SYNTHESIS OF PHOSPHOLIPID METABOLITES: L-α-GLYCERYLPHOSPHORYL-2-AMINO-2-METHYLPROPANOL
1964 ◽
Vol 42
(11)
◽
pp. 1547-1551
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Keyword(s):
A constituent of and possible intermediate in the metabolism of phosphatidyl-2-amino-2-methylpropanols has been synthesized. The fatty-acid-free moiety, i.e. L-α-glycerylphosphoryl-2-amino-2-methylpropanol, was obtained by phosphorylating D-acetone glycerol with phosphorus oxychloride and quinoline, esterifying the acetone L-α-glycerylphosphoric acid dichloride with N-carbobenzoxy-2-amino-2-methylpropanol in the presence of pyridine, removing the acetone group of acetone L-α-glycerylphosphoryl-N-carbobenzoxy-2-amino-2-methylpropanol by mild acid hydrolysis, and freeing the barium salt of L-α-glycerylphosphoryl-N-carbobenzoxy-2-amino-2-methylpropanol from its protective carbobenzoxy group by catalytic hydrogenolysis.
1958 ◽
Vol 36
(2)
◽
pp. 243-248
◽
Keyword(s):
Keyword(s):
1958 ◽
Vol 36
(1)
◽
pp. 243-248
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Keyword(s):
1989 ◽
Vol 54
(3)
◽
pp. 803-810
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Keyword(s):
Keyword(s):
1984 ◽
Vol 93
(3)
◽
pp. 219-234
1984 ◽
Vol 93
(3)
◽
pp. 197-218