Early Alert Systems During a Pandemic: A Simulation Study on the Impact of Concept Drift

2021 ◽  
Author(s):  
Yang Xu ◽  
Kevin Wilson
Keyword(s):  
Simulation Study ◽  
Concept Drift ◽  
Early Alert Systems ◽  
The Impact ◽  
Early Alert

scholarly journals The impact of excluding or including Death Certificate Initiated (DCI) cases on estimated cancer survival: A simulation study

2021 ◽  
Vol 71 ◽  
pp. 101881
Author(s):  
Therese M.-L. Andersson ◽  
Tor Åge Myklebust ◽  
Mark J. Rutherford ◽  
Bjørn Møller ◽  
Isabelle Soerjomataram ◽  
...  
Keyword(s):  
Simulation Study ◽  
Cancer Survival ◽  
Death Certificate ◽  
The Impact

scholarly journals When does the use of individual patient data in network meta-analysis make a difference? A simulation study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Steve Kanters ◽  
Mohammad Ehsanul Karim ◽  
Kristian Thorlund ◽  
Aslam Anis ◽  
Nick Bansback
Keyword(s):  
Simulation Study ◽  
Treatment Effect ◽  
Mean Squared Error ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Model Performance ◽  
Patient Data ◽  
Meta Regression ◽  
Treatment Comparisons ◽  
The Impact

Abstract Background The use of individual patient data (IPD) in network meta-analyses (NMA) is rapidly growing. This study aimed to determine, through simulations, the impact of select factors on the validity and precision of NMA estimates when combining IPD and aggregate data (AgD) relative to using AgD only. Methods Three analysis strategies were compared via simulations: 1) AgD NMA without adjustments (AgD-NMA); 2) AgD NMA with meta-regression (AgD-NMA-MR); and 3) IPD-AgD NMA with meta-regression (IPD-NMA). We compared 108 parameter permutations: number of network nodes (3, 5 or 10); proportion of treatment comparisons informed by IPD (low, medium or high); equal size trials (2-armed with 200 patients per arm) or larger IPD trials (500 patients per arm); sparse or well-populated networks; and type of effect-modification (none, constant across treatment comparisons, or exchangeable). Data were generated over 200 simulations for each combination of parameters, each using linear regression with Normal distributions. To assess model performance and estimate validity, the mean squared error (MSE) and bias of treatment-effect and covariate estimates were collected. Standard errors (SE) and percentiles were used to compare estimate precision. Results Overall, IPD-NMA performed best in terms of validity and precision. The median MSE was lower in the IPD-NMA in 88 of 108 scenarios (similar results otherwise). On average, the IPD-NMA median MSE was 0.54 times the median using AgD-NMA-MR. Similarly, the SEs of the IPD-NMA treatment-effect estimates were 1/5 the size of AgD-NMA-MR SEs. The magnitude of superior validity and precision of using IPD-NMA varied across scenarios and was associated with the amount of IPD. Using IPD in small or sparse networks consistently led to improved validity and precision; however, in large/dense networks IPD tended to have negligible impact if too few IPD were included. Similar results also apply to the meta-regression coefficient estimates. Conclusions Our simulation study suggests that the use of IPD in NMA will considerably improve the validity and precision of estimates of treatment effect and regression coefficients in the most NMA IPD data-scenarios. However, IPD may not add meaningful validity and precision to NMAs of large and dense treatment networks when negligible IPD are used.

Molecular Dynamics Study on the Impact of the Cutting Depth to the Titanium Nanometric Cutting

2014 ◽  
Vol 536-537 ◽  
pp. 1431-1434 ◽  
Author(s):  
Ying Zhu ◽  
Yin Cheng Zhang ◽  
Shun He Qi ◽  
Zhi Xiang
Keyword(s):  
Molecular Dynamics ◽  
Potential Energy ◽  
Cutting Force ◽  
Simulation Study ◽  
Cutting Process ◽  
Work Piece ◽  
Cutting Depth ◽  
Nanometric Cutting ◽  
The Impact

Based on the molecular dynamics (MD) theory, in this article, we made a simulation study on titanium nanometric cutting process at different cutting depths, and analyzed the changes of the cutting depth to the effects on the work piece morphology, system potential energy, cutting force and work piece temperature in this titanium nanometric cutting process. The results show that with the increase of the cutting depth, system potential energy, cutting force and work piece temperature will increase correspondingly while the surface quality of machined work piece will decrease.

scholarly journals Quantifying the Impact of Natural Immunity on Rotavirus Vaccine Efficacy Estimates: A Clinical Trial in Dhaka, Bangladesh (PROVIDE) and a Simulation Study

2018 ◽  
Vol 217 (6) ◽  
pp. 861-868 ◽  
Author(s):  
Elizabeth T Rogawski ◽  
James A Platts-Mills ◽  
E Ross Colgate ◽  
Rashidul Haque ◽  
K Zaman ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Simulation Study ◽  
Vaccine Efficacy ◽  
Natural Immunity ◽  
Rotavirus Vaccine ◽  
The Impact

The impact of (S,s) policy on supply network performance: a simulation study

2012 ◽  
Vol 4 (2) ◽  
pp. 164 ◽  
Author(s):  
Eleonora Bottani ◽  
Gino Ferretti ◽  
Roberto Montanari ◽  
Giuseppe Vignali
Keyword(s):  
Simulation Study ◽  
Network Performance ◽  
Supply Network ◽  
The Impact
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