S104 Investigating the diagnostic performance of specific immunological tests in occupational asthma

Background. The risks of occupational asthma (OA) from antibiotics are uncertain. We report 4 new cases and a systematic review of the literature. Methods. Cases were identified through a specialist clinic, each underwent specific provocation testing (SPT). We subsequently reviewed the published literature. Results. The patients were employed in the manufacture of antibiotics; penicillins were implicated in three cases, in the fourth erythromycin, not previously reported to cause OA. In two, there was evidence of specific IgE sensitisation. At SPT each developed a late asthmatic reaction and increased bronchial hyperresponsiveness. 36 case reports have been previously published, 26 (citing penicillins or cephalosporins). Seven cross-sectional workplace-based surveys found prevalences of 5–8%. Conclusions. OA in antibiotic manufacturers may be more common than is generally recognised. Its pathogenesis remains unclear; immunological tests are of uncertain value and potential cases require confirmation with SPT. Further study of its frequency, mechanisms, and diagnosis is required.

Download Full-text

Diagnostic performance of two specific schistosoma japonicum immunological tests for screening schistosoma haematobium in school children in Zambia

Acta Tropica ◽

10.1016/j.actatropica.2019.105285 ◽

2020 ◽

Vol 202 ◽

pp. 105285

Author(s):

Li-Juan Zhang ◽

Victor Mwanakasale ◽

Jing Xu ◽

Le-Ping Sun ◽

Xiao-Mei Yin ◽

...

Keyword(s):

Schistosoma Japonicum ◽

School Children ◽

Schistosoma Haematobium ◽

Diagnostic Performance ◽

Immunological Tests

Download Full-text

Occupational Asthma in Hospital Healthcare Worker

Jurnal Respirologi Indonesia ◽

10.36497/jri.v40i4.126 ◽

2020 ◽

Vol 40 (4) ◽

pp. 262-269

Author(s):

Rahmad Budianto ◽

Tri Wahju Astuti

Keyword(s):

Occupational Asthma ◽

Health Workers ◽

Pharmacological Therapy ◽

Adult Onset ◽

Test Management ◽

Asthma Symptoms ◽

Immunological Tests ◽

Causative Agents ◽

Immunological Reactions ◽

Prevention Of Disability

Occupational asthma is defined as an adult onset of asthma triggered by specific exposures or combinations from the workplace. Occupational asthma is classified into a sensitizer-induced occupational asthma or allergic occupational asthma caused by exposure or sensitization by a causative agents induced by immunological reactions; and irritant-induced occupational asthma or non-allergic occupational asthma caused by agents that are irritative to the airway. Occupational asthma can occur in health workers at hospitals. In the hospital there are various exposure of agents, medicines, and health equipments which can induce the asthma symptoms for health workers. The diagnosis of occupational asthma established by history taking, physical examination, supporting examination (spirometry, bronchial hyper-responsiveness test, exhaled nitric oxide, and immunological tests), and biomarker test. Management of occupational asthma includes principle management by avoiding exposure, pharmacological therapy, and immunotherapy. Precautions taken by primary, secondary (medical surveilance) and tertiary prevention (prevention of disability through worker’s compensation system).

Download Full-text