Platinum(II) and magnesium(II) nucleotide complexes. Synthesis, FT-ir spectra, and structural properties

1983 ◽  
Vol 61 (8) ◽  
pp. 1813-1822 ◽  
Author(s):  
H. A. Tajmir-Riahi ◽  
T. Theophanides
Keyword(s):  
Water Molecule ◽  
Ir Spectra ◽  
Metal Ions ◽  
Structural Properties ◽  
Acidic Solution ◽  
Neutral Solution ◽  
Metal Bonding ◽  
Ft Ir ◽  
Cis And Trans ◽  
Chemical Evidence

Guanosine-5′-monophosphate (5′-GMP) reacts with Pt(II) and Mg(II) metal ions to give complexes of the type Pt(5′-GMP)nCl2•xH2O, cis- and trans-[Pt(NH3)2(5′-GMP)2]Cl2•xH2O and Mg(5'-GMP2)•xH2O, where n = 1, 2, 3, 4 and x = 4–10.Spectroscopic and chemical evidence showed marked similarities with those of the structurally known N7-bonded 5′-GMP complexes of Mn(II), Co(II), Ni(II), Cu(II), and Cd(II) metal ions. Therefore, Pt(II) and Mg(II) are also found to be N7-bonded in these series of nucleotide complexes.The direct phosphate coordination was observed in Mg(II) nucleotide complexes obtained from acidic solution, whereas Mg(II) complexes prepared from neutral solution showed no direct phosphate–Mg(II) interaction. Pt(II) complexes exhibited no direct phosphate metal bonding, while the possibility of an indirect Pt(II)–phosphate interaction through a hydrogen-bonded water molecule can be proposed here.

Vibrational spectra of solid cis- and trans-2-thioxohexahydroquinazolin-4(1H)-one and theoretical calculations towards the interpretation of its thermal reactivity

RSC Advances ◽  
2015 ◽  
Vol 5 (54) ◽  
pp. 43345-43352 ◽  
Author(s):  
A. G. Iriarte ◽  
W. J. Peláez ◽  
F. Fülöp ◽  
G. A. Argüello
Keyword(s):  
Ir Spectra ◽  
Vibrational Spectra ◽  
Solid Phase ◽  
Theoretical Calculations ◽  
Thermal Reactivity ◽  
Ft Ir ◽  
Cis And Trans ◽  
Ft Raman

FT-Raman and FT-IR spectra ofcisandtrans2-thioxohexahydroquinazolin-4(1H)-one are reported. Both compounds are dimers in the solid phase, withC2symmetry. This work contributes to the knowledge of data which are rather scarce for quinazolinones.

Classification of Vegetable Oils by FT-IR

1997 ◽  
Vol 51 (8) ◽  
pp. 1118-1124 ◽  
Author(s):  
Donald B. Dahlberg ◽  
Shawn M. Lee ◽  
Seth J. Wenger ◽  
Julie A. Vargo
Keyword(s):  
Ir Spectra ◽  
Principal Component ◽  
Fast Detection ◽  
Signal Correction ◽  
Ft Ir ◽  
Ir Detection ◽  
The Fourier Transform ◽  
Cooking Oils ◽  
Cis And Trans

The Fourier transform infrared (FT-IR) spectra of 27 brands of 10 types of cooking oils and margarines were measured without temperature control. Attempts to predict the vegetable source and physical properties of these oils failed until wavelength selection and multiplicative signal correction (MSC) were applied to the FT-IR spectra. After pretreatment of the data, principal component analysis (PCA) was totally successful at oil identification, and partial least-squares (PLS) models were able to predict both the refractive indices [standard error of estimation (SEE) 0.0002] and the viscosities (SEE 0.52 cP) of the oils. These models were based predominately on the FT-IR detection of the cis and trans double-bond content of the oils, as well as small amounts of defining impurities in sesame oils. Efforts to use selected wavelengths to discriminate oil sources were only partially successful. These results show the potential utility of FT-IR in the fast detection of substitution or adulteration of products like cooking oils.

FT-IR microspectroscopic analysis of diseased white matter brain tissues

1995 ◽  
Vol 53 ◽  
pp. 968-969
Author(s):  
Steven M. Le Vine ◽  
David L. Wetzel
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
Twitcher Mouse ◽  
Grid Pattern ◽  
Marked Contrast ◽  
Spatially Resolved ◽  
Ft Ir ◽  
Ir Microspectroscopy ◽  
Chemical Evidence

In situ FT-IR microspectroscopy has allowed spatially resolved interrogation of different parts of brain tissue. In previous work the spectrrscopic features of normal barin tissue were characterized. The white matter, gray matter and basal ganglia were mapped from appropriate peak area measurements from spectra obtained in a grid pattern. Bands prevalent in white matter were mostly associated with the lipid. These included 2927 and 1469 cm-1 due to CH2 as well as carbonyl at 1740 cm-1. Also 1235 and 1085 cm-1 due to phospholipid and galactocerebroside, respectively (Figs 1and2). Localized chemical changes in the white matter as a result of white matter diseases have been studied. This involved the documentation of localized chemical evidence of demyelination in shiverer mice in which the spectra of white matter lacked the marked contrast between it and gray matter exhibited in the white matter of normal mice (Fig. 3).The twitcher mouse, a model of Krabbe’s desease, was also studied. The purpose in this case was to look for a localized build-up of psychosine in the white matter caused by deficiencies in the enzyme responsible for its breakdown under normal conditions.

