FLUID, ELECTROLYTE, GASTROINTESTINAL, AND HAIR CHANGES IN ADRENALECTOMIZED-SYMPATHECTOMIZED DOGS

1957 ◽  
Vol 35 (11) ◽  
pp. 983-992
Author(s):  
R. A. Cleghorn ◽  
J. L. A. Fowler
Keyword(s):  
Nervous System ◽  
Gastrointestinal Tract ◽  
Sympathetic Nervous System ◽  
Adrenal Insufficiency ◽  
Adrenal Cortex ◽  
The Other ◽  
Pathological Changes ◽  
Sympathetic Nervous ◽  
Relationship Of ◽  
The Relationship

Five male dogs were adrenalectomized and sympathectomized and maintained by adrenocortical extract for periods of weeks to months. Their general behavior did not differ from those subject to adrenalectomy alone, but in three it was observed that the hair grew long and curly. In the other two a lesser change may have been missed. Following withdrawal of the hormone, death occurred rather suddenly in three, and adrenal insufficiency developed sooner in the other two than in dogs only adrenalectomized. Pathological changes in the gastrointestinal tract were qualitatively the same following death after hormone withdrawal in the adrenalectomized–sympathectomized animals and in dogs only adrenalectomized. Blood changes appeared to be no different in the two groups. The urinary changes with respect to water and electrolytes differed in that the sympathectomized group appeared to take in less water and excrete less urine, but to put out more sodium and chloride, in the few days following withdrawal of hormone. These findings are discussed in particular with respect to the relationship of adrenergic function of the sympathetic nervous system and hormones of the adrenal cortex.

FLUID, ELECTROLYTE, GASTROINTESTINAL, AND HAIR CHANGES IN ADRENALECTOMIZED-SYMPATHECTOMIZED DOGS

1957 ◽  
Vol 35 (1) ◽  
pp. 983-992
Author(s):  
R. A. Cleghorn ◽  
J. L. A. Fowler
Keyword(s):  
Nervous System ◽  
Gastrointestinal Tract ◽  
Sympathetic Nervous System ◽  
Adrenal Insufficiency ◽  
Adrenal Cortex ◽  
The Other ◽  
Pathological Changes ◽  
Sympathetic Nervous ◽  
Relationship Of ◽  
The Relationship

Five male dogs were adrenalectomized and sympathectomized and maintained by adrenocortical extract for periods of weeks to months. Their general behavior did not differ from those subject to adrenalectomy alone, but in three it was observed that the hair grew long and curly. In the other two a lesser change may have been missed. Following withdrawal of the hormone, death occurred rather suddenly in three, and adrenal insufficiency developed sooner in the other two than in dogs only adrenalectomized. Pathological changes in the gastrointestinal tract were qualitatively the same following death after hormone withdrawal in the adrenalectomized–sympathectomized animals and in dogs only adrenalectomized. Blood changes appeared to be no different in the two groups. The urinary changes with respect to water and electrolytes differed in that the sympathectomized group appeared to take in less water and excrete less urine, but to put out more sodium and chloride, in the few days following withdrawal of hormone. These findings are discussed in particular with respect to the relationship of adrenergic function of the sympathetic nervous system and hormones of the adrenal cortex.

scholarly journals Dr. A. I. Yushchenko. The relationship of the lower mesenteric sympathetic node to the innervation of the bladder and the volume of automatic movements of the last day. - Archive of Biological Sciences, T. VI, issue 5

2020 ◽  
Vol VI (4) ◽  
pp. 213-214
Author(s):  
B. I. Vorotynskiy
Keyword(s):  
Biological Sciences ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Morphological Properties ◽  
The Central Nervous System ◽  
Sympathetic Nervous ◽  
The Right ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain

Physiology has not yet given us positive data on the function of the sympathetic nervous system. Only recently, histologists have been able to prove that the nerve cells located in large sympathetic nodes do not differ in their morphological properties from cells of the central nervous system. This gives the right to assume that in the sympathetic nodes there are independent centers that are in the same dependence on the higher centers, as, for example, the centers of the spinal cord from the brain. We have very little data on the relationship of the sympathetic nervous system to the innervations of the bladder. On this basis, the author began to study this issue in the physiological laboratory of prof. Pavlova at the M. Academy.

Sympathetic regulation of cerebral blood flow during seizures in newborn lambs

1988 ◽  
Vol 255 (3) ◽  
pp. H563-H568
Author(s):  
C. D. Kurth ◽  
L. C. Wagerle ◽  
M. Delivoria-Papadopoulos
Keyword(s):  
Blood Flow ◽  
Nervous System ◽  
Cerebral Blood Flow ◽  
Sympathetic Nervous System ◽  
Sympathetic Nerves ◽  
The Other ◽  
Cerebral White Matter ◽  
Blood Flows ◽  
Sympathetic Regulation ◽  
Sympathetic Nervous

