1-ChIoromethyl-3,5-dimethylpyrazole hydrochloride. A useful synthetic intermediate

1989 ◽  
Vol 67 (7) ◽  
pp. 1144-1147 ◽  
Author(s):  
Alan R. Katritzky ◽  
Jamshed N. Lam
Keyword(s):  
Carbonyl Compounds ◽  
Alkyl Halides ◽  
Nucleophilic Displacement ◽  
Novel Method ◽  
Synthetic Intermediate ◽  
Substituted Pyrazoles

1-Chloromethyl-3,5-dimethylpyrazole hydrochloride readily undergoes nucleophilic displacement with O-, N-, or S-nu-cleophiles. 1-Phenylthiomethyl-3,5-dimethylpyrazole can be lithiated at the CH2 group and reacted with alkyl halides and carbonyl compounds. Desulfurization of the products affords a novel method of preparing N-substituted pyrazoles. Keywords: pyrazole, lithiation, chloromethylazoles, desulfurization.

scholarly journals Copper(I) Chloride/Kieselguhr: A Versatile Catalyst for Oxidation of Alkyl Halides and Alkyl Tosylates to the Carbonyl Compounds

1999 ◽  
Vol 23 (7) ◽  
pp. 434-435
Author(s):  
Mohammed M. Hashemi ◽  
Yousef Ahmadi Beni
Keyword(s):  
Carbonyl Compounds ◽  
Alkyl Halides ◽  
Aldehydes And Ketones ◽  
High Yields

Copper(I) Chloride adsorbed on Kieselguhr in the presence of oxygen catalyses oxidation of alkyl halides and alkyl tosylates to the aldehydes and ketones in high yields.

A Novel Method for N3-Functionalized Aminoimidazolines and Aminopyrimidines by Aza-Michael Additions of Aminoimidazolines and Aminopyrimidines to α,β-Unsaturated Carbonyl Compounds

Heterocycles ◽  
2007 ◽  
Vol 71 (11) ◽  
pp. 2363 ◽  
Author(s):  
Xi-Cun Wang ◽  
Cheng-Wei Lv ◽  
Zheng-Jun Quan ◽  
Guo-Li Huang ◽  
Wen-Long Yang
Keyword(s):  
Carbonyl Compounds ◽  
Michael Additions ◽  
Novel Method

scholarly journals Arylation and alkenylation of activated alkyl halides using sulfonamides

2020 ◽  
Vol 56 (21) ◽  
pp. 3222-3224
Author(s):  
Stuart Johnson ◽  
Ervin Kovács ◽  
Michael F. Greaney
Keyword(s):  
Amino Acid ◽  
Carbonyl Compounds ◽  
Alkyl Halides ◽  
Amino Acid Derivatives ◽  
Smiles Rearrangement

A variety of quaternary aryl amino acid derivatives can be synthesised using tandem SN2/Smiles rearrangement chemistry involving aryl sulfonamides and α-chloro carbonyl compounds.

Sodium Selenosulfate from Sodium Sulfite and Selenium Powder: An Odorless Selenylating Reagent for Alkyl Halides to Produce Dialkyl Diselenide Catalysts

Synlett ◽  
2019 ◽  
Vol 30 (14) ◽  
pp. 1698-1702
Author(s):  
Yonghong Liu ◽  
Hai Ling ◽  
Chao Chen ◽  
Qing Xu ◽  
Lei Yu ◽  
...  
Keyword(s):  
Selective Oxidation ◽  
Carbonyl Compounds ◽  
Sodium Sulfite ◽  
Alkyl Halides ◽  
Production Costs ◽  
Synthetic Method ◽  
Practical Applications ◽  
Sodium Selenosulfate ◽  
Villiger Oxidation

Na2SeSO3, which can be generated in situ by the reaction of Na2SO3 with Se power, was found to be an odorless reagent for the selenenylation of alkyl halides to produce dialkyl diselenides. These products have been recently shown to be good catalysts for the Baeyer–Villiger oxidation of carbonyl compounds, for the selective oxidation of alkenes, or for the oxidative deoximation of oximes. By using aqueous EtOH as the solvent and avoiding the generation of a malodourous selenol intermediate, the selenylation reaction with Na2SeSO3 is much more environmentally friendly than conventional methods. Owing to the cheap and abundant starting materials and selenium reagents, our novel synthetic method reduces the production costs of dialkyl diselenides as organoselenium catalysts, thereby advancing practical applications of organoselenium-catalysis technologies.

ChemInform Abstract: A NOVEL METHOD FOR THE OXIDATION OF PRIMARY AND SECONDARY ALCOHOLS TO CARBONYL COMPOUNDS

1975 ◽  
Vol 6 (6) ◽  
pp. no-no
Author(s):  
Y. S. RAO ◽  
R. FILLER
Keyword(s):  
Carbonyl Compounds ◽  
Secondary Alcohols ◽  
Novel Method
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