EFFECT OF LOADING RATE ON VISCOELASTIC PROPERTIES AND LOCAL MECHANICAL HETEROGENEITY OF FRESHLY ISOLATED MUSCLE FIBER BUNDLES SUBJECTED TO UNIAXIAL STRETCHING

2016 ◽  
Vol 16 (06) ◽  
pp. 1650086 ◽  
Author(s):  
ATSUTAKA TAMURA ◽  
SADAYUKI HAYASHI ◽  
TAKEO MATSUMOTO
Keyword(s):  
Muscle Fiber ◽  
Fiber Bundle ◽  
Muscle Mechanics ◽  
Uniaxial Extension ◽  
Viscoelastic Behavior ◽  
Fiber Bundles ◽  
Strain Rates ◽  
Viscous Effects ◽  
Mechanical Heterogeneity ◽  
Unstable Oscillation

To investigate the effect of viscoelastic behavior on instantaneous muscle mechanics, the passive mechanical properties for the range of physiologically relevant rates should be clarified. Therefore, a series of uniaxial extension tests were conducted at various stretching rates using the muscle fiber bundles, which contained extracellular matrix (ECM) and interfibrillar microstructural components. We revealed that the tensile strength is strain rate-sensitive over the examined range, i.e., the muscle fiber bundle failed at 109[Formula: see text][Formula: see text][Formula: see text]34, 122[Formula: see text][Formula: see text][Formula: see text]44, and 179[Formula: see text][Formula: see text][Formula: see text]61[Formula: see text]kPa (mean[Formula: see text][Formula: see text][Formula: see text]SD) for strain rates of 0.02, 0.1, and 0.5[Formula: see text]s[Formula: see text], respectively. Moreover, we found that the applied stretch was not distributed uniformly even in relaxed conditions; the ratio between maximum and minimum local strains within a specimen was 2–3 on average during stretching and increased up to approximately four just before failure, indicating local mechanical heterogeneity along a fiber bundle and its exaggeration by stretching. Macroscopically, however, the tensile strain at failure was almost constant, [Formula: see text]50%. The local heterogeneity of muscle strain distribution can lead to unstable oscillation in a computational model. Thus, in addition to the intrinsic viscous effects of the muscle fiber itself, those of ECM and interfibrillar microstructural components should be considered in mathematical modeling of skeletal muscle.

Sarcomere strain and heterogeneity correlate with injury to frog skeletal muscle fiber bundles

2004 ◽  
Vol 97 (5) ◽  
pp. 1803-1813 ◽  
Author(s):  
Tina J. Patel ◽  
Ronnie Das ◽  
Jan Fridén ◽  
Gordon J. Lutz ◽  
Richard L. Lieber
Keyword(s):  
Line Width ◽  
Muscle Fiber ◽  
Muscle Activation ◽  
Sarcomere Length ◽  
Eccentric Contraction ◽  
Fiber Bundles ◽  
Lower Yield ◽  
Bathing Medium ◽  
Average Maximum ◽  
Tetanic Tension

Sarcomere length and first-order diffraction line width were measured by laser diffraction during elongation of activated frog tibialis anterior muscle fiber bundles (i.e., eccentric contraction) at nominal fiber strains of 10, 25, or 35% ( n = 18) for 10 successive contractions. Tetanic tension, measured just before each eccentric contraction, differed significantly among strain groups and changed dramatically during the 10-contraction treatment ( P < 0.01). Average maximum tetanic tension for the three groups measured before any treatment was 203.7 ± 6.8 kN/m2, but after the 10-eccentric contraction sequence decreased to 180.3 ± 3.8, 125.1 ± 7.8, and 78.3 ± 5.1 kN/m2 for the 10, 25, and 35% strain groups, respectively ( P < 0.0001). Addition of 10 mM caffeine to the bathing medium decreased the loss of tetanic tension in the 10% strain group but had only a minimal effect on either the 25 or 35% strain groups. Diffraction pattern line width, a measure of sarcomere length heterogeneity, increased significantly with muscle activation and then continued to increase with successive stretches of the activated muscle. Line width increase after each stretch was significantly correlated with the lower yield tension of the successive contractile record. These data demonstrate a direct association and, perhaps, a causal relationship between sarcomere strain and fiber bundle injury. They also demonstrate that muscle injury is accompanied by a progressive increase in sarcomere length heterogeneity, yielding lower yield tension as injury progresses.

