Radiographic, computed tomographic and histopathological characteristics of multilobar congenital pulmonary emphysema in a puppy

2020 ◽  
Vol 8 (2) ◽  
pp. e001125
Author(s):  
Sarah Bouyssou ◽  
Inigo Sanz ◽  
Francesco Marchesi ◽  
Caroline Eivers
Keyword(s):  
Respiratory Distress ◽  
Pulmonary Emphysema ◽  
Rare Case ◽  
Acute Onset ◽  
Labrador Retriever ◽  
Lung Field ◽  
Cystic Lesions ◽  
Congenital Lobar Emphysema ◽  
Computed Tomographic ◽  
Lobar Emphysema

A 10-week-old male entire Labrador retriever was presented for evaluation of acute-onset coughing and respiratory distress. Radiographic and CT examination of the thorax revealed the presence of multifocal and numerous gas-filled cystic lesions throughout the lung field and a mild pneumothorax. Gross pathological and histopathological findings were consistent with congenital lobar emphysema due to bronchial cartilage dysplasia/hypoplasia and possible congenital bronchiectasis. This is the first report describing combined radiographic and CT characteristics of a rare case of multilobar congenital pulmonary emphysema in a puppy.

scholarly journals Congenital lobar emphysema in adult: A rare case report

2010 ◽  
Vol 3 (3) ◽  
pp. 150-152 ◽  
Author(s):  
M. Khalid ◽  
S. Saleemi ◽  
B. Khan
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Congenital Lobar Emphysema ◽  
Rare Case Report ◽  
Lobar Emphysema

scholarly journals Congenital lobar emphysema: a rare cause of respiratory distress in a neonate

2018 ◽  
Vol 6 (1) ◽  
pp. 218
Author(s):  
Nishant Mittal ◽  
Ankit Parakh ◽  
Prashant Jain ◽  
N. K. Mittal
Keyword(s):  
Early Intervention ◽  
Respiratory Distress ◽  
Treatment Options ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Congenital Lobar Emphysema ◽  
Congenital Condition ◽  
Lobar Emphysema ◽  
Intervention Message ◽  
The Right

Congenital lobar emphysema (CLE) is a congenital condition characterized by distension and air trapping of the affected lobe of the lung. It is one of the causes of infantile respiratory distress, which may require surgical resection of affected lobe. Case characteristics: 3-day-old neonate with ventilation refractory respiratory distress. Imaging was suggestive of decreased lung tissue on the right side with ipsilateral mediastinal shift. Intervention/ outcome: Early surgical lobectomy was done to improve lung functions and the child improved dur to early intervention. Message: An early diagnosis with high index of suspicion helps patients with this rare congenital anomaly. Early intervention is the key to good long-term outcome. More awareness about the entity and treatment options available would greatly help improving the outcome and disease burden.

Acute Worsening of Congenital Lobar Emphysema with Subsequent Spontaneous Improvement

PEDIATRICS ◽  
1983 ◽  
Vol 71 (5) ◽  
pp. 844-848
Author(s):  
WAYNE J. MORGAN ◽  
RICHARD J. LEMEN ◽  
RODRIGO ROJAS
Keyword(s):  
Respiratory Distress ◽  
Clinical Status ◽  
Respiratory Illness ◽  
Acute Respiratory Tract Infection ◽  
Base Line ◽  
Sudden Increase ◽  
Respiratory Dysfunction ◽  
Congenital Lobar Emphysema ◽  
Spontaneous Improvement ◽  
Lobar Emphysema

The degree of respiratory dysfunction and subsequent morbidity of patients with congenital lobar emphysema (CLE) are related to the degree of hyperinflation of the involved lobe.1 Whereas neonates with severe CLE may have marked respiratory distress requiring surgical resection of the hyperinflated lobe, children with mild forms of CLE seldom have a sudden increase in size of the involved lobe leading to respiratory failure.2,3 We report two infants with mild CLE who were clinically stable and developed respiratory distress with increased hyperinflation of the involved lobe associated with an acute respiratory tract infection. Both infants returned to their base line clinical status with conservative therapy alone following resolution of their respiratory illness.

scholarly journals Not all infantile respiratory distress in winter is bronchiolitis: congenital lobar emphysema

2011 ◽  
Vol 2011 (oct20 1) ◽  
pp. bcr0820114618-bcr0820114618 ◽  
Author(s):  
L. Taqvi ◽  
M. Griksaitis ◽  
K. Eastham
Keyword(s):  
Respiratory Distress ◽  
Congenital Lobar Emphysema ◽  
Lobar Emphysema

scholarly journals Congenital lobar emphysema presenting at late childhood: A rare case report

