, type 2 diabetes and inflammation, while others failed to observe such correlations. The aim of the present study was to investigate the relationship of plasma resistin levels with markers of the metabolic syndrome and atherosclerosis in a large population-based study. Design and patients: Plasma resistin levels were determined in 1090 subjects free of any medication selected from the PLIC study (designed to verify the presence of atherosclerotic lesions and progression intima-media thickness (IMT) in the common carotid artery in the general population) and related to the presence of obesity, metabolic syndrome, metabolic abnormalities, cardiovascular risk, and progression of IMT. Results: Plasma resistin levels were highly positively correlated with triglycerides, waist circumference, waist/hip ratio, systolic blood pressure, and ApoAI/ApoB ratio, while they were inversely correlated with high density lipoprotein and ApoAI levels. This finding was gender specific (mainly in women). Plasma resistin levels were significantly higher in women with the metabolic syndrome compared with controls (4.90 (0.24) ng/ml vs 3.90 (0.11) ng/ml; P<0.01), while no difference was observed in obese subjects. Finally, plasma resistin levels were significantlycorrelated with cardiovascular risk calculated according to the Framingham algorithm (P<0.01). Conclusion: Plasma resistin levels are increased in presence of the metabolic syndrome and are associated with increased cardiovascular risk.

The effect of the presence of the metabolic syndrome on the efficiency narrow-band uvb ultraviolet radiation (311) in patients with psoriasis

2020 ◽  
pp. 48-56
Author(s):  
Vadim Dmitruk ◽  
Svetlana Khardikova ◽  
Marina Gerasimenko ◽  
Inna Evstigneeva ◽  
Tatiana Zaitseva
Keyword(s):  
Metabolic Syndrome ◽  
Psoriasis Vulgaris ◽  
Narrow Band ◽  
The Metabolic Syndrome ◽  
Pathological Conditions ◽  
Tnf Α ◽  
High Prevalence ◽  
Before And After ◽  
Ammatory Cytokine

Backgraund: the researchers explain the high prevalence of metabolic syndrome among patients with psoriasis by the development of systemic infl ammation, which is considered as a single pathogenetic mechanism in these pathological conditions. The response of patients with psoriasis with metabolic syndrome to treatment with narrowband therapy is currently insuffi ciently studied. Aims: the study evaluated the effi cacy of narrowband therapy (311 nm) in patients with psoriasis associated with metabolic syndrome. Materials and methods: an objective and instrumental examination was conducted in 72 patients diagnosed with psoriasis vulgaris, after which a course of 20 procedures of narrow-cavity medium-wave ultraviolet irradiation (UFO) with a wavelength of 311 nm (B) was conducted. Patients were divided into 2 groups: patients with psoriasis and patients with psoriasis combined with metabolic syndrome. To assess the eff ectiveness of treatment, the index of the area and severity of psoriasis (PASI), lipid and carbohydrate metabolism; insulin and leptin; proinfl ammatory cytokines —IL-1β, IL-8, TNF-α and anti-infl ammatory cytokine IL-10 before and after the 10th, 20th procedure of UV-B therapy and 3 and 6 months after treatment. Results: а signifi cant decrease in PASI was observed in all patients with psoriasis after 10 procedures of UV-B therapy, but in the group of patients with metabolic syndrome, the PASI index was higher. After 20 procedures, Pasi reduction by more than 50 % was observed in the group of patients with psoriasis without manifestations of metabolic syndrome (р < 0,001). Indicators of lipid and carbohydrate blood metabolism in MS patients decreased (р < 0,05), the eff ect remained up to 6 months. The level of proinfl ammatory cytokines was increased in both groups, but in the group of patients with MS these indicators were higher. In the course of therapy cytokines decreased in both groups, the eff ect was maintained up to six months. On the contrary, IL-10 was reduced in both groups, and increased after our treatment, with the prolongation of the eff ect to 6 months. Conclusions: the appointment of UV-B therapy (311 nm) in patients with psoriasis with metabolic syndrome reduces the eff ectiveness of the course in the long term, which apparently requires repeated courses of narrowband therapy after 6 months.

scholarly journals Effect of Bariatric Surgery on the Metabolic Syndrome: A Population-Based, Long-term Controlled Study

2008 ◽  
Vol 83 (8) ◽  
pp. 897-906 ◽  
Author(s):  
John A. Batsis ◽  
Abel Romero-Corral ◽  
Maria L. Collazo-Clavell ◽  
Michael G. Sarr ◽  
Virend K. Somers ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Population Based ◽  
Controlled Study ◽  
The Metabolic Syndrome

scholarly journals Prevalence and characteristics of the metabolic syndrome in 2479 hypopituitary patients with adult-onset GH deficiency before GH replacement: a KIMS analysis

2011 ◽  
Vol 165 (6) ◽  
pp. 881-889 ◽  
Author(s):  
Johan Verhelst ◽  
Anders F Mattsson ◽  
Anton Luger ◽  
Maria Thunander ◽  
Miklós I Góth ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gh Deficiency ◽  
Normal Population ◽  
Prevalence Ratio ◽  
Cardiovascular Morbidity ◽  
Adult Onset ◽  
Gh Replacement ◽  
The Metabolic Syndrome ◽  
Cardiovascular Morbidity And Mortality ◽  
Increased Risk