scholarly journals Number of fiber bundles in the fetal anterior talofibular ligament

2021 ◽  
Author(s):  
Mutsuaki Edama ◽  
Tomoya Takabayashi ◽  
Hirotake Yokota ◽  
Ryo Hirabayashi ◽  
Chie Sekine ◽  
...  
Keyword(s):  
Fiber Bundle ◽  
Fiber Bundles ◽  
Anterior Talofibular Ligament ◽  
Type I ◽  
Type Ii ◽  
Crown Rump Length ◽  
Type Iii ◽  
The Difference ◽  
And Inversion

Abstract Background For the anterior talofibular ligament (ATFL), a three-fiber bundle has recently been suggested to be weaker than a single or double fiber bundle in terms of ankle plantarflexion and inversion braking function. However, the studies leading to those results all used elderly specimens. Whether the difference in fiber bundles is a congenital or an acquired morphology is important when considering methods to prevent ATFL damage. The purpose of this study was to classify the number of fiber bundles in the ATFL of fetuses. Methods This study was conducted using 30 legs from 15 Japanese fetuses (mean weight, 1764.6 ± 616.9 g; mean crown-rump length, 283.5 ± 38.7 mm; 8 males, 7 females). The ATFL was then classified by the number of fiber bundles: Type I, one fiber bundle; Type II, two fiber bundles; and Type III, three fiber bundles. Results Ligament type was Type I in 5 legs (16.7%), Type II in 21 legs (70%), and Type III in 4 legs (13.3%). Conclusions The present results suggest that the three fiber bundles of the structure of the ATFL may be an innate structure.

scholarly journals The MyoRobot technology discloses a premature biomechanical decay of skeletal muscle fiber bundles derived from R349P desminopathy mice

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Michael Haug ◽  
Charlotte Meyer ◽  
Barbara Reischl ◽  
Gerhard Prölß ◽  
Kristina Vetter ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fiber ◽  
Skeletal Muscle Fiber ◽  
Fiber Bundles

Theoretical elastic tensile behavior of muscle fiber bundles in traumatic loading events

2019 ◽  
Vol 69 ◽  
pp. 184-190 ◽  
Author(s):  
Atsutaka Tamura ◽  
Jun-ichi Hongu ◽  
Takeo Matsumoto
Keyword(s):  
Muscle Fiber ◽  
Tensile Behavior ◽  
Fiber Bundles

scholarly journals Dispersive semiflows on fiber bundles

2017 ◽  
Vol 37 (2) ◽  
pp. 85-99
Author(s):  
Josiney A. Souza ◽  
Hélio V. M. Tozatti
Keyword(s):  
Periodic Point ◽  
Fiber Bundle ◽  
Vector Bundles ◽  
Base Space ◽  
Total Space ◽  
Fiber Bundles ◽  
Almost Periodic ◽  
Special Result ◽  
Almost Periodic Point

This paper studies dispersiveness of semiflows on fiber bundles. The main result says that a right invariant semiflow on a fiber bundle is dispersive on the base space if and only if there is no almost periodic point and the semiflow is dispersive on the total space. A special result states that linear semiflows on vector bundles are not dispersive.

