Modified cancer TNM classification for localized renal cell carcinoma based on the prognostic analysis of 3748 cases from a single center

2021 ◽  
pp. 1-7
Author(s):  
Jian Zhang ◽  
Xiaoli Li ◽  
Jun Lin ◽  
Zhijia Liu ◽  
Ye Tian ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Staging System ◽  
Tnm Staging ◽  
Tumor Diameter ◽  
Optimal Cutoff ◽  
Tnm Staging System ◽  
Optimal Cutoff Point ◽  
T1 And T2 ◽  
Localized Renal Cell Carcinoma

The optimal cutoff point for evaluating the prognosis of localized renal cell carcinoma (LRCC) remains unclear. This study aimed to verify the efficacy of tumor diameter in the 2010 American Joint Committee on Cancer (AJCC) TNM staging system and contribute to the modification of TNM staging on the prognosis of this disease. A total of 3748 patients with LRCC were enrolled and grouped according to the 2010 AJCC TNM staging system. COX analysis was used to stratify the prognosis. The optimal cutoff point of the tumor diameter in the T1 and T2 prognosis was explored. There were 3330 (88.9%) patients in stage T1 and 418 (11.1%) in stage T2. The cancer-specific mortality rate was 2.7% (100/3748). The mean follow-up was 49.8 months. A tumor diameter of 7 cm can determine the prognosis of patients at stages T1 and T2; however, 4.5 cm and 11 cm as the cutoff points for T1 and T2 sub-classification of patients with LRCC might show better recognition ability than 4 cm and 10 cm, respectively. The 2010 AJCC TNM stage can predict the prognosis of LRCC in stages T1 and T2. In addition, a tumor diameter of 4.5 cm and 11 cm might be the optimal cutoff points for the sub-classification of stages T1 and T2.

scholarly journals Modified Cancer TNM Classification for Localized Renal Cell Carcinoma based on the Prognostic Analysis of 3748 Cases from a Single Center

2020 ◽  
Author(s):  
Jian Zhang ◽  
Xiaoli Li ◽  
Jun Lin ◽  
Zhijia Liu ◽  
Changqing Chen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Staging System ◽  
Tnm Staging ◽  
Tumor Diameter ◽  
Tnm Staging System ◽  
Optimal Cutoff Point ◽  
T1 And T2 ◽  
Localized Renal Cell Carcinoma

Abstract Background The optimal cutoff point for evaluating the prognosis of localized renal cell carcinoma remains unclear. The study aimed to verify the efficacy of tumor diameter in the 2010 AJCC TNM staging system and put forward modification for TNM staging on the prognosis. Methods 3748 patients with localized renal cell carcinoma were enrolled and grouped according to the 2010 AJCC TNM staging system. COX analysis was used to stratify the prognosis and optimal cutoff point of the tumor diameter in the T1 and T2 prognosis was explored. Results 3330 (88.9%) were in stage T1 and 418 (11.1%) were in stage T2. The cancer-specific mortality rate was 2.7% (100/3748). Mean follow-up was 49.8 months. The analysis of tumor diameter at 7 cm can greatly determine the prognosis of patients at stages T1 and T2. However, the tumor diameters of 4.5 and 11 cm set as the cutoff points for T1 and T2 subclassifications of patients with LRCC seemed to have better recognition ability than 4 and 10 cm, respectively. Conclusions The 2010 AJCC TNM stage can greatly predict the prognosis of LRCC in stages T1 and T2. In addition, 4.5 and 11 cm might be optional cutoff points for the tumor diameters for subclassifying stages T1 and T2.

scholarly journals Multiinstitutional European validation of the 2002 TNM staging system in conventional and papillary localized renal cell carcinoma

Cancer ◽  
2005 ◽  
Vol 104 (5) ◽  
pp. 968-974 ◽  
Author(s):  
Vincenzo Ficarra ◽  
Luigi Schips ◽  
François Guillè ◽  
Guorong Li ◽  
Alexandre De La Taille ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System ◽  
Localized Renal Cell Carcinoma

Proposal for Reclassification of the TNM Staging System in Patients with Locally Advanced (pT3–4) Renal Cell Carcinoma According to the Cancer-Related Outcome

2007 ◽  
Vol 51 (3) ◽  
pp. 722-731 ◽  
Author(s):  
Vincenzo Ficarra ◽  
Giacomo Novara ◽  
Massimo Iafrate ◽  
Livio Cappellaro ◽  
Emiliano Bratti ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Locally Advanced ◽  
Staging System ◽  
Tnm Staging ◽  
Tnm Staging System

532 PROGNOSTIC ACCURACY OF THE 2009 UICC/AJCC TNM STAGING SYSTEM FOR RENAL CELL CARCINOMA WITH VENOUS EXTENSION

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Juan Ignacio Martinez-Salamanca ◽  
William Huang ◽  
Isabel Millan ◽  
Roberto Bertini ◽  
Fernando Bianco ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Staging System ◽  
Tnm Staging ◽  
Prognostic Accuracy ◽  
Tnm Staging System

Independent validation of the 2002 UICC TNM staging system for papillary renal cell carcinoma in a multicenter cohort

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 5092-5092
Author(s):  
C. Wulfing ◽  
E. Herrmann ◽  
L. Trojan ◽  
A. Schrader ◽  
F. Becker ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Multivariate Analysis ◽  
Metastatic Disease ◽  
Renal Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Staging System ◽  
Tnm Staging ◽  
Cancer Specific Survival ◽  
Tnm Staging System

5092 Background: Papillary renal cell carcinoma (pRCC) is the second most malignant histologic subtype in nephrectomy specimens. To date, the most recognized staging system to stratify renal cancer patients is the 2002 UICC TNM classification system. Its accuracy for predicting patient outcome for pRCC is unknown. Methods: From ten urologic institutions in Germany follow-up data on 675 patients with pRCC were collected. In most cases histologic slides were available and central pathologic review was performed. The Kaplan-Meier method was used to derive the cumulative cancer-specific survival. For multivariate analysis of prognostic factors, a Cox regression analysis was performed. Results: 498 (74.1%) patients had organ-confined tumor stages (≤pT2). Synchronous distant metastases in the entire group occurred in 58 (8.7%) patients and 69 (11.2%) others developed metastatic disease during follow-up. Cancer-specific survival (CSS) was significantly related to TNM stage and histologic grading in univariate as well as in multivariate analysis (all p < 0.0001). 5-year CSS in pT1b tumors (90.0%) was significantly shorter compared to pT1a tumors (98.3%) (p = 0.017). Patients with ≥pT3 were at high risk for metastases (50.6%), while metastatic disease associated with ≤pT2 tumors occurred in 7.8% (p < 0.0001). Once metastatic disease was present, prognosis was poor (5-year CSS: 7.2%). Age was associated with a worse prognosis in the subgroup of ≥pT3 tumors in univariate (p = 0.026), but not in multivariate analysis. Conclusions: The 2002 UICC TNM staging system is applicable for pRCC. Clinical and radiologic follow-ups should be offered in frequent intervals to patients with venous thrombus and/or locally advanced disease. The role of age remains unclear, but should not be underestimated at risk stratification after tumor resection. No significant financial relationships to disclose.

Prognostic Impact of the 2009 UICC/AJCC TNM Staging System for Renal Cell Carcinoma with Venous Extension

2011 ◽  
Vol 59 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Juan I. Martínez-Salamanca ◽  
William C. Huang ◽  
Isabel Millán ◽  
Roberto Bertini ◽  
Fernando J. Bianco ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Staging System ◽  
Tnm Staging ◽  
Prognostic Impact ◽  
Tnm Staging System
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