ObjectiveAn increased risk of cardiovascular morbidity and mortality in adult GH deficiency (GHD) may be related to hypopituitarism but also to the presence of the metabolic syndrome (MetS). Our objective was to investigate the characteristics and prevalence of MetS as well as its comorbidities in adult GHD.DesignIn KIMS (Pfizer International Metabolic Database) 2479 patients with severe adult-onset GHD, naïve to GH replacement, with complete information on all MetS components were found. MetS was defined according to the National Cholesterol Education Program's Adult Treatment Panel III (NCEP) and the International Diabetes Foundation (IDF).MethodsThe prevalence of MetS was calculated and compared with previously published data from the normal population. Associations were assessed between background variables, baseline variables, comorbidities, and MetS.ResultsMetS was present in 43.1% (NCEP) and in 49.1% (IDF) of patients, clearly higher than data from the normal population (20–30%). MetS prevalence was related to age, GHD duration, and body mass index (BMI), but not to GHD severity, extent of hypopituitarism, or etiology of pituitary disease. Adjusted for age, gender, and BMI, patients with MetS had a higher prevalence ratio for diabetes mellitus: 4.65 (95% confidence interval (CI): 3.29–6.58), for cardiovascular morbidity: 1.91 (95% CI: 1.33–2.75), and for cerebrovascular morbidity: 1.77 (95% CI: 1.09–2.87) than patients without MetS.ConclusionsMetS is highly prevalent in GHD and is associated with a higher prevalence ratio for comorbidities. The presence of MetS in GHD may therefore contribute to the increased risk of cardiovascular morbidity and mortality found in these patients.

scholarly journals The Influence of the Metabolic Syndrome on the Short- and Long-Term Outcome After Carotid Endarterectomy

Angiology ◽  
2016 ◽  
Vol 68 (4) ◽  
pp. 306-314 ◽  
Author(s):  
Linda Visser ◽  
Bas M. Wallis de Vries ◽  
Douwe J. Mulder ◽  
Maarten Uyttenboogaart ◽  
Sterre van der Veen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Carotid Endarterectomy ◽  
Density Lipoprotein ◽  
High Serum ◽  
Serum Triglycerides ◽  
Term Outcome ◽  
Long Term Outcome ◽  
The Metabolic Syndrome ◽  
Short And Long Term

The metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular disease. The aim of this study is to determine the influence of MetS on short- and long-term outcome and survival after carotid endarterectomy (CEA). Between January 2005 and December 2014, data from all patients undergoing CEA were prospectively recorded. The metabolic syndrome was defined based on the presence of ≥3 of the following criteria: hypertension, high serum triglycerides, low levels of high-density lipoprotein cholesterol, high fasting serum glucose, and obesity. Primary end points were the occurrence of transient ischemic attack (TIA)/cerebrovascular accident (CVA), myocardial infarction, and mortality. A total of 564 interventions (in 525 patients) were performed, of which 244 (43.3%) were in patients who met the diagnosis of MetS. There were no differences in short- and long-term complications and overall survival between patients with and without MetS. Patients with diabetes mellitus (DM) had significantly more ipsilateral TIA/CVA after 30 days ( P = .001). The presence of MetS has no negative effect on the outcome after CEA. However, patients with DM have a significantly higher risk of ipsilateral TIA/CVA.

scholarly journals Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study

BMJ ◽  
2006 ◽  
Vol 332 (7546) ◽  
pp. 878-882 ◽  
Author(s):  
Johan Sundström ◽  
Ulf Risérus ◽  
Liisa Byberg ◽  
Björn Zethelius ◽  
Hans Lithell ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Cardiovascular Mortality ◽  
Population Based ◽  
Clinical Value ◽  
The Metabolic Syndrome ◽  
Term Prediction ◽  
Long Term Prediction

scholarly journals Effect of Bariatric Surgery on the Metabolic Syndrome: A Population-Based, Long-term Controlled Study

2008 ◽  
Vol 83 (8) ◽  
pp. 897-906 ◽  
Author(s):  
John A. Batsis ◽  
Abel Romero-Corral ◽  
Maria L. Collazo-Clavell ◽  
Michael G. Sarr ◽  
Virend K. Somers ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Population Based ◽  
Controlled Study ◽  
The Metabolic Syndrome

scholarly journals The Prevalence and Predictors of Hypertension and the Metabolic Syndrome in Police Personnel

2021 ◽  
Vol 18 (13) ◽  
pp. 6728
Author(s):  
James D. Yates ◽  
Jeffrey W. F. Aldous ◽  
Daniel P. Bailey ◽  
Angel M. Chater ◽  
Andrew C. S. Mitchell ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
Cross Sectional ◽  
Job Type ◽  
The Metabolic Syndrome ◽  
High Prevalence ◽  
Police Personnel ◽  
Behavioural Factors ◽  
Cardiometabolic Risk Markers ◽  
Police Forces

Hypertension and metabolic syndrome (METSYN) are reportedly high in police forces. This may contribute to health deterioration and absenteeism in police personnel. Police forces comprise of staff in ‘operational’ and ‘non-operational’ job types but it is not known if job type is associated to hypertension and METSYN prevalence. This study aimed to explore the prevalence of hypertension and METSYN, the factors associated with the risk of hypertension and METSYN, and compare physiological, psychological, and behavioural factors between operational and non-operational police personnel. Cross-sectional data was collected from 77 operational and 60 non-operational police workers. Hypertension and METSYN were prevalent in 60.5% and 20% of operational and 60.0% and 13.6% of non-operational police personnel, respectively (p > 0.05). Operational job type, moderate organisational stress (compared with low stress) and lower high-density lipoprotein cholesterol were associated with lower odds of hypertension, whereas increasing body mass index was associated with increased odds of hypertension (p < 0.05). None of the independent variables were significantly associated with the odds of METSYN. Operational police had several increased cardiometabolic risk markers compared with non-operational police. Given the high prevalence of hypertension and METSYN in operational and non-operational personnel, occupational health interventions are needed for the police and could be informed by the findings of this study.

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