Reaction on a solid surface — A simple, economical, and efficient Mannich reaction of azacrown ethers over graphite

2008 ◽  
Vol 86 (5) ◽  
pp. 426-434 ◽  
Author(s):  
Hashem Sharghi ◽  
Reza Khalifeh
Keyword(s):  
Phenolic Compounds ◽  
Solid Surface ◽  
Mannich Reaction ◽  
Graphite Powder ◽  
Solvent Free ◽  
Azacrown Ether ◽  
Azacrown Ethers ◽  
Lariat Ether ◽  
Solvent Free Conditions

Graphite brings about a rapid Mannich reaction with a range of activated and unactivated phenolic compounds such as p-cresol and p-nitrophenol. The reactions are carried out with azacrown ether and paraformaldehyde in solvent-free conditions at 100 °C for 20–30 min. The graphite powder can be reused up to three times after simple washing with acetone.Key words: azacrown ether, lariat ether, graphite, solvent-free, Mannich reaction.

ChemInform Abstract: Direct Mannich Reaction Mediated by Fe(Cp)2PF6under Solvent-Free Conditions.

ChemInform ◽  
2010 ◽  
Vol 41 (16) ◽  
Author(s):  
Rukhsana I. Kureshy ◽  
Santosh Agrawal ◽  
S. Saravanan ◽  
Noor-ul H. Khan ◽  
Arpan K. Shah ◽  
...  
Keyword(s):  
Mannich Reaction ◽  
Solvent Free ◽  
Solvent Free Conditions

Diaryliodonium salts as efficient Lewis acid catalysts for direct three component Mannich reactions

RSC Advances ◽  
2015 ◽  
Vol 5 (32) ◽  
pp. 25485-25488 ◽  
Author(s):  
Yanxia Zhang ◽  
Jianwei Han ◽  
Zhen-Jiang Liu
Keyword(s):  
Lewis Acid ◽  
Mannich Reaction ◽  
Solvent Free ◽  
Acid Catalysts ◽  
Lewis Acid Catalysts ◽  
Mannich Reactions ◽  
Highly Active ◽  
Diaryliodonium Salts ◽  
Solvent Free Conditions

Diaryliodonium(iii) salts, as highly active and versatile Lewis acid catalysts for the direct three component Mannich reaction under solvent free conditions, have been investigated.

The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

2003 ◽  
Vol 5 (4) ◽  
pp. 477-479 ◽  
Author(s):  
L. El Kaïm ◽  
L. Gautier ◽  
L. Grimaud ◽  
L. M. Harwood ◽  
V. Michaut
Keyword(s):  
Mannich Reaction ◽  
Solvent Free ◽  
Solvent Free Conditions ◽  
The Mannich Reaction

scholarly journals Hf(OTf)4 as a Highly Potent Catalyst for the Synthesis of Mannich Bases under Solvent-Free Conditions

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 388 ◽  
Author(s):  
Shuai-Bo Han ◽  
Jing-Ying Wei ◽  
Xiao-Chong Peng ◽  
Rong Liu ◽  
Shan-Shan Gong ◽  
...  
Keyword(s):  
Exchange Reaction ◽  
1H Nmr ◽  
Mannich Reaction ◽  
Reaction Rate ◽  
Mannich Bases ◽  
Solvent Free ◽  
Solvent Free Conditions

Hf(OTf)4 was identified as a highly potent catalyst (0.1–0.5 mol%) for three-component Mannich reaction under solvent-free conditions. Hf(OTf)4-catalyzed Mannich reaction exhibited excellent regioselectivity and diastereoselectivity when alkyl ketones were employed as substrates. 1H NMR tracing of the H/D exchange reaction of ketones in MeOH-d4 indicated that Hf(OTf)4 could significantly promote the keto-enol tautomerization, thereby contributing to the acceleration of reaction rate.

scholarly journals One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5065 ◽  
Author(s):  
Giovanna Bosica ◽  
Ramon Zammit
Keyword(s):  
Heterogeneous Catalyst ◽  
Mannich Reaction ◽  
Reaction Times ◽  
Solvent Free ◽  
Free Medium ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Activity Loss ◽  
A Minor ◽  
Minor Activity

An environmentally-friendly, one-pot multicomponent reaction of various aldehydes, amines and nitroalkanes for the synthesis of β-nitroamines is here described. Amberlyst A-21 supported CuI was found to be a highly efficient novel heterogeneous catalyst for the three-component nitro-Mannich reaction between aldehydes, amines and nitroalkanes. The developed protocol is performed in a solvent-free medium to produce a variety of β-nitroamines in good to excellent yields within short reaction times. The catalyst can be easily prepared and recovered. It has been tested up to eight times with only a minor activity loss.

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