The Production of Radionuclides for Radiotracers in Nuclear Medicine

2009 ◽  
Vol 02 (01) ◽  
pp. 17-33 ◽  
Author(s):  
Thomas J. Ruth
Keyword(s):  
Nuclear Medicine ◽  
Biomedical Research ◽  
High Purity ◽  
Clinical Medicine ◽  
Medical Applications

Medical applications represent the vast majority of the uses for radiotracers. This review addresses how accelerators are employed for the production of high purity radionuclides that are used in basic biomedical research, as well as for clinical medicine both for diagnosing disease and for treatment.

scholarly journals Promise and Perils of Big Data and Artificial Intelligence in Clinical Medicine and Biomedical Research

2018 ◽  
Vol 123 (12) ◽  
pp. 1282-1284 ◽  
Author(s):  
Fatima Rodriguez ◽  
David Scheinker ◽  
Robert A. Harrington
Keyword(s):  
Artificial Intelligence ◽  
Big Data ◽  
Biomedical Research ◽  
Clinical Medicine

scholarly journals A Medical Pedagogy Reform by Integration of Biomedical Research into the Clinical Medicine Program

2020 ◽  
Vol 30 (4) ◽  
pp. 1569-1576
Author(s):  
Ziteng Liu ◽  
Yun He ◽  
Yi Yang ◽  
Mark Maconochie ◽  
Zhijun Luo
Keyword(s):  
Biomedical Research ◽  
Clinical Medicine

Epigenetic modification of nucleic acids: from basic studies to medical applications

2017 ◽  
Vol 46 (10) ◽  
pp. 2844-2872 ◽  
Author(s):  
Yuqi Chen ◽  
Tingting Hong ◽  
Shaoru Wang ◽  
Jing Mo ◽  
Tian Tian ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Clinical Medicine ◽  
Epigenetic Modification ◽  
Epigenetic Modifications ◽  
Detection Methods ◽  
Medical Applications ◽  
Dna And Rna ◽  
Basic Studies

This review focuses on the recent progresses in epigenetic modifications in DNA and RNA, including their epigenetic roles, detection methods and applications in clinical medicine.

The birth and future health of DOHaD

2015 ◽  
Vol 6 (5) ◽  
pp. 434-437 ◽  
Author(s):  
M. Hanson
Keyword(s):  
20Th Century ◽  
Biomedical Research ◽  
Early Life ◽  
Clinical Medicine ◽  
Communicable Disease ◽  
Future Health ◽  
Late 20Th Century ◽  
Unique Aspect ◽  
Underlying Mechanisms ◽  
Non Communicable Disease

Professor David Barker, CBE, FRS, made an enormous contribution to biomedical research, which helped to change its direction and assisted translation to clinical medicine in the area of non-communicable disease (NCD). In this paper, I briefly note some of the studies, which led to his work, and describe how the underlying mechanisms came to be investigated by fetal physiologists. This is a unique aspect of the change in scientific emphasis, from a gene-centric and adult lifestyle view of NCD to a more holistic perspective, which placed emphasis on the importance of development that took place in the late 20th century. Early this century, the DOHaD Society was formed: I discuss some aspects of the formation of the Society and note the important role it is now playing in addressing the need to find early-life interventions to reduce NCD. This forms part of the unique legacy that David Barker has left to science and medicine.

scholarly journals The use of radioactive substances in medicine — history and development prospects

2021 ◽  
Vol 67 (6) ◽  
pp. 59-67
Author(s):  
M. S. Sheremeta ◽  
A. A. Trukhin ◽  
M. O. Korchagina
Keyword(s):  
Nuclear Medicine ◽  
Gamma Ray ◽  
Clinical Medicine ◽  
Radiation Energy ◽  
Medical Specialty ◽  
80Th Anniversary ◽  
Genomic Technologies ◽  
Alpha Emission ◽  
Medicine History ◽  
Development Prospects

Nuclear medicine (NM) is a medical specialty that uses radionuclides (radioactive tracers) and ionising radiation for diagnostic and therapeutic (theranostic) purposes. Nuclear medicine arose and developed at the intersection of physics, chemistry and clinical medicine. The radiation emitted by radioisotopes can consist of gamma-, beta- and alpha emission, or it’s combination. Radioisotope of choice for medical purposes should have futher requirements: low radiotoxicity, suitable type of radiation, energy and half-life (several minutes to several hours and days), and also convenient detection of gamma ray radiation. The radionuclide is part of radiopharmaceutical (RP) and acts as its indicator. RP accumulates in morphological structures, becomes a carrier of coordinated information from patient to gamma camera or other equipment and reflects the dynamics of processes occurring in the examined organ. In 2021 NM celebrates its 80th anniversary. The trajectory of NM combines modern methods of radiotheranostics and applied genomic and post-genomic technologies.

Healthcare Digitalized

2021 ◽  
pp. 60-78
Author(s):  
Miguel H. Kottow
Keyword(s):  
Decision Making ◽  
Informed Consent ◽  
Precision Medicine ◽  
Biomedical Research ◽  
Clinical Medicine ◽  
Medical Services ◽  
Personal Care ◽  
Individual Decision ◽  
Individual Decision Making ◽  
The Relationship

Ever since medicine became a recognized profession, the relationship between patients and physicians was marked by authoritarian paternalism. With the advent of bioethics in the 1970s, patients' right to participate in decision making led to proclaim autonomy as the primary principle in clinical medicine and biomedical research, practically exercised as informed consent; yet, the issue remains contended and poorly regulated. Healthcare digitalization disassembles persons into clouds of data. Individual decision making is interfered with and replaced by dominant algorithms, supposedly delivering a P4 composite of precision medicine: personalized, preventive, predictive, participatory. Biomedicine develops into medicalization, marketization contractual client/provider relationship, and neglect of personal care for the ill and frail. These trends become dominant in digitalized healthcare as personal healthcare relationships, and ethically unsatisfactory medical services replace the psychosocial, existential elements of health/disease.

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