Considering the fact that the forms of asphalt pavement potholes, subsidence and cement pavement potholes (collectively defined as pavement pothole-subsidence) are similar and they can influence traffic flow significantly, we put forward to use indexes such as Tangential Diameter Length, Normal Diameter Length, Depth, Lateral distance, etc to describe the characteristics of pothole-subsidence, and we also adopt AutoScope-2004 video detection system aided by artificial judging to investigate in the surveyed road section. According to different wheel paths, driving modes was classified into three types, influences of various pothole-subsidence on driving mode and speed was analyzed. We came up with conclusions as follows: one is that pothole-subsidence significantly influenced the variation of vehicle trajectory, 78.5% vehicles altered their driving direction, and the average rate of speed descent is over 20%.