scholarly journals IGF-1 colocalizes with muscle satellite cells following acute exercise in humans

2014 ◽  
Vol 39 (4) ◽  
pp. 514-518 ◽  
Author(s):  
Amanda Grubb ◽  
Sophie Joanisse ◽  
Daniel R. Moore ◽  
Leeann M. Bellamy ◽  
Cameron J. Mitchell ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Growth Factor ◽  
Satellite Cells ◽  
Acute Exercise ◽  
Stem Cell Proliferation ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Exercise In Humans

Insulin-like growth factor-1 (IGF-1) regulates stem cell proliferation and differentiation in vitro. The aim of this study was to quantify the change in satellite cell (SC) specific IGF-1 colocalization following exercise. We observed a significant increase (p < 0.05) in the percentage of SC with IGF-1 colocalization from baseline to 72 h after a bout of resistance exercise. This strongly supports a role for IGF-1 in human SC function following exercise.

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