The Organizing Principles of Eukaryotic Ribosome Recruitment

2019 ◽  
Vol 88 (1) ◽  
pp. 307-335 ◽  
Author(s):  
Jerry Pelletier ◽  
Nahum Sonenberg
Keyword(s):  
Protein Synthesis ◽  
Initiation Codon ◽  
Messenger Rnas ◽  
Eukaryotic Ribosome ◽  
Initiation Factors ◽  
Organizing Principles

The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is positioned at an appropriate initiation codon and primed to synthesize the encoded polypeptide product. In most circumstances, this step commits the ribosome to translate the mRNA. We summarize the knowledge regarding the initiation factors implicated in this activity as well as review different mechanisms by which this process is conducted.

scholarly journals Characterization of the ATP-dependent binding of wheat germ protein synthesis initiation factors eIF-(iso)4F and eIF-4A to mRNA.

1993 ◽  
Vol 268 (25) ◽  
pp. 18599-18603
Author(s):  
M.L. Balasta ◽  
S.E. Carberry ◽  
D.E. Friedland ◽  
R.A. Perez ◽  
D.J. Goss
Keyword(s):  
Protein Synthesis ◽  
Wheat Germ ◽  
Initiation Factors ◽  
Protein Synthesis Initiation

Subcellular localization of mRNA and factors involved in translation initiation

2008 ◽  
Vol 36 (4) ◽  
pp. 648-652 ◽  
Author(s):  
Nathaniel P. Hoyle ◽  
Mark P. Ashe
Keyword(s):  
Protein Synthesis ◽  
Subcellular Localization ◽  
Translation Initiation ◽  
Potential Functions ◽  
Present Review ◽  
Cellular Activity ◽  
Initiation Factors ◽  
Translation Initiation Factors

Both the process and synthesis of factors required for protein synthesis (or translation) account for a large proportion of cellular activity. In eukaryotes, the most complex and highly regulated phase of protein synthesis is that of initiation. For instance, across eukaryotes, at least 12 factors containing 22 or more proteins are involved, and there are several regulated steps. Recently, the localization of mRNA and factors involved in translation has received increased attention. The present review provides a general background to the subcellular localization of mRNA and translation initiation factors, and focuses on the potential functions of localized translation initiation factors. That is, as genuine sites for translation initiation, as repositories for factors and mRNA, and as sites of regulation.

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