THE PREPARATION AND IN VITRO VIABILITY OF ISOLATED EXTERNAL INTERCOSTAL MUSCLE FIBER BUNDLES FROM SHEEP

1984 ◽  
Vol 64 (3) ◽  
pp. 785-789 ◽  
Author(s):  
M. S. WIJAYASINGHE ◽  
L. P. MILLIGAN ◽  
J. R. THOMPSON
Keyword(s):  
Muscle Fiber ◽  
Muscle Metabolism ◽  
Creatine Phosphate ◽  
Fiber Bundles ◽  
Large Animal ◽  
Intercostal Muscle ◽  
Animal Muscle ◽  
Intact Muscle

The preparation of isolated intact muscle fiber bundles from the external intercostal muscle of sheep is described. The fiber bundles maintained both ATP and creatine phosphate at levels similar to those in situ, over a 4-h incubation, and appear to be a suitable preparation for in vitro studies of large animal muscle metabolism. Key words: External intercostal muscle, isolated preparation, metabolic viability, sheep

scholarly journals A Review on Biomechanics of Anterior Cruciate Ligament and Materials for Reconstruction

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
M. Marieswaran ◽  
Ishita Jain ◽  
Bhavuk Garg ◽  
Vijay Sharma ◽  
Dinesh Kalyanasundaram
Keyword(s):  
Anterior Cruciate Ligament ◽  
Knee Joint ◽  
Cruciate Ligament ◽  
Viscoelastic Behavior ◽  
Strain Rates ◽  
Self Healing ◽  
Full Extension ◽  
Human Knee Joint ◽  
Anterior Cruciate ◽  
Synthetic Grafts

The anterior cruciate ligament is one of the six ligaments in the human knee joint that provides stability during articulations. It is relatively prone to acute and chronic injuries as compared to other ligaments. Repair and self-healing of an injured anterior cruciate ligament are time-consuming processes. For personnel resuming an active sports life, surgical repair or replacement is essential. Untreated anterior cruciate ligament tear results frequently in osteoarthritis. Therefore, understanding of the biomechanics of injury and properties of the native ligament is crucial. An abridged summary of the prominent literature with a focus on key topics on kinematics and kinetics of the knee joint and various loads acting on the anterior cruciate ligament as a function of flexion angle is presented here with an emphasis on the gaps. Briefly, we also review mechanical characterization composition and anatomy of the anterior cruciate ligament as well as graft materials used for replacement/reconstruction surgeries. The key conclusions of this review are as follows: (a) the highest shear forces on the anterior cruciate ligament occur during hyperextension/low flexion angles of the knee joint; (b) the characterization of the anterior cruciate ligament at variable strain rates is critical to model a viscoelastic behavior; however, studies on human anterior cruciate ligament on variable strain rates are yet to be reported; (c) a significant disparity on maximum stress/strain pattern of the anterior cruciate ligament was observed in the earlier works; (d) nearly all synthetic grafts have been recalled from the market; and (e) bridge-enhanced repair developed by Murray is a promising technique for anterior cruciate ligament reconstruction, currently in clinical trials. It is important to note that full extension of the knee is not feasible in the case of most animals and hence the loading pattern of human ACL is different from animal models. Many of the published reviews on the ACL focus largely on animal ACL than human ACL. Further, this review article summarizes the issues with autografts and synthetic grafts used so far. Autografts (patellar tendon and hamstring tendon) remains the gold standard as nearly all synthetic grafts introduced for clinical use have been withdrawn from the market. The mechanical strength during the ligamentization of autografts is also highlighted in this work.

Some Aspects Concerning Modeling the Eye Plant without Ocular Deviations

2014 ◽  
Vol 658 ◽  
pp. 395-400
Author(s):  
Daniela Mariana Barbu
Keyword(s):  
Eye Movement ◽  
Complex Geometry ◽  
Muscle Mechanics ◽  
Oculomotor System ◽  
Passive Component ◽  
Viscous Effects ◽  
Activation Dynamics ◽  
Force Velocity ◽  
Movement System ◽  
Developing Muscle

Oculomotor plant and saccade generator are the basics of the saccadic system. The purpose of this paper is mainly focused on mathematical models of horizontal eye movement system. In this respect, it is presented a model for the mechanics of horizontal eye movement. The oculomotor system is presented incorporates known physiological dynamics and musculotendon complex geometry. Developing muscle strength can be described by a two-component version of the model Hill and consists of a passive and active contractile component. The active component includes force-velocity and force-length characteristics of the muscle. Passive component accounts for elastic and viscous effects. Couple neuronal activation dynamics controls that is appropriate for judder from muscle mechanics.

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