MAGNETIC RESONANCE IMAGING OF CARTILAGE REPAIR WITH A FOCUS ON SUBCHONDRAL BONE

2014 ◽  
pp. 305-324
Author(s):  
GREGORY CHANG ◽  
GUILLAUME MADELIN ◽  
DING XIA ◽  
ORRIN SHERMAN ◽  
ERIC STRAUSS ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cartilage Repair ◽  
Subchondral Bone ◽  
Resonance Imaging

Use of magnetic resonance imaging for identifying subchondral bone damage in horses: 11 cases (1999–2003)

2004 ◽  
Vol 224 (3) ◽  
pp. 411-418 ◽  
Author(s):  
Chad J. Zubrod ◽  
Robert K. Schneider ◽  
Russell L. Tucker ◽  
Patrick R. Gavin ◽  
Claude A. Ragle ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Subchondral Bone ◽  
Resonance Imaging ◽  
Bone Damage

scholarly journals Comparison of Bone Marrow Aspirate Concentrate and Allogenic Human Umbilical Cord Blood Derived Mesenchymal Stem Cell Implantation on Chondral Defect of Knee: Assessment of Clinical and Magnetic Resonance Imaging Outcomes at 2-Year Follow-Up

2020 ◽  
Vol 29 ◽  
pp. 096368972094358
Author(s):  
Dong Jin Ryu ◽  
Yoon Sang Jeon ◽  
Jun Sung Park ◽  
Gi Cheol Bae ◽  
Jeong-seok Kim ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Stem Cells ◽  
Bone Marrow ◽  
Magnetic Resonance ◽  
Cartilage Repair ◽  
Bone Marrow Aspirate ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Resonance Imaging

Biological repair of cartilage lesions remains a significant clinical challenge. A wide variety of methods involving mesenchymal stem cells (MSCs) have been introduced. Because of the limitation of the results, most of the treatment methods have not yet been approved by the Food and Drug Administration (FDA). However, bone marrow aspirate concentrate (BMAC) and human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) implantation were approved by Korea FDA. The aim of this study was to evaluate clinical and magnetic resonance imaging (MRI) outcomes after two different types of MSCs implantation in knee osteoarthritis. Fifty-two patients (52 knees) who underwent cartilage repair surgery using the BMAC (25 knees) and hUCB-MSCs (27 knees) were retrospectively evaluated for 2 years after surgery. Clinical outcomes were evaluated according to the score of visual analogue scale (VAS), the International Knee Documentation Committee (IKDC) subjective, and the Knee Injury and Osteoarthritis Outcome Score (KOOS). Cartilage repair was assessed according to the modified Magnetic Resonance Observation of Cartilage Repair Tissue (M-MOCART) score and the International Cartilage Repair Society (ICRS) cartilage repair scoring system. At 2-year follow-up, clinical outcomes including VAS, IKDC, and KOOS significantly improved ( P < 0.05) in both groups; however, there were no differences between two groups. There was no significant difference in M-MOCART [1-year ( P = 0.261), 2-year ( P = 0.351)] and ICRS repair score ( P = 0.655) between two groups. Both groups showed satisfactory clinical and MRI outcomes. Implantation of MSCs from BMAC or hUCB-MSCs is safe and effective for repairing cartilage lesion. However, large cases and a well-controlled prospective design with long-term follow-up studies are needed.

Is Magnetic Resonance Imaging Reliable in Predicting Clinical Outcome After Articular Cartilage Repair of the Knee?

