Biochemical reactions involved in pancreatic enzyme secretion. 2. Inhibitory effects of tetracaine and atropine
1977 ◽
Vol 55
(3)
◽
pp. 639-643
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Keyword(s):
Pancreatic enzyme secretion induced by urecholine or cholecystokinin–pancreozymin (CCK–PZ) is inhibited by tetracaine. If the pancreatic tissue is preincubated with tetracaine then washed out, the subsequent response to CCK–PZ is not affected while that to urecholine is impaired. In contrast with atropine, tetracaine loses its inhibitory potency once secretion has been initiated by urecholine before the addition of the local anaesthetic. Calcium efflux studies have shown that addition of tetracaine in vitro is associated with release of calcium in the incubation medium. This effect on calcium efflux might explain partly the inhibitory action of the drug.
1974 ◽
Vol 52
(2)
◽
pp. 174-182
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1993 ◽
Vol 265
(2)
◽
pp. G251-G257
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Cholecystokinin at physiological levels evokes pancreatic enzyme secretion via a cholinergic pathway
1992 ◽
Vol 263
(1)
◽
pp. G102-G107
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1986 ◽
Vol 888
(3)
◽
pp. 255-262
◽
1977 ◽
Vol 55
(3)
◽
pp. 644-651
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1981 ◽
Vol 240
(2)
◽
pp. G109-G113
1998 ◽
Vol 275
(5)
◽
pp. G957-G963
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