BACKGROUND
Background:H19 gene is maternally expressed imprinted oncofetal gene. This study aimed to explore distribution pattern and intellectual structure of H19 in cancer.
OBJECTIVE
Published scientific 826 papers related to H19 from Jan 1st, 2000 to March 22st, 2019 were obtained from the Web of Science core collection.
METHODS
We performed extraction of keywords and co-word matrix construction using BICOMB software. Then gCLUTO software, ucinet, excel software, Citespace, Vosviewer were successfully used for double -cluster analysis, social network analysis, Strategic coordinate analysis, co-citation analysis, and journal analysis.
RESULTS
We analyzed the distributions of included article of H19, identified 34 high-frequency keywords and classified them into 6 categories. Through co-word analysis and co-citation analysis for these categories, we identified the hotspot areas and intellectual basis about H19 in cancer research. Then the prospects of hotspots and their associations were accesssed by strategic coordinate diagrams and social network diagrams.
CONCLUSIONS
6 research categories of 34 high-frequency keywords could represent the theme trends on H19 to some extent. Mir-675, cancer metastasis and risk, Wnt/β-catenin signaling pathway, SNP, and ceRNA network were core and mature research areas in this field. There is a lack of promising areas of H19 research. Matouk(2006) article play a key role in H19 research, and Murphy SK(2006)and Luo M(2013) articles serve knowledge transmission as pivotal study.