Clinical Evaluation of Radio-Labelled Bleomycin for Tumor Detection

1978 ◽  
Vol 17 (06) ◽  
pp. 238-248
Author(s):  
H. Beekhuis ◽  
M.A.P.C. van de Poll ◽  
A. Versluis ◽  
H. Jurjens ◽  
M.G. Woldring ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Acidic Solution ◽  
Tumor Detection ◽  
Neutral Solution ◽  
Normal Tissues ◽  
Patients With Cancer ◽  
Tumor Bearing

Investigations with bleomycin labelled with radionuclides other than 57Co in patients with cancer and in tumor-bearing animals are described. In patients 57Co-bleo appears to be a better tumor-seeking radiopharmaceutical than 111In-bleo, 99mTc-bleo or 197Hg-bleo. This can be explained by a higher stability in vivo and a better tumor-seeking property of 57Co-bleo and less disturbing activity in the cardiac pool and in bone and other normal tissues when assessing the scintigram.Results with 111In-bleo labelled in acidic solution are not essentially different from those with 111In-bleo labelled in neutral solution.Results of 197Hg-bleo are almost identical with those of 197HgCl2 regarding the tumor-seeking effect as well as the distribution in normal tissues and organs. Probably the complex of 197Hg to bleomycin is not stable in vivo. The superiority of 57Co-bleo over 99mTc-bleo, 197Hg-bleo and also over 67Cu-bleo is confirmed by experiments on tumor bearing animals.We may conclude that the indication for use of bleomycin as a tumor-seeking pharmaceutical labelled with 111In, 99mTc, 197Hg or 67Cu seems to be very limited.

Light- or Dark-Colored, L-DOPA-Based Melanins

2018 ◽  
Author(s):  
Koen Vercruysse ◽  
Margaret M. Whalen
Keyword(s):  
Human Physiology ◽  
Ir Spectra ◽  
Immune Cells ◽  
Chemical Properties ◽  
Chemical Signature ◽  
Ft Ir

<p>This report is a continuation of previous research on the H<sub>2</sub>O<sub>2</sub>-mediated synthesis of melanin-like pigments. We synthesized and characterized L-DOPA-based pigments using air- or H<sub>2</sub>O<sub>2</sub>-mediated<sub> </sub>oxidation. We compared their physic-chemical properties and evaluated their capacity to affect the interleukin release from immune cells. The use of higher concentrations of H<sub>2</sub>O<sub>2</sub> resulted in melanin-like materials with a distinct chemical signature in their FT-IR spectra and a lighter color. All pigments enhanced the interleukin release from immune cells. The possibility that lighter-colored melanins can be generated is discussed in the context of the importance of melanin-based pigmentation in human physiology.</p>

scholarly journals Spectroscopy as a useful tool for the identification of changes with time in post-mortem vitreous humor for forensic toxicology purposes

2021 ◽  
Author(s):  
Anna Wójtowicz ◽  
Agata Mitura ◽  
Renata Wietecha-Posłuszny ◽  
Rafał Kurczab ◽  
Marcin Zawadzki
Keyword(s):  
Ir Spectra ◽  
Forensic Toxicology ◽  
Principal Component ◽  
Hierarchical Cluster ◽  
Vitreous Humor ◽  
Attenuated Total Reflection ◽  
Glass Slides ◽  
Added Benefit ◽  
Ft Ir ◽  
Non Destructive

AbstractVitreous humor (VH) is an alternative biological matrix with a great advantage of longer availability for analysis due to the lack of many enzymes. The use of VH in forensic toxicology may have an added benefit, however, this application requires rapid, simple, non-destructive, and relatively portable analytical analysis methods. These requirements may be met by Fourier transform infrared spectroscopy technique (FT-IR) equipped with attenuated total reflection accessory (ATR). FT-IR spectra of vitreous humor samples, deposited on glass slides, were collected and subsequent chemometric data analysis by means of Hierarchical Cluster Analysis and Principal Component Analysis was conducted. Differences between animal and human VH samples and human VH samples stored for diverse periods of time were detected. A kinetic study of changes in the VH composition up to 2 weeks showed the distinction of FT-IR spectra collected on the 1st and 14th day of storage. In addition, data obtained for the most recent human vitreous humor samples—collected 3 and 2 years before the study, presented successful discrimination of all time points studied. The method introduced was unable to detect mephedrone addition to VH in the concentration of 10 µg/cm3. Graphic abstract

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