Anti-Inflammatory and Anti-Allergic Effect of Agaricus blazei Extract in Bone Marrow-Derived Mast Cells
2012 ◽
Vol 40
(05)
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pp. 1073-1084
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Keyword(s):
In this study, the anti-inflammatory and anti-allergic effects of the chloroform-soluble extract of Agaricus blazei in mouse bone marrow-derived mast cells (BMMCs) were investigated. The chloroform-soluble extract inhibited IL-6 production in PMA plus A23187-stimulated BMMCs, and down-regulated the phosphorylation of Akt. In addition, this extract demonstrated inhibition of the degranulation of β-hexosaminidase and the production of IL-6, prostaglandin D2 and leukotriene C4 in PMA plus A23187-induced BMMCs. In conclusion, the chloroform-soluble extract of Agaricus blazei exerted anti-inflammatory and anti-allergic activities mediated by influencing IL-6, prostaglandin D2, leukotriene C4, and the phosphorylation of Akt.
2011 ◽
Vol 33
(4)
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pp. 709-713
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Keyword(s):
2011 ◽
Vol 34
(2)
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pp. 250-255
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2012 ◽
Vol 34
(4)
◽
pp. 639-644
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2011 ◽
Vol 34
(9)
◽
pp. 1495-1501
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Keyword(s):
Keyword(s):
1996 ◽
Vol 271
(42)
◽
pp. 25936-25944
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1995 ◽
Vol 182
(1)
◽
pp. 197-206
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Keyword(s):