A new stereospecific total synthesis of chasmanine and 13-desoxydelphonine

1978 ◽  
Vol 56 (10) ◽  
pp. 1451-1454 ◽  
Author(s):  
Karel Wiesner ◽  
Thomas Y. R. Tsai ◽  
Krishnan P. Nambiar
Keyword(s):  
Total Synthesis ◽  
Vinyl Ether ◽  
Simple Synthesis ◽  
Photochemical Synthesis ◽  
New Process ◽  
Order Of Magnitude

A simple synthesis of the title compounds, which is more than 10 steps shorter and an order of magnitude more efficient than our recent photochemical synthesis of chasmanine, is described. The main feature of the new process is a stereo- and regiospecific addition of benzyl vinyl ether to an o-quinone intermediate masked by a spirolactone group according to the method of Deslongchamps.

Simple Synthesis of Racemic Pyrrolo[2,3-b]indoles: Formal Total Synthesis of (.+-.)-Physostigmine.

ChemInform ◽  
2003 ◽  
Vol 34 (12) ◽  
Author(s):  
Riichiro Tsuji ◽  
Masako Nakagawa ◽  
Atsushi Nishida
Keyword(s):  
Total Synthesis ◽  
Simple Synthesis

A new process for enhancing conversion of methyl vinyl ether to propylene yields with Al2O3 hollow spheres

RSC Advances ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 8736-8742 ◽  
Author(s):  
Yang Wang ◽  
Wenyu Zhang ◽  
Daoan Zha ◽  
Jiaji Hu ◽  
Wei Li ◽  
...  
Keyword(s):  
Vinyl Ether ◽  
Hollow Spheres ◽  
Methyl Vinyl ◽  
New Process ◽  
Methyl Vinyl Ether

The proposed mechanism for a new process to convert methyl vinyl ether to propylene.

ChemInform Abstract: Stereospecific Photochemical Synthesis of cis- and trans- Hexahydrocarbazol-4-ones: Useful Synthons for the Total Synthesis of Aspidosperma Alkaloids

ChemInform ◽  
2010 ◽  
Vol 28 (15) ◽  
pp. no-no
Author(s):  
Y. TROIN ◽  
M.-E. SINIBALDI ◽  
D. GARDETTE ◽  
D. DUGAT ◽  
M. DUFOUR ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Photochemical Synthesis ◽  
Cis And Trans

Aflatoxin B1 Hemiacetal

1968 ◽  
Vol 51 (4) ◽  
pp. 907-910 ◽  
Author(s):  
A E Borland ◽  
Mary E Cushmac ◽  
P J Andrellos
Keyword(s):  
Double Bond ◽  
Chick Embryo ◽  
Total Synthesis ◽  
Vinyl Ether ◽  
Aflatoxin B1 ◽  
Lethal Dose ◽  
Tissue Cultures ◽  
Acid Catalyzed ◽  
Minimum Lethal Dose

Abstract The acid-catalyzed addition of water to the vinyl ether double bond of aflatoxin Bx was investigated. The hemiacetal produced was biologically inactive to the chick embryo and to tissue cultures at respective concentrations 80 and 50 times the minimum lethal dose of aflatoxin B1 The structure of the hemiacetal was established and found to be identical to the hemiacetal reported as an intermediate in the total synthesis of racemic aflatoxin B1

Simple Synthesis of Racemic Pyrrolo[2,3-b]indoles: Formal Total Synthesis of (±)-Physostigmine

Heterocycles ◽  
2002 ◽  
Vol 58 (1) ◽  
pp. 587 ◽  
Author(s):  
Atsushi Nishida ◽  
Riichiro Tsuji ◽  
Masako Nakagawa
Keyword(s):  
Total Synthesis ◽  
Simple Synthesis

scholarly journals LPMX: A pure rootless composable container system

2021 ◽  
Author(s):  
Xu Yang ◽  
Masahiro Kasahara
Keyword(s):  
Genome Analysis ◽  
Genome Research ◽  
New Process ◽  
Order Of Magnitude

Delivering tools for genome analysis to users is often difficult given their complex dependencies and conflicts. Container virtualization systems such as Singularity isolate environments, helping developers avoid conflicts between tools. However, they lack composability, an easy way to integrate multiple tools in different containers or multiple tools both in a container and a host, which compromises the use of container systems in genome research. Another issue is that one may not be able to use a single container system of the same version at all sites they use, which discourages the use of container systems. To this end, we present a pure rootless composable container system, LPMX, that provides composability for letting developers easily integrate tools in different existing containers or on host, allowing researchers to compose existing containers. LPMX is pure rootless, so it does not require root privilege neither during installation nor at runtime, allowing researchers to use LPMX across sites without asking permissions from administrators. LPMX provides a pure userspace layered filesystem with at least an order of magnitude lower overhead for launching a new process than existing container systems. LPMX can import Docker and Singularity images.

scholarly journals Direct Synthesis of Unprotected 2-Azidoamines from Alkenes via an Iron-Catalyzed Difunctionalization Reaction

2020 ◽  
Author(s):  
Szabolcs Makai ◽  
Eric Falk ◽  
Bill Morandi
Keyword(s):  
Total Synthesis ◽  
Functional Group ◽  
Direct Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Simple Synthesis ◽  
Active Compounds ◽  
Complex Drug ◽  
Vicinal Diamines

<div> <p>Unprotected, primary 2-azidoamines are versatile precursors to vicinal diamines, which are among the most common motifs in biologically active compounds. Herein, we report their operationally simple synthesis through an iron-catalyzed difunctionalization of alkenes. A wide array of alkene substrates are tolerated, including complex drug-like molecules and a tripeptide. Facile derivatizations of the azidoamine group demonstrate the versatility of this masked diamine motif in chemoselective, orthogonal transformations. Applications of the methodology in the concise synthesis of RO 20-1724 and in a formal total synthesis of (±)-hamacanthin B further demonstrate the broad synthetic potential of this highly functional group tolerant reaction.</p> </div>

Catalyst-controlled stereoselective cationic polymerization of vinyl ethers

Science ◽  
2019 ◽  
Vol 363 (6434) ◽  
pp. 1439-1443 ◽  
Author(s):  
A. J. Teator ◽  
F. A. Leibfarth
Keyword(s):  
Physical Properties ◽  
Tensile Properties ◽  
Vinyl Ether ◽  
Cationic Polymerization ◽  
Vinyl Monomers ◽  
Next Generation ◽  
Vinyl Ethers ◽  
Engineering Applications ◽  
Vinyl Polymers ◽  
Order Of Magnitude

The tacticity of vinyl polymers has a profound effect on their physical properties. Despite the well-developed stereoselective methods for the polymerization of propylene and other nonpolar α-olefins, stereoselective polymerization of polar vinyl monomers has proven more challenging. We have designed chiral counterions that systematically bias the reactivity and chain-end stereochemical environment during cationic polymerization. This approach overrides conventional chain-end stereochemical bias to achieve catalyst-controlled stereoselective polymerization. We demonstrate that this method is general to vinyl ether substrates, providing access to a range of isotactic poly(vinyl ether)s with high degrees of isotacticity. The obtained materials display the tensile properties of commercial polyolefins but adhere more strongly to polar substrates by an order of magnitude, indicating their promise for next-generation engineering applications.

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