Thionium analogs of the opiates levorphanol and isolevorphanol: synthesis of the 17-deaza-17-thia isosteres (sulforphanol and isosulforphanol)
Keyword(s):
The total synthesis of the position-17 sulfur analogs of the perchlorate salts of the morphinans, (±)-levorphanol and (±)-isolevorphanol via4a-(2-aminoethyl)-1,2,3,4,4a,9-hexahydro-6-methoxyphenanthrene, a key intermediate in the synthesis of butorphanol (4), is described. 2D-Correlation and heterocorrelation nuclear magnetic resonance spectroscopy confirmed the configurational relationship of the isosteres.
2010 ◽
pp. 1-7
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2013 ◽
Vol 40
(12)
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pp. 1933-1937
1981 ◽
Vol 640
(3)
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pp. 727-733
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1975 ◽
Vol 250
(13)
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pp. 4986-4991