scholarly journals Perceived intentional transmission of HIV infection, sustained viral suppression and psychosocial outcomes among men who have sex with men living with HIV: a cross-sectional assessment

2017 ◽  
Vol 94 (7) ◽  
pp. 483-486 ◽  
Author(s):  
Monique J Brown ◽  
Julianne M Serovich ◽  
Judy A Kimberly
Keyword(s):  
At Risk ◽  
Depressive Symptoms ◽  
Viral Suppression ◽  
Psychosocial Outcomes ◽  
Sexual Compulsivity ◽  
Clinical Depression ◽  
Sustained Viral Suppression ◽  
Condomless Anal Intercourse ◽  
Sex With Men ◽  
Living With Hiv

ObjectiveHIV continues to be a global and national public health challenge, and men who have sex with men (MSM) are disproportionately affected in the USA. Transmission of HIV is intentional if the person living with HIV knows about his/her serostatus, acts with the intention to and actually transmits HIV. Research on intentional transmission of HIV infections is lacking, and the relationships between perceived intentional transmission, viral suppression and psychosocial outcomes have not been assessed. The objective of this study was to investigate the association between perceived intentional transmission of HIV, sustained viral suppression and psychosocial outcomes.MethodsData were obtained from 338 MSM living with HIV who participated in a disclosure intervention study. Logistic and linear regression models were used to assess the associations between perceived intentional transmission and viral suppression, condomless anal intercourse in the past 30 days, being at risk for clinical depression, substance use, self-efficacies for condom use, HIV disclosure and negotiation of safer sex practices, and sexual compulsivity.Results44% of the study population reported perceiving intentional HIV transmission. After adjusting for sociodemographic characteristics, men who thought that they were infected intentionally had 69% higher odds (adjusted OR: 1.69; 95% CI 1.01 to 2.83) of being at risk for clinical depression, and on average, scored approximately 3 points and 4 points higher on depressive symptoms and sexual compulsivity, respectively (adjusted β: 3.29; 95% CI 0.42 to 6.15; adjusted β: 3.74; 95% CI 1.32 to 6.17) compared with men who did not think that they were intentionally infected. After adjusting for confounders, there was no statistically significant association between perceived intentional transmission and viral suppression.ConclusionsIntervention programmes for MSM living with HIV who thought they were infected intentionally are warranted and should aim to attenuate depressive symptoms and sexual compulsivity.

scholarly journals Social Capital, Depressive Symptoms, and HIV Viral Suppression Among Young Black, Gay, Bisexual and Other Men Who Have Sex with Men Living with HIV

2018 ◽  
Vol 22 (9) ◽  
pp. 3024-3032 ◽  
Author(s):  
Sophia A. Hussen ◽  
Kirk A. Easley ◽  
Justin C. Smith ◽  
Neeta Shenvi ◽  
Gary W. Harper ◽  
...  
Keyword(s):  
Social Capital ◽  
Depressive Symptoms ◽  
Viral Suppression ◽  
Hiv Viral Suppression ◽  
Sex With Men ◽  
Living With Hiv

scholarly journals Disparities by age in depressive symptoms and substance use among men who have sex with men living with HIV

2020 ◽  
Vol 31 (7) ◽  
pp. 642-651
Author(s):  
Monique J Brown ◽  
Julianne M Serovich ◽  
Tanja C Laschober ◽  
Judy A Kimberly
Keyword(s):  
Substance Abuse ◽  
Substance Use ◽  
Logistic Regression ◽  
Depressive Symptoms ◽  
Regression Models ◽  
Age Groups ◽  
Clinical Depression ◽  
Logistic Regression Models ◽  
Sex With Men ◽  
Living With Hiv

The aim of this study was to assess the association between age, depressive symptoms, and substance use among men who have sex with men (MSM) living with HIV. Baseline data were obtained from 337 MSM living with HIV. Linear and logistic regression models were used to determine the association between age and depressive symptoms and substance use. MSM aged 35–49 had higher depressive symptoms than MSM 50 and older (B = 3.53; 95% CI: 0.33, 6.72); MSM aged 25–34 and MSM 35–49 had higher substance use than MSM 50 and older (B = 2.66; 95% CI: 0.77, 4.54; and B = 1.68; 95% CI: 0.22, 3.14, respectively). MSM aged 35–49 were more likely to be at risk for clinical depression than MSM 50 and older (OR = 1.84; 95% CI: 1.06, 3.22); MSM aged 18–24 and MSM 35–49 were less likely and more likely to have substance abuse than MSM 50 and older (OR = 0.29; 95% CI: 0.09, 0.91; and OR = 1.83; 95% CI: 1.02, 3.29, respectively). Interventions addressing depressive symptoms and substance use tailored to individuals in different age groups should account for varying needs at different stages of life.

