scholarly journals P87 The Impact of Respiratory Viruses and Pulmonary Exacerbations on FEV1 Decline in Adults with Cystic Fibrosis

Thorax ◽  
2012 ◽  
Vol 67 (Suppl 2) ◽  
pp. A101.3-A102
Author(s):  
WG Flight ◽  
KJ Mutton ◽  
AK Webb ◽  
RJ Bright-Thomas ◽  
AM Jones
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Viruses ◽  
Pulmonary Exacerbations ◽  
The Impact ◽  
Fev1 Decline

scholarly journals Pulmonary exacerbations as a risk factor for lung function decline-experiences of the National Cystic Fibrosis Center

2019 ◽  
Vol 76 (11) ◽  
pp. 1110-1114
Author(s):  
Bojana Gojsina ◽  
Milan Rodic ◽  
Jelena Visekruna ◽  
Goran Trajkovic ◽  
Aleksandar Sovtic ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Burkholderia Cepacia ◽  
Negative Impact ◽  
Bacterial Colonization ◽  
Forced Expiratory Volume ◽  
Lung Function Decline ◽  
Pulmonary Exacerbations ◽  
Fev1 Decline

Background/Aim. Pulmonary exacerbations have negative impact on clinical course of cystic fibrosis (CF) lung disease being associated with a steeper decline in the lung function, unfavorable prognosis and impaired quality of life. The aim of this study was to determine whether an increased number of exacerbations had influence on the lung function in the patients with CF, as well as to estimate the nutritional status, gender, presence of comorbid conditions and bacterial colonization of airways as predictive factors for pulmonary exacerbations. Methods. This retrospective cohort study included 83 pediatric and adult patients, treated from 2011? 2015 in the Mother and Child Health Institute of Serbia ?Dr Vukan Cupic?. The best result of forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) in each year of follow-up was taken into account to calculate the five-year trend values of these indicators. The number of exacerbations per year of follow-up and its impact on the FEV1 decline was evaluated. Results. Mean annual decline of FEV1 and FVC were 2.4% and 1.7% respectively. The malnourished patients had the lower initial values of FEV1 and FVC, and more frequent exacerbations in comparison with the normal weight and overweight patients. The frequency of exacerbations was significantly higher in the patients chronically colonized with Burkholderia cepacia (p = 0.023). The increased number of exacerbation was proved to be the most important factor in a prediction of FEV1 decline over time (p = 0.013). Conclusion. Pulmonary exacerbations lead to the more progressive lung function decline in the patients with CF. Malnourishment and chronic airway colonization with Burkholderia cepacia result in more frequent pulmonary exacerbations.

The Effects Of Respiratory Viruses on The Acute Pulmonary Exacerbations In Cystic Fibrosis Patients

2019 ◽  
Author(s):  
Mina Gharibzadeh Hizal ◽  
Ebru Yalcin ◽  
Alpaslan Alp ◽  
Sanem Eryılmaz Polat ◽  
Meltem Ozden ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Viruses ◽  
Pulmonary Exacerbations

Pulmonary exacerbations are associated with subsequent FEV1 decline in both adults and children with cystic fibrosis

2010 ◽  
Vol 46 (4) ◽  
pp. 393-400 ◽  
Author(s):  
Don B. Sanders ◽  
Rachel CL. Bittner ◽  
Margaret Rosenfeld ◽  
Gregory J. Redding ◽  
Christopher H. Goss
Keyword(s):  
Cystic Fibrosis ◽  
Adults And Children ◽  
Pulmonary Exacerbations ◽  
Fev1 Decline

scholarly journals The Effects of Respiratory Viruses on the Acute Pulmonary Exacerbations in Cystic Fibrosis Patients

2019 ◽  
Vol 20 (-1) ◽  
pp. 102-102
Author(s):  
Mina Gharibzadeh Hizal ◽  
◽  
Ebru Yalcin ◽  
Alpaslan Alp ◽  
Meltem Ozden ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Viruses ◽  
Pulmonary Exacerbations

scholarly journals Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis

2012 ◽  
Vol 11 (5) ◽  
pp. 433-439 ◽  
Author(s):  
Sandra Asner ◽  
Valerie Waters ◽  
Melinda Solomon ◽  
Yvonne Yau ◽  
Susan E. Richardson ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Viruses ◽  
Pulmonary Exacerbations

Utility of Second-Look Endoscopy with Debridement After Pediatric Functional Endoscopic Sinus Surgery in Patients with Cystic Fibrosis

2020 ◽  
Vol 129 (12) ◽  
pp. 1153-1162
Author(s):  
Zachary M. Helmen ◽  
Ryan E. Little ◽  
Thomas Robey
Keyword(s):  
Cystic Fibrosis ◽  
Endoscopic Sinus Surgery ◽  
Tertiary Care ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
P Value ◽  
Second Look ◽  
Significant Difference ◽  
Pulmonary Exacerbations ◽  
The Impact

Objectives: To determine the utility of Second-look endoscopy with debridement (SLED) after functional endoscopic sinus surgery (ESS) in pediatric cystic fibrosis (CF) patients. To compare outcomes in pediatric CF patients undergoing sinus surgery for chronic sinusitis with or without SLED. To describe findings present at the time of SLED. Methods: Retrospective chart review of 61 ESS procedures performed at a tertiary care pediatric center from 2013 to 2016. Data collected included demographics, SLED findings, and 6-month pre-/postoperative disease specific outcomes including incidence of sinonasal and pulmonary exacerbations and revisions. Results: Sixty-one cases were reviewed. SLED was performed in 38 cases on average 22.4 days postoperatively. Average preoperative Lund-Mackay score was 14.9 and 14.8 among patients undergoing ESS with and without SLED, respectively. Pre-/postoperative intranasal steroid use and extent of surgery performed was similar among all patients. At the time of SLED, rates of synechiae, polyps and maxillary antrostomy obstruction were 26.3%, 23.7%, and 7.9%, respectively. The incidence and number of days to onset of postoperative sinonasal exacerbations requiring antibiotic therapy within 6 months of ESS were 1.0 (SD 1.0) and 85 days (SD 45.7); and 1.3 (SD 1.0) and 80.4 days (SD 40.5) for patients undergoing ESS with and without SLED, respectively ( P value .33). The number of days to first pulmonary exacerbation was 113.9 (SD 45.5) and 47.4 (SD 34.1) among SLED and non-SLED patients, respectively ( P value .01). No significant difference was observed in revision rates and time to revision ESS (30% and overall average 1.4 years, respectively). Conclusion: The utility of SLED among pediatric CF patients remains unclear. While debridement did not have a significant impact on sinonasal exacerbations or revision rates, pulmonary exacerbations for patients undergoing SLED were delayed. Further studies are needed to clarify the impact of SLED.

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