Synthesis of new water soluble silicon phthalocyanine substituted by linker sulfur atom and photophysicochemical studies for photodynamic therapy

2021 ◽  
pp. 708-715
Author(s):  
Göknur Yașa Atmaca ◽  
Ali Erdoǧmuș
Keyword(s):  
Photodynamic Therapy ◽  
Sulfur Atom ◽  
Water Soluble ◽  
Soluble Silicon ◽  
Silicon Phthalocyanine

Synthesis of new water soluble silicon phthalocyanine substituted by linker sulfur atom and photophysicochemical studies for photodynamic therapy

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1398-1405 ◽  
Author(s):  
Göknur Yaşa Atmaca ◽  
Ali Erdoğmuş
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Sulfur Atom ◽  
Solvent Effects ◽  
Water Soluble ◽  
Quantum Yields ◽  
Good Solubility ◽  
Silicon Phthalocyanines ◽  
First Time ◽  
Soluble Silicon

In this work, 5-(trifluoromethyl)-2-thiopyridine substituted SiPc (1) and its quaternized derivative (2) were synthesized, and the effect of the linker sulfur atom on silicon phthalocyanines has been investigated for the first time in the literature. Both of the complexes have been characterized by standard spectroscopy methods. The complexes have good solubility in organic solvents and showed monomeric tendencies in all studied solvents. Only complex 2 had some aggregation in water because of solvent effects, as expected. In order to determine the therapeutic effect for cancer treatment, photophysicochemical properties were investigated in DMSO, DMF, toluene and water (for complex 2). The synthesized complexes were found to have about 3.5 times higher singlet oxygen quantum yields than the yields of unsubstituted SiPcCl2 ([Formula: see text] = 0.15 (in DMSO), 0.12 (in DMF), 0.10 (in toluene)) because of the effects of bulky axial groups.

scholarly journals Novel Water-Soluble Silicon(IV) Phthalocyanine for Photodynamic Therapy and Antimicrobial Inactivations

2019 ◽  
Vol 12 (3) ◽  
pp. 255-263 ◽  
Author(s):  
İpek Ömeroğlu ◽  
Meltem Göksel ◽  
Vesselin Kussovski ◽  
Vanya Mantareva ◽  
Mahmut Durmuş
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble ◽  
Soluble Silicon

Preparation and oxygen sensing properties of water-soluble silicon nanoparticles assembled SBA-15

2019 ◽  
Vol 111 ◽  
pp. 1-6 ◽  
Author(s):  
Ting Gong ◽  
Yanjuan Li ◽  
Bingfu Lei ◽  
Jianle Zhuang ◽  
Yingliang Liu ◽  
...  
Keyword(s):  
Silicon Nanoparticles ◽  
Oxygen Sensing ◽  
Water Soluble ◽  
Sensing Properties ◽  
Soluble Silicon

Simple nanophotosensitizer fabrication using water-soluble chitosan for photodynamic therapy in gastrointestinal cancer cells

2017 ◽  
Vol 532 (1) ◽  
pp. 194-203 ◽  
Author(s):  
Young-IL Jeong ◽  
Byungyoul Cha ◽  
Hye Lim Lee ◽  
Yeon Hui Song ◽  
Yun Hye Jung ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Gastrointestinal Cancer ◽  
Water Soluble

Water-soluble dendritic polyaspartic porphyrins: potential photosensitizers for photodynamic therapy

2012 ◽  
Vol 36 (1) ◽  
pp. 28-31 ◽  
Author(s):  
Baoxiang Gao ◽  
Yueling Liu ◽  
Huijuan Yin ◽  
Yingxin Li ◽  
Qianqian Bai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble

Syntheses and properties of acetylene-linked bis- and trisporphyrins toward two-photon photodynamic therapy

2007 ◽  
Vol 11 (06) ◽  
pp. 406-417 ◽  
Author(s):  
Yusuke Inaba ◽  
Kazuya Ogawa ◽  
Yoshiaki Kobuke
Keyword(s):  
Photodynamic Therapy ◽  
Cross Section ◽  
Sodium Salt ◽  
Absorption Cross Section ◽  
Water Soluble ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Photon Irradiation ◽  
Two Photon

Acetylene-bridged bisporphyrins and trisporphyrins having branched bulky bis(carboxylethyl)methyl meso-substituents were synthesized. These compounds showed large effective two-photon absorption cross-section values at 890 nm measured by using a nanosecond Z-scan method. Sodium salt of hydrolyzed trisporphyrins showed broad and red-shifted Q-bands over 900 nm. Two-photon absorption cross-section values of water-soluble dimers in water were similar to, or slightly larger than, those of ester forms evaluated in toluene. Furthermore, the generation of singlet oxygen upon one-photon irradiation for dimers in water was confirmed.

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