Lung India ◽  
2014 ◽  
Vol 31 (3) ◽  
pp. 302 ◽  
Author(s):  
Avradip Santra ◽  
Pravati Dutta ◽  
Rekha Manjhi ◽  
Sudarsan Pothal
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Late Childhood ◽  
Congenital Lobar Emphysema ◽  
Rare Case Report ◽  
Lobar Emphysema

scholarly journals Congenital lobar emphysema: a rare cause for respiratory distress in newborns and

2018 ◽  
Vol 36 (3) ◽  
pp. 3
Author(s):  
I. H. D. S Pradeep ◽  
Dhammika Rasnayaka ◽  
Ridma Jayarathna
Keyword(s):  
Respiratory Distress ◽  
Congenital Lobar Emphysema ◽  
Lobar Emphysema

scholarly journals Spontaneous pulmonary emphysema in mice lacking all three nitric oxide synthase isoforms

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kaori Kato ◽  
Masato Tsutsui ◽  
Shingo Noguchi ◽  
Yukitoshi Iha ◽  
Keisuke Naito ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mrna Expression ◽  
Pulmonary Emphysema ◽  
Elastic Fiber ◽  
Lung Field ◽  
Expression Levels ◽  
Computed Tomographic ◽  
Cap Analysis ◽  
Mrna Expression Levels

AbstractThe roles of endogenous nitric oxide (NO) derived from the entire NO synthases (NOSs) system have yet to be fully elucidated. We addressed this issue in mice in which all three NOS isoforms were deleted. Under basal conditions, the triple n/i/eNOSs−/− mice displayed significantly longer mean alveolar linear intercept length, increased alveolar destructive index, reduced lung elastic fiber content, lower lung field computed tomographic value, and greater end-expiratory lung volume as compared with wild-type (WT) mice. None of single NOS−/− or double NOSs−/− genotypes showed such features. These findings were observed in the triple n/i/eNOSs−/− mice as early as 4 weeks after birth. Cyclopaedic and quantitative comparisons of mRNA expression levels between the lungs of WT and triple n/i/eNOSs−/− mice by cap analysis of gene expression (CAGE) revealed that mRNA expression levels of three Wnt ligands and ten Wnt/β-catenin signaling components were significantly reduced in the lungs of triple n/i/eNOSs−/− mice. These results provide the first direct evidence that complete disruption of all three NOS genes results in spontaneous pulmonary emphysema in juvenile mice in vivo possibly through down-regulation of the Wnt/β-catenin signaling pathway, demonstrating a novel preventive role of the endogenous NO/NOS system in the occurrence of pulmonary emphysema.

scholarly journals Congenital Lobar Emphysema: Perioperative Evaluation and Management

2021 ◽  
Vol 24 (3) ◽  
pp. E517-E521
Author(s):  
Montaser Elsawy Abd Elaziz ◽  
Mohamed Gaber Elsayed ◽  
Mohamed Ahmed El-hag Aly
Keyword(s):  
Respiratory Distress ◽  
Surgical Management ◽  
University Hospital ◽  
Recurrent Pneumonia ◽  
Diagnostic Modality ◽  
Early Management ◽  
Congenital Lobar Emphysema ◽  
The Mean ◽  
Lobar Emphysema

Background: Congenital lobar emphysema (CLE) is a lung malformation characterized by overdistension and air trapping in the affected lobe. It is one of the causes of neonatal and infantile respiratory distress. This study aimed to evaluate our experience regarding perioperative and surgical management in children with CLE. Methods: A retrospective observational study was done for all CLE patients who underwent surgery at Menoufia University Hospital. Perioperative data collected included demographic, clinical, and radiological findings, as well as operative and postoperative data. Results: We included 30 neonates and infants who suffered from CLE between January 2013 and December 2020; the mean age was 111.43 ± 65.19 days, and 21 were males. All cases presented with respiratory distress; 19 had cyanosis, and 15 had recurrent pneumonia and fever. Plain chest x-ray and computed tomography (CT) revealed emphysema in all cases. Lobectomy was done in all cases; the mean age at surgery was 147.58 ± 81.49 days. Postoperative complications occurred in 5 patients, and 2 of them needed mechanical ventilation. The follow-up duration ranged from 3 months to 1 year (except 1 case lost to follow-up after 3 months), and all patients were doing well. Conclusion: CLE is a rare bronchopulmonary malformation that requires a high index of clinical suspicion, especially in persistent and recurrent infantile respiratory distress. Chest CT is the most useful diagnostic modality. Early management of CLE improves outcome and prevents life-threatening complications. Surgical management is the treatment of choice in our center, without recorded mortality.

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