Changes in spine and radius bone density during long-term hormone replacement

1999 ◽  
Vol 77 (7) ◽  
pp. 505-509 ◽  
Author(s):  
Jennifer M Blake ◽  
Eamonn D Ryan ◽  
Lesley F Beaumont ◽  
Colin E Webber
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Low Dose ◽  
Calcium Supplementation ◽  
Hormone Replacement ◽  
Moderate Dose ◽  
Mineral Density ◽  
Bone Mineral Mass ◽  
Mineral Mass

Lumbar spine and mid-radius bone mineral density was measured repeatedly in 48 postmenopausal women who completed 7 years of taking either a 500 mg·day-1 calcium supplement (n = 22) or calcium supplementation with hormone replacement therapy. The hormone replacement was either a low dose (n = 15) or a moderate dose (n = 11) regime. The purpose of the measurements was to establish the long-term pattern of change in bone mineral mass produced by continued hormone replacement. The calcium-only group lost bone mineral mass at the radius, while at the spine, bone was preserved. Low dose hormone replacement preserved radius bone. Moderate dose replacement increased bone mineral mass at the spine and preserved radius bone.Key words: calcium supplementation, long-term hormone replacement, lumbar spine bone mineral density, radius bone mineral density.

Effects of Low-Dose Corticosteroids on the Bone Mineral Density of Patients With Rheumatoid Arthritis

2008 ◽  
Vol 56 (8) ◽  
pp. 1011-1018 ◽  
Author(s):  
Young Ho Lee ◽  
Jin-Hyun Woo ◽  
Seong Jae Choi ◽  
Jong Dae Ji ◽  
Gwan Gyu Song
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Low Dose ◽  
Meta Analysis ◽  
Corticosteroid Treatment ◽  
High Dose ◽  
Mineral Density ◽  
Randomized Controlled Studies

BackgroundThe effects of long-term high-dose corticosteroids on bone mineral density (BMD) are clear, but the effects of low-dose corticosteroids in patients with rheumatoid arthritis (RA) remain controversial. The aim of this study was to assess the effects of low-dose corticosteroids on BMD in patients with RA.MethodsThe authors surveyed randomized controlled studies that examined the effects of low-dose corticosteroids on BMD in patients with RA using MEDLINE and the Cochrane Controlled Trials Register and by performing manual searches. Data were collected on BMD (end-of-period or change-from-baseline) after longest recorded treatment durations. Meta-analysis was performed using a random effects model; outcomes are presented as standardized mean differences (SMDs).ResultsSeven studies were included in this meta-analysis, which included 7 studies on lumbar BMD meta-analysis and 6 studies on femur BMD meta-analysis. Corticosteroids resulted in a moderate worsening in lumbar BMD compared with controls (SMD = −0.483; 95% confidence interval [CI], −0.815 to −0.151, P = 0.004), whereas the femoral BMD differences were not siginificant (SMD = −0.224; 95% CI, −0.663 to 0.215, P = 0.318). Subgroup analysis of BMD data performed on a change-from-baseline basis showed that corticosteroids had a clear effect on both lumbar and femoral BMDs (SMD = −0.354; 95% CI, −0.620 to −0.088, P = 0.009; SMD = −0.488; 95% CI, −0.911 to −0.065, P = 0.024, respectively).ConclusionsThis meta-analysis shows BMD loss after low-dose corticosteroid treatment in patients with RA. These findings have practical implications for the long-term management of patients with RA on low-dose corticosteroids.

scholarly journals Effect of inhaled corticosteroids on bone mineral density in asthmatic children

2021 ◽  
Vol 8 (4) ◽  
pp. 672
Author(s):  
Thanuja Basavanagowda ◽  
Savitha Mysore Ramaraj
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Low Dose ◽  
Inhaled Corticosteroids ◽  
High Dose ◽  
Mineral Density ◽  
Asthmatic Children ◽  
Vitamin D Levels

Background: There is a rise in prevalence of asthma world-over. This study was undertaken as there are controversies regarding the effect of long term inhaled-corticosteroids (ICS) on bone mineral density (BMD).Methods: Asthmatic children belonging to 5-18 year age-group as per the global initiative for asthma guidelines (GINA) guidelines, who were on ICS for a minimum period of 6 months were studied. This study was conducted at a tertiary-care teaching hospital in Mysuru. 60 asthmatic children were compared with 60 non-asthmatic controls. Dual-energy x-ray absorptiometry at 6 sites was used for estimating the BMD and vitamin D levels were measured.Results: 0.771±0.114 g/cm2 was the mean total BMD among children on low dose ICS, while it was 0.613±0.192 and 0.564±0.104 g/cm2 respectively for those on medium and high dose ICS, with p value of 0.026. Children on low dose ICS did not have any impact on BMD, while 18.9% of those on medium and high dose ICS had a reduced total BMD. Trochanteric region was a useful predictor site for monitoring BMD in children on long term ICS with 38.7% and 68.9% being affected when on ICS for 6-12 months and more than 12 months respectively (p=0.018).Conclusions: The ICS of medium and high dose, for a duration of more than 6 months had a reduced total BMD. However, no effect was seen with low dose. Trochanter is a useful site for long term monitoring of BMD in children. There was no correlation between vitamin D levels and control of asthma.

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