scholarly journals ADVANCED OPTICAL TECHNIQUES TO EXPLORE BRAIN STRUCTURE AND FUNCTION

2013 ◽  
Vol 06 (01) ◽  
pp. 1230002 ◽  
Author(s):  
L. SILVESTRI ◽  
A. L. ALLEGRA MASCARO ◽  
J. LOTTI ◽  
L. SACCONI ◽  
F. S. PAVONE

Understanding brain structure and function, and the complex relationships between them, is one of the grand challenges of contemporary sciences. Thanks to their flexibility, optical techniques could be the key to explore this complex network. In this manuscript, we briefly review recent advancements in optical methods applied to three main issues: anatomy, plasticity and functionality. We describe novel implementations of light-sheet microscopy to resolve neuronal anatomy in whole fixed brains with cellular resolution. Moving to living samples, we show how real-time dynamics of brain rewiring can be visualized through two-photon microscopy with the spatial resolution of single synaptic contacts. The plasticity of the injured brain can also be dissected through cutting-edge optical methods that specifically ablate single neuronal processes. Finally, we report how nonlinear microscopy in combination with novel voltage sensitive dyes allow optical registrations of action potential across a population of neurons opening promising prospective in understanding brain functionality. The knowledge acquired from these complementary optical methods may provide a deeper comprehension of the brain and of its unique features.

2017 ◽  
Vol 49 (5S) ◽  
pp. 824 ◽  
Author(s):  
X. r. Tan ◽  
Ivan C. C. Low ◽  
Mary C. Stephenson ◽  
T. Kok ◽  
Heinrich W. Nolte ◽  
...  

2011 ◽  
Vol 32 (6) ◽  
pp. 814-822 ◽  
Author(s):  
Linda L. Chao ◽  
Linda Abadjian ◽  
Jennifer Hlavin ◽  
Deiter J. Meyerhoff ◽  
Michael W. Weiner

1997 ◽  
Vol 820 (1 Imaging Brain) ◽  
pp. 139-148 ◽  
Author(s):  
G. ALLAN JOHNSON ◽  
HELENE BENVENISTE ◽  
ROBERT T. ENGELHARDT ◽  
HUI QIU ◽  
LAURENCE W. HEDLUND

NeuroImage ◽  
2014 ◽  
Vol 89 ◽  
pp. 81-91 ◽  
Author(s):  
Silke Matura ◽  
David Prvulovic ◽  
Alina Jurcoane ◽  
Daniel Hartmann ◽  
Julia Miller ◽  
...  

2018 ◽  
Vol 50 (3) ◽  
pp. 2201-2210 ◽  
Author(s):  
Zhujing Shen ◽  
Peiyu Huang ◽  
Chao Wang ◽  
Wei Qian ◽  
Xiao Luo ◽  
...  

2010 ◽  
Vol 5 (4) ◽  
pp. 391-400 ◽  
Author(s):  
Denise C. Park ◽  
Chih-Mao Huang

There is clear evidence that sustained experiences may affect both brain structure and function. Thus, it is quite reasonable to posit that sustained exposure to a set of cultural experiences and behavioral practices will affect neural structure and function. The burgeoning field of cultural psychology has often demonstrated the subtle differences in the way individuals process information—differences that appear to be a product of cultural experiences. We review evidence that the collectivistic and individualistic biases of East Asian and Western cultures, respectively, affect neural structure and function. We conclude that there is limited evidence that cultural experiences affect brain structure and considerably more evidence that neural function is affected by culture, particularly activations in ventral visual cortex—areas associated with perceptual processing.


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