We examined cerebral blood flow (CBF) regulation by the sympathetic nerves in 12 newborn lambs (3–11 days old) during seizures, a potent reflex stimulator of the sympathetic nervous system. CBF was measured with microspheres, and seizures were induced with bicuculline. In six of these lambs, one hemibrain was denervated (D) chronically by interrupting the ipsilateral cervical sympathetic trunk; the other hemibrain remained innervated (I). Before and after 10, 35, and 70 min of seizures, cerebral gray matter blood flow (mean +/- SE ml.min-1.100 g-1) was, respectively, 12 +/- 3 (9%), 71 +/- 12 (21%), 120 +/- 15 (38%), and 54 +/- 5 (14%) greater (P less than 0.05) in the D than in the I hemibrain. In the cerebral white matter, hippocampus, caudate, and thalamus blood flows to the D and I hemibrains were similar before seizures but during seizures they were 10–39% greater (P less than 0.05) in the D than in the I hemibrain. Midbrain, brainstem, and cerebellum D and I blood flows were always similar. In the other six lambs, acute denervation during seizures increased ipsilateral cerebral gray and hippocampus blood flow by 10–31%, but unilateral electrical stimulation decreased ipsilateral cerebral gray, cerebral white, hippocampus, thalamus, and caudate blood flow by 17–27%. The data demonstrate that, during seizures, sympathetic nerve activity modifies regional CBF and the effect is sustained, suggesting a role for the sympathetic nervous system in newborn CBF regulation.

METABOLISM OF OESTRIOL-3-SULPHATE-16-GLUCOSIDURONATE IN PREGNANT WOMEN

1968 ◽  
Vol 59 (4) ◽  
pp. 595-610 ◽  
Author(s):  
U. Goebelsmann ◽  
N. Wiqvist ◽  
E. Diczfalusy
Keyword(s):  
Gastrointestinal Tract ◽  
Urinary Excretion ◽  
General Scheme ◽  
Urinary Metabolites ◽  
The Other ◽  
Missed Abortion ◽  
Pregnancy Urine ◽  
Relationship Of ◽  
The Relationship ◽  
Important Constituent

ABSTRACT A combination of 3H-labelled oestriol-3-sulphate-16-glucosiduronate (OE3-3S,16Gl) and 14C-labelled oestriol-16-glucosiduronate (OE3-16Gl) was infused over a 6 hour period to one woman at midpregnancy and to another woman with missed abortion in the 4th month of gestation. The urinary metabolites were isolated and identified. Sixty-four per cent of the 3H- and about 80 % of the 14C-labelled material was excreted in the urine within 24 hours. Some 20 % of the 3H-labelled, but only 2–3 % of the 14C-labelled material recovered was OE3-3S,16Gl. Approximately one half of the 3H-, but less than one-third of the 14C-labelled material was oestriol-3-glucosiduronate (OE3-3Gl). On the other hand, more than two-thirds of the 14C-labelled material, but less than one-third of the 3H-labelled was OE3-16Gl. The urinary elimination of OE3-3S,16Gl was much slower than that of OE3-16Gl and resembled closely the behaviour of oestriol-3-sulphate (OE3-3S) in this respect. The amounts of endogenous OE3-3S,16Gl and OE3-16Gl reaching the circulation each hour were calculated from their urinary excretion and from the relationship of infused and excreted labelled OE3-3S,16Gl and OE3-16Gl. On the basis of these estimates it is concluded that OE3-3S,16Gl is a quantitatively important constituent of pregnancy plasma, but not of pregnancy urine. It is suggested that OE3-3S,16Gl is formed mainly, if not entirely from OE3-16Gl, most probably in the liver and perhaps also in the gastrointestinal tract. A general scheme is presented, describing the over-all metabolism of conjugated oestriol.

L-Dopa metabolism in genetically hypertensive mice: effect of pargyline

1987 ◽  
Vol 65 (12) ◽  
pp. 2390-2395 ◽  
Author(s):  
Nguyen T. Buu ◽  
Johanne Duhaime ◽  
Karoly Racz ◽  
Otto Kuchel ◽  
Gunther Schlager
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Monoamine Oxidase ◽  
Hydroxylase Activity ◽  
Sympathetic Nervous ◽  
The Relationship ◽  
The Brain ◽  
Genetically Hypertensive

This study on the role of the sympathetic nervous system in the development of hypertension involves the measurement of dopamine and norepinephrine accumulation in various tissues of the hypertensive and random-bred normotensive strains of mice at basal levels, and following a pargyline–L-dopa treatment. Under such a treatment, designed to suppress the homeostatic action of monoamine oxidase and to better expose the relationship between dopamine and norepinephrine, the brain and heart of the hypertensive mice accumulated more dopamine than the normotensive mice. There was a significantly lower norepinephrine accumulation in the heart of the hypertensive mice in spite of comparable dopamine-β-hydroxylase activity in this tissue between the two strains of mice. Under the pargyline–L-dopa treatment, the brain and heart of the older mice in both hypertensive and normotensive strains accumulated significantly (p < 0.05) more dopamine than those of their younger counterparts, while their norepinephrine accumulation remained unchanged. The results demonstrated different patterns of response of dopamine and norepinephrine in the development of hypertension.

Sympathetic nervous system plays an important role in the relationship between immune mediated diseases

2006 ◽  
Vol 67 (4) ◽  
pp. 900-903 ◽  
Author(s):  
Shahram Shahabi ◽  
Zuhair Muhammad Hassan ◽  
Nima Hosseini Jazani ◽  
Massoumeh Ebtekar
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Immune Mediated ◽  
Sympathetic Nervous ◽  
The Relationship
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