0474 DEPRESSIVE SYMPTOMS AND CLINICAL DEPRESSION IN PATIENTS AT RISK OF PSYCHOSIS

2006 ◽  
Vol 86 ◽  
pp. S94
Author(s):  
T.P. Svirskis ◽  
M. Heinimaa ◽  
J. Korkeila ◽  
L. Vaskelainen ◽  
J. Huttunen ◽  
...  
Keyword(s):  
At Risk ◽  
Depressive Symptoms ◽  
Clinical Depression ◽  
Patients At Risk

scholarly journals Pilot Trial of a Sexual Health Counseling Intervention for HIV-Positive Gay and Bisexual Men Who Report Anal Sex without Condoms

2021 ◽  
Author(s):  
Trevor A. Hart ◽  
Natalie Stratton ◽  
Todd A. Coleman ◽  
Holly A. Wilson ◽  
Scott H. Simpson ◽  
...  
Keyword(s):  
Sexual Transmission ◽  
Psychosocial Outcomes ◽  
Gay And Bisexual Men ◽  
Sexual Compulsivity ◽  
Hiv Positive ◽  
Bisexual Men ◽  
Anal Sex ◽  
Counseling Intervention ◽  
And Bisexual ◽  
Sex With Men

Background Even in the presence of promising biomedical treatment as prevention, HIV incidence among men who have sex with men has not always decreased. Counseling interventions, therefore, continue to play an important role in reducing HIV sexual transmission behaviors among gay and bisexual men and other men who have sex with men. The present study evaluated effects of a small-group counseling intervention on psychosocial outcomes and HIV sexual risk behavior. Method HIV-positive (HIV+) peer counselors administered seven 2-hour counseling sessions to groups of 5 to 8 HIV+ gay and bisexual men. The intervention employed information provision, motivational interviewing, and behavioral skills building to reduce sexual transmission risk behaviors. Results There was a significant reduction in condomless anal sex (CAS) with HIV-negative and unknown HIV-status partners, from 50.0% at baseline to 28.9% of the sample at 3-month follow-up. Findings were robust even when controlling for whether the participant had an undetectable viral load at baseline. Significant reductions were also found in the two secondary psychosocial outcomes, loneliness and sexual compulsivity. Conclusions The findings provide preliminary evidence that this intervention may offer an efficient way of concurrently reducing CAS and mental health problems, such as sexual compulsivity and loneliness, for HIV+ gay and bisexual men. Trial Registration ClinicalTrials.gov NCT02546271

scholarly journals AGE, DEPRESSIVE SYMPTOMS, AND SUBSTANCE USE AMONG MEN WHO HAVE SEX WITH MEN LIVING WITH HIV

2017 ◽  
Vol 1 (suppl_1) ◽  
pp. 714-715
Author(s):  
M.J. Brown ◽  
J. Serovich ◽  
J.A. Kimberly
Keyword(s):  
Substance Use ◽  
Depressive Symptoms ◽  
Sex With Men ◽  
Living With Hiv

scholarly journals Tobacco Use and Sustained Viral Suppression in Youth Living with HIV

2017 ◽  
Vol 22 (6) ◽  
pp. 2018-2025 ◽  
Author(s):  
Kristi E. Gamarel ◽  
◽  
Andrew O. Westfall ◽  
Michelle A. Lally ◽  
Sybil Hosek ◽  
...  
Keyword(s):  
Tobacco Use ◽  
Viral Suppression ◽  
Sustained Viral Suppression ◽  
Youth Living With Hiv ◽  
Living With Hiv

scholarly journals Increasing HIV Testing and Viral Suppression via Stigma Reduction in a Social Networking Mobile Health Intervention Among Black and Latinx Young Men and Transgender Women Who Have Sex With Men (HealthMpowerment): Protocol for a Randomized Controlled Trial

10.2196/24043 ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. e24043
Author(s):  
Kathryn Elizabeth Muessig ◽  
Jesse M Golinkoff ◽  
Lisa B Hightow-Weidman ◽  
Aimee E Rochelle ◽  
Marta I Mulawa ◽  
...  
Keyword(s):  
Hiv Testing ◽  
Viral Suppression ◽  
The United States ◽  
Hiv Care ◽  
Hiv Status ◽  
Mhealth Intervention ◽  
Sex With Men ◽  
The University ◽  
Living With Hiv ◽  
Hiv Negative