2013 ◽  
Vol 41 (7) ◽  
pp. 1695-1702 ◽  
Author(s):  
Tommy S. de Windt ◽  
Goetz H. Welsch ◽  
Mats Brittberg ◽  
Lucienne A. Vonk ◽  
Stefan Marlovits ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Articular Cartilage ◽  
Magnetic Resonance ◽  
Clinical Outcome ◽  
Cartilage Repair ◽  
Resonance Imaging ◽  
Articular Cartilage Repair

Magnetic resonance imaging of cartilage and cartilage repair

2004 ◽  
Vol 59 (8) ◽  
pp. 674-689 ◽  
Author(s):  
K.L Verstraete ◽  
F Almqvist ◽  
P Verdonk ◽  
G Vanderschueren ◽  
W Huysse ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cartilage Repair ◽  
Resonance Imaging ◽  
And Cartilage

Magnetic Resonance Imaging of Knee Cartilage Repair

1998 ◽  
Vol 9 (6) ◽  
pp. 377???392 ◽  
Author(s):  
Garry E. Gold ◽  
A. Gahrielle Bergman ◽  
John M. Pauly ◽  
Philipp Lang ◽  
R. Kim Butts ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cartilage Repair ◽  
Resonance Imaging ◽  
Knee Cartilage

Articular Cartilage Changes Seen With Magnetic Resonance Imaging-Detected Bone Bruises Associated With Acute Anterior Cruciate Ligament Rupture

1998 ◽  
Vol 26 (3) ◽  
pp. 409-414 ◽  
Author(s):  
Darren L. Johnson ◽  
William P. Urban ◽  
David N. M. Caborn ◽  
William J. Vanarthos ◽  
Cathy S. Carlson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Anterior Cruciate Ligament ◽  
Articular Cartilage ◽  
Magnetic Resonance ◽  
Subchondral Bone ◽  
Cruciate Ligament ◽  
Bone Bruise ◽  
Resonance Imaging ◽  
Bone Bruises ◽  
Anterior Cruciate

Occult osteochondral lesions (bone bruises) have been documented on magnetic resonance images in more than 80% of patients sustaining acute anterior cruciate ligament ruptures. Despite the high prevalence of these lesions, little is known about the histologic changes in the adjacent articular cartilage. Ten patients with acute anterior cruciate ligament ruptures who had a preoperatively documented (by magnetic resonance imaging) geographic bone bruise at the sulcus terminalis on the lateral femoral condyle underwent a 3-mm diameter trephine biopsy of the articular cartilage and subchondral bone overlying the bone bruise at the time of anterior cruciate ligament reconstruction. Biopsy samples of the articular cartilage and subchondral bone were stained with hematoxylin and eosin and toluidine blue. All patients had significant arthroscopic and histologic articular cartilage irregularity in the area overlying the bone bruise. Arthroscopic findings of the articular cartilage included softening (dimpling), fissuring, or overt chondral fracture. Histologic examination revealed degeneration of the chondrocytes and loss of toluidine blue staining in the articular cartilage (loss of proteoglycan). There was necrosis of osteocytes in the subchondral bone, and empty lacuna were visible. This study defines the exact histologic changes of the articular cartilage overlying a geographic bone bruise secondary to an acute anterior cruciate ligament tear. Our findings suggest that a geographic bone bruise found on magnetic resonance imaging indicates substantial damage to normal articular cartilage homeostasis.

Magnetic Resonance Imaging of Articular Cartilage within the Knee

2018 ◽  
Vol 31 (02) ◽  
pp. 155-165 ◽  
Author(s):  
Alissa Burge ◽  
Hollis Potter ◽  
Erin Argentieri
Keyword(s):  
Magnetic Resonance Imaging ◽  
Articular Cartilage ◽  
Magnetic Resonance ◽  
Cartilage Repair ◽  
Quantitative Mri ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Biochemical Assessment ◽  
Insight Into ◽  
Repair Techniques

AbstractMagnetic resonance imaging (MRI) provides an effective and noninvasive means by which to evaluate articular cartilage within the knee. Existing techniques can be utilized to detect and monitor longitudinal changes in cartilage status due to injury or progression of degenerative disease. Quantitative MRI (qMRI) techniques can provide a metric by which to evaluate the efficacy of cartilage repair techniques and offer insight into the composition of cartilage and cartilage repair tissue. In this review, we provide background on MR signal generation and decay, the utility of morphologic MRI assessment, and qMRI techniques for the biochemical assessment of cartilage (dGEMRIC, T2, T2*, T1ρ, sodium, gagCEST). Finally, the description and utility of these qMRI techniques for the evaluation of cartilage repair are discussed.

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