Background Stigma and discrimination related to sexuality, race, ethnicity, and HIV status negatively impact HIV testing, engagement in care, and consistent viral suppression (VS) among young Black and Latinx men who have sex with men and transgender women who have sex with men (YBLMT). Few interventions address the effects of intersectional stigma among youth living with HIV and those at risk for HIV within the same virtual space. Objective Building on the success of the HealthMpowerment (HMP) mobile health (mHealth) intervention (HMP 1.0) and with the input of a youth advisory board, HMP 2.0 is an app-based intervention that promotes user-generated content and social support to reduce intersectional stigma and improve HIV-related outcomes among YBLMT. The primary objective of this study is to test whether participants randomized to HMP 2.0 report improvement in HIV prevention and care continuum outcomes compared with an information-only control arm. We will also explore whether participant engagement, as measured by paradata (data collected as users interact with an mHealth intervention, eg, time spent using the intervention), mediates stigma- and HIV care–related outcomes. Finally, we will assess whether changes in intersectional stigma and improvements in HIV care continuum outcomes vary across different types of social networks formed within the intervention study arms. Methods We will enroll 1050 YBLMT aged 15 to 29 years affected by HIV across the United States. Using an HIV-status stratified, randomized trial design, participants will be randomly assigned to 1 of the 3 app-based conditions (information-only app-based control arm, a researcher-created network arm of HMP 2.0, or a peer-referred network arm of HMP 2.0). Behavioral assessments will occur at baseline, 3, 6, 9, and 12 months. For participants living with HIV, self-collected biomarkers (viral load) are scheduled for baseline, 6, and 12 months. For HIV-negative participants, up to 3 HIV self-testing kits will be available during the study period. Results Research activities began in September 2018 and are ongoing. The University of Pennsylvania is the central institutional review board for this study (protocol #829805) with institutional reliance agreements with the University of North Carolina at Chapel Hill, Duke University, and SUNY Downstate Health Sciences University. Study recruitment began on July 20, 2020. A total of 205 participants have been enrolled as of November 20, 2020. Conclusions Among a large sample of US-based YBLMT, this study will assess whether HMP 2.0, an app-based intervention designed to ameliorate stigma and its negative sequelae, can increase routine HIV testing among HIV-negative participants and consistent VS among participants living with HIV. If efficacious and brought to scale, this intervention has the potential to significantly impact the disproportionate burden of HIV among YBLMT in the United States. Trial Registration ClinicalTrials.gov NCT03678181; https://clinicaltrials.gov/ct2/show/study/NCT03678181. International Registered Report Identifier (IRRID) DERR1-10.2196/24043

scholarly journals Viral Reservoir in Early-Treated HIV-Infected Children and Markers for Sustained Viral Suppression

2021 ◽  
Author(s):  
Gbolahan Ajibola ◽  
Pilar Garcia-Broncano ◽  
Kenneth Maswabi ◽  
Kara Bennett ◽  
Michael D Hughes ◽  
...  
Keyword(s):  
Viral Suppression ◽  
Treatment Success ◽  
Viral Reservoir ◽  
Hiv Dna ◽  
Sustained Viral Suppression ◽  
Early Infant ◽  
Living With Hiv ◽  
The Impact ◽  
Plasma Rna ◽  
Dna Pcr

Abstract Background The impact of very early infant treatment on HIV reservoir, and markers for treatment success, require study. Methods The Early Infant Treatment Study (EIT) enrolled 40 children living with HIV started on antiretroviral treatment (ART) at <7 days of age and 23 who had started treatment between 30-365 days to serve as controls. Quantitative HIV DNA was evaluated every 1-3 months in PBMCs. 84-week repeat qualitative whole blood DNA PCR and dual enzyme EIA were performed. Results Median quantitative cell-associated DNA after at least 84 weeks was significantly lower among the first 27 EIT children tested than among 10 controls (40.8 vs. 981.4 copies/million cells; p<0.001) and correlated with pre-ART DNA. Median DNA after 84 weeks did not differ significantly by negative or positive serostatus at 84 weeks (p=0.94), and appeared unaffected by periods of unsuppressed plasma RNA from 24-84 weeks (p=0.70). However, negative 84-week serostatus was 67% predictive for sustained RNA suppression and positive serostatus was 100% predictive for viremia. Loss of qualitative DNA positivity at 84 weeks was 73% predictive for sustained suppression and persistent positivity was 77% predictive for viremia. Conclusions Lower viral reservoir was associated with starting ART at <1 week. Negative serostatus and qualitative DNA were useful markers of sustained viral suppression from 24-84 weeks.

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